RhoGEF domain

RhoGEF domain
Structure of the Dbl and pleckstrin homology domains from the human Son of sevenless protein.[1]
Identifiers
Symbol	RhoGEF
Pfam	PF00621
InterPro	IPR000219
SMART	RhoGEF
SCOP	1dbh
OPM protein	1xd4
Available protein structures: Pfam structures PDB RCSB PDB; PDBe PDBsum structure summary

RhoGEF domain is a structural domain of guanine nucleotide exchange factors for Rho/Rac/Cdc42-like GTPases. It is also called "Dbl-homologous" (DH) domain.

Subfamilies

• Guanine-nucleotide dissociation stimulator, CDC24 IPR001331

Human proteins containing this domain

ABR; AKAP13; ARHGEF1; ARHGEF10; ARHGEF10L; ARHGEF11; ARHGEF12; ARHGEF15; ARHGEF16; ARHGEF17; ARHGEF18; ARHGEF19; ARHGEF2; ARHGEF3; ARHGEF4; ARHGEF5; ARHGEF6; ARHGEF7; ARHGEF9; ASEF2; BCR; C9orf100; DEPDC2; DNMBP; ECT2; FARP1; FARP2; FGD1; FGD2; FGD3; FGD4; FGD5; FGD6; GEFT; ITSN1; ITSN2; KALRN; LFDH; MCF2; MCF2L; MCF2L2; NET1; NGEF; OBSCN; PLEKHG1; PLEKHG2; PLEKHG3; PLEKHG4; PLEKHG5; PLEKHG6; PREX1; RASGRF1; SGEF; SOS1; SOS2; SPATA13; TIAM1; TIAM2; TRIO; VAV1; VAV2; VAV3;

Notes

1. ^ Soisson SM, Nimnual AS, Uy M, Bar-Sagi D, Kuriyan J (October 1998). "Crystal structure of the Dbl and pleckstrin homology domains from the human Son of sevenless protein". Cell 95 (2): 259–68. doi:10.1016/S0092-8674(00)81756-0. PMID 9790532. 

References

• The Dbl family of oncogenes. Cerione RA, Zheng Y; Curr Opin Cell Biol 1996;8:216-222. PubMed
• Catalysis of guanine nucleotide exchange on the CDC42Hs protein by the dbl oncogene product. Hart MJ, Eva A, Evans T, Aaronson SA, Cerione RA; Nature 1991;354:311-314. PubMed
• The human active breakpoint cluster region-related gene encodes a brain protein with homology to guanine nucleotide exchange proteins and GTPase-activating proteins. Tan EC, Leung T, Manser E, Lim L; J Biol Chem 1993;268:27291-27298. PubMed
• Crystal structure of the Dbl and pleckstrin homology domains from the human Son of sevenless protein. Soisson SM, Nimnual AS, Uy M, Bar-Sagi D, Kuriyan J; Cell 1998;95:259-268. PubMed

This membrane protein-related article is a stub. You can help Wikipedia by expanding it.v · Categories: Protein domains Peripheral membrane proteins Membrane protein stubs Wikimedia Foundation. 2010. Игры ⚽ Нужен реферат? Arceuthobium campylopodum Idiots Deluxe Look at other dictionaries: FYVE, RhoGEF and PH domain containing — (FGD) is a gene family consisting of: * * * *Type 1 is associated with Aarskog Scott syndrome.ee also* Guanine nucleotide exchange factorExternal links* * …   Wikipedia OBSCN — Obscurin, cytoskeletal calmodulin and titin interacting RhoGEF PDB rendering based on 1v1c …   Wikipedia PLEKHG4 — Pleckstrin homology domain containing, family G (with RhoGef domain) member 4, also known as PLEKHG4, is a human gene.cite web | title = Entrez Gene: PLEKHG4 pleckstrin homology domain containing, family G (with RhoGef domain) member 4| url =… …   Wikipedia ALS2 — Amyotrophic lateral sclerosis 2 (juvenile), also known as ALS2, is a human gene.cite web | title = Entrez Gene: ALS2 amyotrophic lateral sclerosis 2 (juvenile)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView… …   Wikipedia ARHGEF1 — Rho guanine nucleotide exchange factor (GEF) 1, also known as ARHGEF1, is a human gene.cite web | title = Entrez Gene: ARHGEF1 Rho guanine nucleotide exchange factor (GEF) 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene… …   Wikipedia FARP1 — FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte derived), also known as FARP1, is a human gene.cite web | title = Entrez Gene: FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte derived)| url =… …   Wikipedia ARHGEF11 — Rho guanine nucleotide exchange factor (GEF) 11, also known as ARHGEF11, is a human gene.cite web | title = Entrez Gene: ARHGEF11 Rho guanine nucleotide exchange factor (GEF) 11| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene… …   Wikipedia FGD1 (gene) — FYVE, RhoGEF and PH domain containing 1 (faciogenital dysplasia), also known as FGD1, is a human gene.cite web | title = Entrez Gene: FGD1 FYVE, RhoGEF and PH domain containing 1 (faciogenital dysplasia)| url =… …   Wikipedia ARHGEF12 — Rho guanine nucleotide exchange factor (GEF) 12, also known as ARHGEF12, is a human gene.cite web | title = Entrez Gene: ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene… …   Wikipedia FARP2 — FERM, RhoGEF and pleckstrin domain protein 2, also known as FARP2, is a human gene.cite web | title = Entrez Gene: FARP2 FERM, RhoGEF and pleckstrin domain protein 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView… …   Wikipedia 18+ © Academic, 2000-2024 Contact us: Technical Support, Advertising Dictionaries export, created on PHP, Joomla, Drupal, WordPress, MODx. Mark and share Search through all dictionaries Translate… Search Internet Share the article and excerpts Direct link … Do a right-click on the link above and select “Copy Link”