Fucosyltransferase 3

Fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group), also known as FUT3, is a human gene.cite web | title = Entrez Gene: FUT3 fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2525| accessdate = ]

PBB_Summary
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summary_text = The Lewis histo-blood group system comprises a set of fucosylated glycosphingolipids that are synthesized by exocrine epithelial cells and circulate in body fluids. The glycosphingolipids function in embryogenesis, tissue differentiation, tumor metastasis, inflammation, and bacterial adhesion. They are secondarily absorbed to red blood cells giving rise to their Lewis phenotype. This gene is a member of the fucosyltransferase family, which catalyzes the addition of fucose to precursor polysaccharides in the last step of Lewis antigen biosynthesis. It encodes an enzyme with alpha(1,3)-fucosyltransferase and alpha(1,4)-fucosyltransferase activities. Mutations in this gene are responsible for the majority of Lewis antigen-negative phenotypes. Multiple alternatively spliced variants, encoding the same protein, have been found for this gene.cite web | title = Entrez Gene: FUT3 fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2525| accessdate = ]

ee also

* Cluster of differentiation

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Weston BW, Nair RP, Larsen RD, Lowe JB |title=Isolation of a novel human alpha (1,3)fucosyltransferase gene and molecular comparison to the human Lewis blood group alpha (1,3/1,4)fucosyltransferase gene. Syntenic, homologous, nonallelic genes encoding enzymes with distinct acceptor substrate specificities. |journal=J. Biol. Chem. |volume=267 |issue= 6 |pages= 4152–60 |year= 1992 |pmid= 1740457 |doi=
*cite journal | author=Kukowska-Latallo JF, Larsen RD, Nair RP, Lowe JB |title=A cloned human cDNA determines expression of a mouse stage-specific embryonic antigen and the Lewis blood group alpha(1,3/1,4)fucosyltransferase. |journal=Genes Dev. |volume=4 |issue= 8 |pages= 1288–303 |year= 1990 |pmid= 1977660 |doi=
*cite journal | author=Cameron HS, Szczepaniak D, Weston BW |title=Expression of human chromosome 19p alpha(1,3)-fucosyltransferase genes in normal tissues. Alternative splicing, polyadenylation, and isoforms. |journal=J. Biol. Chem. |volume=270 |issue= 34 |pages= 20112–22 |year= 1995 |pmid= 7650030 |doi=
*cite journal | author=Reguigne-Arnould I, Couillin P, Mollicone R, "et al." |title=Relative positions of two clusters of human alpha-L-fucosyltransferases in 19q (FUT1-FUT2) and 19p (FUT6-FUT3-FUT5) within the microsatellite genetic map of chromosome 19. |journal=Cytogenet. Cell Genet. |volume=71 |issue= 2 |pages= 158–62 |year= 1995 |pmid= 7656588 |doi=
*cite journal | author=Nishihara S, Nakazato M, Kudo T, "et al." |title=Human alpha-1,3 fucosyltransferase (FucT-VI) gene is located at only 13 kb 3' to the Lewis type fucosyltransferase (FucT-III) gene on chromosome 19. |journal=Biochem. Biophys. Res. Commun. |volume=190 |issue= 1 |pages= 42–6 |year= 1993 |pmid= 7916594 |doi= 10.1006/bbrc.1993.1008
*cite journal | author=Nishihara S, Narimatsu H, Iwasaki H, "et al." |title=Molecular genetic analysis of the human Lewis histo-blood group system. |journal=J. Biol. Chem. |volume=269 |issue= 46 |pages= 29271–8 |year= 1994 |pmid= 7961897 |doi=
*cite journal | author=Mollicone R, Reguigne I, Kelly RJ, "et al." |title=Molecular basis for Lewis alpha(1,3/1,4)-fucosyltransferase gene deficiency (FUT3) found in Lewis-negative Indonesian pedigrees. |journal=J. Biol. Chem. |volume=269 |issue= 33 |pages= 20987–94 |year= 1994 |pmid= 8063716 |doi=
*cite journal | author=Koda Y, Kimura H, Mekada E |title=Analysis of Lewis fucosyltransferase genes from the human gastric mucosa of Lewis-positive and -negative individuals. |journal=Blood |volume=82 |issue= 9 |pages= 2915–9 |year= 1993 |pmid= 8219240 |doi=
*cite journal | author=Elmgren A, Rydberg L, Larson G |title=Genotypic heterogeneity among Lewis negative individuals. |journal=Biochem. Biophys. Res. Commun. |volume=196 |issue= 2 |pages= 515–20 |year= 1993 |pmid= 8240322 |doi= 10.1006/bbrc.1993.2280
*cite journal | author=Nishihara S, Yazawa S, Iwasaki H, "et al." |title=Alpha (1,3/1,4)fucosyltransferase (FucT-III) gene is inactivated by a single amino acid substitution in Lewis histo-blood type negative individuals. |journal=Biochem. Biophys. Res. Commun. |volume=196 |issue= 2 |pages= 624–31 |year= 1993 |pmid= 8240337 |doi= 10.1006/bbrc.1993.2295
*cite journal | author=Elmgren A, Börjeson C, Svensson L, "et al." |title=DNA sequencing and screening for point mutations in the human Lewis (FUT3) gene enables molecular genotyping of the human Lewis blood group system. |journal=Vox Sang. |volume=70 |issue= 2 |pages= 97–103 |year= 1996 |pmid= 8801770 |doi=
*cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=
*cite journal | author=Orntoft TF, Vestergaard EM, Holmes E, "et al." |title=Influence of Lewis alpha1-3/4-L-fucosyltransferase (FUT3) gene mutations on enzyme activity, erythrocyte phenotyping, and circulating tumor marker sialyl-Lewis a levels. |journal=J. Biol. Chem. |volume=271 |issue= 50 |pages= 32260–8 |year= 1997 |pmid= 8943285 |doi=
*cite journal | author=Elmgren A, Mollicone R, Costache M, "et al." |title=Significance of individual point mutations, T202C and C314T, in the human Lewis (FUT3) gene for expression of Lewis antigens by the human alpha(1,3/1,4)-fucosyltransferase, Fuc-TIII. |journal=J. Biol. Chem. |volume=272 |issue= 35 |pages= 21994–8 |year= 1997 |pmid= 9268337 |doi=
*cite journal | author=Pang H, Liu Y, Koda Y, "et al." |title=Five novel missense mutations of the Lewis gene (FUT3) in African (Xhosa) and Caucasian populations in South Africa. |journal=Hum. Genet. |volume=102 |issue= 6 |pages= 675–80 |year= 1998 |pmid= 9703429 |doi=
*cite journal | author=Nishihara S, Hiraga T, Ikehara Y, "et al." |title=Molecular behavior of mutant Lewis enzymes in vivo. |journal=Glycobiology |volume=9 |issue= 4 |pages= 373–82 |year= 1999 |pmid= 10089211 |doi=
*cite journal | author=Yazawa S, Tanaka S, Nishimura T, "et al." |title=Plasma alpha1,3-fucosyltransferase deficiency in schizophrenia. |journal=Exp. Clin. Immunogenet. |volume=16 |issue= 3 |pages= 125–30 |year= 1999 |pmid= 10394050 |doi=
*cite journal | author=Holmes EH, Yen TY, Thomas S, "et al." |title=Human alpha 1,3/4 fucosyltransferases. Characterization of highly conserved cysteine residues and N-linked glycosylation sites. |journal=J. Biol. Chem. |volume=275 |issue= 32 |pages= 24237–45 |year= 2000 |pmid= 10816554 |doi= 10.1074/jbc.M000888200
*cite journal | author=Grahn A, Elmgren A, Aberg L, "et al." |title=Determination of Lewis FUT3 gene mutations by PCR using sequence-specific primers enables efficient genotyping of clinical samples. |journal=Hum. Mutat. |volume=18 |issue= 4 |pages= 358–9 |year= 2002 |pmid= 11668626 |doi= 10.1002/humu.1204
*cite journal | author=Roos C, Kolmer M, Mattila P, Renkonen R |title=Composition of Drosophila melanogaster proteome involved in fucosylated glycan metabolism. |journal=J. Biol. Chem. |volume=277 |issue= 5 |pages= 3168–75 |year= 2002 |pmid= 11698403 |doi= 10.1074/jbc.M107927200

External links

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