Receptor protein serine/threonine kinase

Receptor protein serine/threonine kinase

In enzymology, a receptor protein serine/threonine kinase (EC number|2.7.11.30) is an enzyme that catalyzes the chemical reaction

:ATP + [receptor-protein] ightleftharpoons ADP + [receptor-protein] phosphate

Thus, the two substrates of this enzyme are ATP and [receptor-protein] , whereas its two products are ADP and [receptor-protein] phosphate.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups protein-serine/threonine kinases. The systematic name of this enzyme class is ATP: [receptor-protein] phosphotransferase. Other names in common use include activin receptor kinase, receptor type I serine/threonine protein kinase, receptor type II serine/threonine protein kinase, STK13, TGF-beta kinase, and receptor serine/threonine protein kinase. This enzyme participates in 7 metabolic pathways: mapk signaling pathway, cytokine-cytokine receptor interaction, tgf-beta signaling pathway, adherens junction, colorectal cancer, pancreatic cancer, and chronic myeloid leukemia.

tructural studies

As of late 2007, 5 structures have been solved for this class of enzymes, with PDB accession codes PDB link|2GOO, PDB link|2H62, PDB link|2H64, PDB link|2HLQ, and PDB link|2HLR.

References

*
*
*

External links


Wikimedia Foundation. 2010.

Игры ⚽ Поможем решить контрольную работу

Look at other dictionaries:

  • receptor protein serine/threonine kinase — re·cep·tor pro·tein ser·ine/thre·o·nine ki·nase (re sepґtər proґtēn sērґēn threґo nēn kiґnās) [EC 2.7.11.30] a group comprising those protein serine/threonine kinases with a transmembrane domain. Each occurs as a… …   Medical dictionary

  • protein-serine/threonine kinase — pro·tein ser·ine/thre·o·nine ki·nase (proґtēn sērґēn threґo nēn kiґnās) [EC 2.7.11] any of the protein kinases that phosphorylate specific serine or threonine residues in proteins. The group is divided into receptor… …   Medical dictionary

  • non-specific serine/threonine protein kinase — non spe·cif·ic ser·ine/thre·o·nine pro·tein ki·nase (non″spə sifґik sērґēn threґo nēn proґtēn kiґnās) [EC 2.7.11.1] a group comprising those protein serine/threonine kinases that do not have a transmembrane… …   Medical dictionary

  • Non-specific serine/threonine protein kinase — In enzymology, a non specific serine/threonine protein kinase (EC number|2.7.11.1) is an enzyme that catalyzes the chemical reaction:ATP + a protein ightleftharpoons ADP + a phosphoproteinThus, the two substrates of this enzyme are ATP and… …   Wikipedia

  • Protein kinase A — In cell biology, Protein kinase A (PKA) refers to a family of enzymes whose activity is dependent on cellular levels of cyclic AMP (cAMP). PKA is also known as cAMP dependent protein kinase (EC 2.7.11.11). Protein kinase A has several functions… …   Wikipedia

  • Mitogen-activated protein kinase — Identifiers EC number 2.7.11.24 CAS number 142243 02 5 …   Wikipedia

  • Dual-specificity kinase — Identifiers EC number 2.7.12.1 CAS number 134549 83 0 …   Wikipedia

  • Phosphoinositide-dependent kinase-1 — 3 phosphoinositide dependent protein kinase 1 PDB rendering based on 1h1w …   Wikipedia

  • Ca2+/calmodulin-dependent protein kinase — Calcium/calmodulin dependent protein kinase II association domain crystal structure of calcium/calmodulin dependent protein kinase Identifiers Symbol CaMKII AD …   Wikipedia

  • Mitogen-activated protein kinase 9 — Rendering based on PDB 3E7O …   Wikipedia

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”