Myosin-heavy-chain kinase

myosin heavy chain kinase
Identifiers
EC number	2.7.11.7
CAS number	64763-54-8
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles

In enzymology, a myosin-heavy-chain kinase (EC 2.7.11.7) is an enzyme that catalyzes the chemical reaction

ATP + [myosin heavy-chain] $\rightleftharpoons$ ADP + [myosin heavy-chain] phosphate

Thus, the two substrates of this enzyme are ATP and myosin heavy-chain, whereas its two products are ADP and myosin heavy-chain phosphate.

This enzyme belongs to the family of transferases, specifically those transferring a phosphate group to the sidechain oxygen atom of serine or threonine residues in proteins (protein-serine/threonine kinases). The systematic name of this enzyme class is ATP:[myosin heavy-chain] O-phosphotransferase. Other names in common use include

• ATP:myosin-heavy-chain O-phosphotransferase
• calmodulin-dependent myosin heavy chain kinase
• MHCK
• MIHC kinase
• myosin heavy chain kinase
• myosin I heavy-chain kinase
• myosin II heavy-chain kinase
• [myosin-heavy-chain] kinase
• myosin heavy chain kinase A
• STK6.

References

• Cote GP, Bukiejko U (1987). "Purification and characterization of a myosin heavy chain kinase from Dictyostelium discoideum". J. Biol. Chem. 262 (3): 1065–72. PMID 3027076. 
• Hammer JA 3rd Albanesi JP, Korn ED (1983). "Purification and characterization of a myosin I heavy chain kinase from Acanthamoeba castellanii". J. Biol. Chem. 258 (16): 10168–75. PMID 6309772. 
• Rieker JP, Swanljung-Collins H, Collins JH (1987). "Purification and characterization of a calmodulin-dependent myosin heavy chain kinase from intestinal brush border". J. Biol. Chem. 262 (31): 15262–8. PMID 2822719. 
• Ravid S, Spudich JA (1989). "Myosin heavy chain kinase from developed Dictyostelium cells Purification and characterization". J. Biol. Chem. 264 (25): 15144–50. PMID 2549052. 
• Brzeska H, Lynch TJ, Martin B, Corigliano-Murphy A, Korn ED (1990). "Substrate specificity of Acanthamoeba myosin I heavy chain kinase as determined with synthetic peptides". J. Biol. Chem. 265 (27): 16138–44. PMID 2168881. 
• Ravid S, Spudich JA (1992). "Membrane-bound Dictyostelium myosin heavy chain kinase: a developmentally regulated substrate-specific member of the protein kinase C family". Proc. Natl. Acad. Sci. U. S. A. 89 (13): 5877–81. doi:10.1073/pnas.89.13.5877. PMC 49400. PMID 1321427. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=49400. 
• Futey LM, Medley QG, Cote GP, Egelhoff TT (1995). "Structural analysis of myosin heavy chain kinase A from Dictyostelium. Evidence for a highly divergent protein kinase domain, an amino-terminal coiled-coil domain, and a domain homologous to the beta-subunit of heterotrimeric G proteins". J. Biol. Chem. 270 (2): 523–9. doi:10.1074/jbc.270.2.523. PMID 7822274. 
• Korn ED, Brzeska H (1998). "Effect of mutating the regulatory phosphoserine and conserved threonine on the activity of the expressed catalytic domain of Acanthamoeba myosin I heavy chain kinase". Proc. Natl. Acad. Sci. U. S. A. 95 (8): 4146–51. doi:10.1073/pnas.95.8.4146. PMC 22456. PMID 9539704. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=22456. 
• Egelhoff TT, Croft D, Steimle PA (2005). "Actin activation of myosin heavy chain kinase A in Dictyostelium: a biochemical mechanism for the spatial regulation of myosin II filament disassembly". J. Biol. Chem. 280 (4): 2879–87. doi:10.1074/jbc.M410803200. PMID 15545285. 

This enzyme-related article is a stub. You can help Wikipedia by expanding it.v · Categories: Enzyme stubs EC 2.7.11 Enzymes of unknown structure Wikimedia Foundation. 2010. Игры ⚽ Нужна курсовая? Cyrus Shaw Freedom (Paul McCartney song) Look at other dictionaries: Myosin light-chain kinase — myosin light polypeptide kinase, smooth muscle Identifiers Symbol MYLK Entrez 4638 HUGO …   Wikipedia Myosin binding protein C, cardiac — PDB rendering based on 1gxe …   Wikipedia myosin light chains — Small subunit proteins (17 22 kD) of myosin II, all with sequence homology to calmodulin, but not all with calcium binding activity: two pairs of different light chains are found per myosin. Several types are known: regulatory light chains (LC 2 …   Dictionary of molecular biology Ca2+/calmodulin-dependent protein kinase — Calcium/calmodulin dependent protein kinase II association domain crystal structure of calcium/calmodulin dependent protein kinase Identifiers Symbol CaMKII AD …   Wikipedia Protein kinase A — In cell biology, Protein kinase A (PKA) refers to a family of enzymes whose activity is dependent on cellular levels of cyclic AMP (cAMP). PKA is also known as cAMP dependent protein kinase (EC 2.7.11.11). Protein kinase A has several functions… …   Wikipedia P70S6 kinase — or p70S6K is a serine/threonine kinase that acts downstream of PIP3 and phosphoinositide dependent kinase 1 in the PI3 kinase pathway.[1] As the name suggests, its target substrate is the S6 ribosomal protein.[2] Phosphorylation of S6 induces… …   Wikipedia Cyclin-dependent kinase — Schematic of the cell cycle. outer ring: I=Interphase, M=Mitosis; inner ring: M=Mitosis; G1=Gap phase 1; S=Synthesis; G2=Gap phase 2. The duration of mitosis in relation to the other phases has been exaggerated in this diagram Cyclin dependent… …   Wikipedia Mitogen-activated protein kinase — Identifiers EC number 2.7.11.24 CAS number 142243 02 5 …   Wikipedia MAP kinase kinase kinase — (or MAP3K or MEKK) is a serine/threonine specific protein kinase which acts upon MAP kinase kinase. In humans there are at least 19 genes: MAP3K1 (aka MEKK1) MAP3K2 MAP3K3 (aka MEKK3) MAP3K4 MAP3K5 (aka ASK1) MAP3K6 (aka ASK2) MAP3K7 (aka MEKK7)… …   Wikipedia Mitogen-activated protein kinase 9 — Rendering based on PDB 3E7O …   Wikipedia 18+ © Academic, 2000-2024 Contact us: Technical Support, Advertising Dictionaries export, created on PHP, Joomla, Drupal, WordPress, MODx. Mark and share Search through all dictionaries Translate… Search Internet Share the article and excerpts Direct link … Do a right-click on the link above and select “Copy Link”