Transmembrane domain of ABC transporters

Transmembrane domain of ABC transporters

Pfam_box
Symbol = ABC_membrane
Name = ABC transporter transmembrane region


width =
caption =
Pfam= PF00664
InterPro= IPR001140
SMART=
PROSITE = PDOC00364
SCOP = 1pf4
TCDB = 3.A.1
OPM family= 18
OPM protein= 1pf4
PDB=

ABC transporter transmembrane domain is main transmembrane structural unit of ATP-binding cassette transporter which consist of six transmembrane domaines. Many members of the ABC transporter family (Pfam|PF00005) have two such regions.cite journal |author=Kerr ID |title=Structure and association of ATP-binding cassette transporter nucleotide-binding domains |journal=Biochim. Biophys. Acta |volume=1561 |issue=1 |pages=- |year=2002 |pmid=11988180] .cite journal |author=Hunt JF, Yuan YR, Martsinkevich O, Millen L, Thomas PJ, Karpowich N, Dai PL, MacVey K |title=Crystal structures of the MJ1267 ATP binding cassette reveal an induced-fit effect at the ATPase active site of an ABC transporter |journal=Structure |volume=9 |issue=7 |pages=- |year=2001 |pmid=11470432] cite journal |author=Hunt JF, Yuan YR, Blecker S, Martsinkevich O, Millen L, Thomas PJ |title=The crystal structure of the MJ0796ATP-binding cassette. Implications for the structural consequences of ATP hydrolysis in the active site of an ABC transporter |journal=J. Biol. Chem. |volume=276 |issue=34 |pages=- |year=2001 |pmid=11402022] cite journal |author=Kim SH, Hung LW, Wang IX, Nikaido K, Liu PQ, Ames GF |title=Crystal structure of the ATP-binding subunit of an ABC transporter |journal=Nature |volume=396 |issue=6712 |pages=703–707 |year=1998 |pmid=9872322 |doi=10.1038/25393] cite journal |author=Welte W, Breed J, Boos W, Diederichs K, Vonrhein C, Muller C, Diez J, Greller G, Schnell C |title=Crystal structure of MalK, the ATPase subunit of the trehalose/maltose ABC transporter of the archaeon Thermococcus litoralis |journal=EMBO J. |volume=19 |issue=22 |pages=- |year=2000 |pmid=11080142 |doi=10.1093/emboj/19.22.5951] cite journal |author=Wiley DC, Gaudet R |title=Structure of the ABC ATPase domain of human TAP1, the transporter associated with antigen processing|journal=EMBO J. |volume=20 |issue=17 |pages=- |year=2001 |pmid=11532960 |doi=10.1093/emboj/20.17.4964]

Human proteins containing this domain

ABCB1; ABCB10; ABCB11; ABCB4; ABCB5; ABCB6; ABCB7; ABCB8;
ABCB9; ABCC1; ABCC10; ABCC11; ABCC12; ABCC13; ABCC2; ABCC3;
ABCC4; ABCC5; ABCC6; ABCC8; ABCC9; CFTR; LOC402251; MRP3;
TAP1; TAP2; TAPL; ara;

References

External links

* [http://www.expasy.org/cgi-bin/nicedoc.pl?PDOC00364 ABC transporter integral membrane type-1 domain] in PROSITE


Wikimedia Foundation. 2010.

Игры ⚽ Поможем сделать НИР

Look at other dictionaries:

  • ATP-binding domain of ABC transporters — Pfam box Symbol = ABC tran Name = width = caption =Multidrug ABC transporter SAV1866, closed state Pfam= PF00005 InterPro= IPR003439 SMART= PROSITE = PDOC00185 SCOP = 1b0u TCDB = 3.A.1 OPM family= 17 OPM protein=2hyd PDB=PDB3|1vplA:29 210… …   Wikipedia

  • Transmembrane protein — A transmembrane protein is a protein that spans the entire biological membrane. Transmembrane proteins aggregate and precipitate in water. They require detergents or nonpolar solvents for extraction, although some of them (beta barrels) can be… …   Wikipedia

  • Cystic fibrosis transmembrane conductance regulator — (ATP binding cassette sub family C, member 7) NBD1 of human CFTR complexed with ATP. PDB rendering based on 1xmi …   Wikipedia

  • ATP-binding cassette transporter — ATP binding cassette transporters (ABC transporter) are members of a superfamily that is one of the largest, and most ancient families with representatives in all extant phyla from prokaryotes to humans. Ref|Jones2004. These are transmembrane… …   Wikipedia

  • P-glycoprotein — ATP binding cassette, sub family B (MDR/TAP), member 1 Crystallographic structure of the mouse MDR3 protein. The approximate positioning of the protein in the cell membrane is indicated by the blue (extracellular face) and red (cytoplasmic face)… …   Wikipedia

  • Multidrug resistance-associated protein 2 — ATP binding cassette, sub family C (CFTR/MRP), member 2 Identifiers Symbols ABCC2; ABC30; CMOAT; DJS; KIAA1010; MRP2; cMRP External IDs …   Wikipedia

  • Sterolin — protein Name = ATP binding cassette, sub family G (WHITE), member 5 (sterolin 1) caption = width = HGNCid = 13886 Symbol = ABCG5 AltSymbols = EntrezGene = 64240 OMIM = 605459 RefSeq = NM 022436 UniProt = Q9H222 PDB = ECnumber = Chromosome = 2 Arm …   Wikipedia

  • ABCG2 — ATP binding cassette, sub family G (WHITE), member 2 Identifiers Symbols ABCG2; ABC15; ABCP; BCRP; BCRP1; BMDP; CD338; CDw338; EST157481; MGC102821; MRX; MXR; MXR1 External IDs …   Wikipedia

  • Cystic fibrosis — Classification and external resources A breathing treatment for cystic fibrosis, using a mask nebuliser and a ThAIRapy Vest ICD 10 E …   Wikipedia

  • ATP-binding cassette family — The ATP binding cassette (ABC) family is a group of proteins which bind and hydrolyse ATP in order to transport substances across cellular membranes. They are prevalent in bacteria but are also in humans, and responsible for a diverse range of… …   Wikipedia

Share the article and excerpts

Direct link
… Do a right-click on the link above
and select “Copy Link”