RPS6KA3

Ribosomal protein S6 kinase, 90kDa, polypeptide 3, also known as RPS6KA3, is a human gene.cite web | title = Entrez Gene: RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6197| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Mutations in this gene have been associated with Coffin-Lowry syndrome (CLS).cite web | title = Entrez Gene: RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6197| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Omary MB, Baxter GT, Chou CF, "et al." |title=PKC epsilon-related kinase associates with and phosphorylates cytokeratin 8 and 18. |journal=J. Cell Biol. |volume=117 |issue= 3 |pages= 583–93 |year= 1992 |pmid= 1374067 |doi=
*cite journal | author=Ku NO, Omary MB |title=Identification of the major physiologic phosphorylation site of human keratin 18: potential kinases and a role in filament reorganization. |journal=J. Cell Biol. |volume=127 |issue= 1 |pages= 161–71 |year= 1994 |pmid= 7523419 |doi=
*cite journal | author=Adams MD, Kerlavage AR, Fleischmann RD, "et al." |title=Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence. |journal=Nature |volume=377 |issue= 6547 Suppl |pages= 3–174 |year= 1995 |pmid= 7566098 |doi=
*cite journal | author=Zhao Y, Bjørbaek C, Weremowicz S, "et al." |title=RSK3 encodes a novel pp90rsk isoform with a unique N-terminal sequence: growth factor-stimulated kinase function and nuclear translocation. |journal=Mol. Cell. Biol. |volume=15 |issue= 8 |pages= 4353–63 |year= 1995 |pmid= 7623830 |doi=
*cite journal | author=Bjørbaek C, Vik TA, Echwald SM, "et al." |title=Cloning of a human insulin-stimulated protein kinase (ISPK-1) gene and analysis of coding regions and mRNA levels of the ISPK-1 and the protein phosphatase-1 genes in muscle from NIDDM patients. |journal=Diabetes |volume=44 |issue= 1 |pages= 90–7 |year= 1995 |pmid= 7813820 |doi=
*cite journal | author=Donnelly AJ, Choo KH, Kozman HM, "et al." |title=Regional localisation of a non-specific X-linked mental retardation gene (MRX19) to Xp22. |journal=Am. J. Med. Genet. |volume=51 |issue= 4 |pages= 581–5 |year= 1994 |pmid= 7943043 |doi= 10.1002/ajmg.1320510457
*cite journal | author=Moller DE, Xia CH, Tang W, "et al." |title=Human rsk isoforms: cloning and characterization of tissue-specific expression. |journal=Am. J. Physiol. |volume=266 |issue= 2 Pt 1 |pages= C351–9 |year= 1994 |pmid= 8141249 |doi=
*cite journal | author=Xing J, Ginty DD, Greenberg ME |title=Coupling of the RAS-MAPK pathway to gene activation by RSK2, a growth factor-regulated CREB kinase. |journal=Science |volume=273 |issue= 5277 |pages= 959–63 |year= 1996 |pmid= 8688081 |doi=
*cite journal | author=Trivier E, De Cesare D, Jacquot S, "et al." |title=Mutations in the kinase Rsk-2 associated with Coffin-Lowry syndrome. |journal=Nature |volume=384 |issue= 6609 |pages= 567–70 |year= 1997 |pmid= 8955270 |doi= 10.1038/384567a0
*cite journal | author=Paudel HK |title=Phosphorylation by neuronal cdc2-like protein kinase promotes dimerization of Tau protein in vitro. |journal=J. Biol. Chem. |volume=272 |issue= 45 |pages= 28328–34 |year= 1997 |pmid= 9353289 |doi=
*cite journal | author=Joel PB, Smith J, Sturgill TW, "et al." |title=pp90rsk1 regulates estrogen receptor-mediated transcription through phosphorylation of Ser-167. |journal=Mol. Cell. Biol. |volume=18 |issue= 4 |pages= 1978–84 |year= 1998 |pmid= 9528769 |doi=
*cite journal | author=Zheng-Fischhöfer Q, Biernat J, Mandelkow EM, "et al." |title=Sequential phosphorylation of Tau by glycogen synthase kinase-3beta and protein kinase A at Thr212 and Ser214 generates the Alzheimer-specific epitope of antibody AT100 and requires a paired-helical-filament-like conformation. |journal=Eur. J. Biochem. |volume=252 |issue= 3 |pages= 542–52 |year= 1998 |pmid= 9546672 |doi=
*cite journal | author=Deak M, Clifton AD, Lucocq LM, Alessi DR |title=Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB. |journal=EMBO J. |volume=17 |issue= 15 |pages= 4426–41 |year= 1998 |pmid= 9687510 |doi= 10.1093/emboj/17.15.4426
*cite journal | author=Du K, Montminy M |title=CREB is a regulatory target for the protein kinase Akt/PKB. |journal=J. Biol. Chem. |volume=273 |issue= 49 |pages= 32377–9 |year= 1999 |pmid= 9829964 |doi=
*cite journal | author=Hanger DP, Betts JC, Loviny TL, "et al." |title=New phosphorylation sites identified in hyperphosphorylated tau (paired helical filament-tau) from Alzheimer's disease brain using nanoelectrospray mass spectrometry. |journal=J. Neurochem. |volume=71 |issue= 6 |pages= 2465–76 |year= 1998 |pmid= 9832145 |doi=
*cite journal | author=Jacquot S, Merienne K, De Cesare D, "et al." |title=Mutation analysis of the RSK2 gene in Coffin-Lowry patients: extensive allelic heterogeneity and a high rate of de novo mutations. |journal=Am. J. Hum. Genet. |volume=63 |issue= 6 |pages= 1631–40 |year= 1999 |pmid= 9837815 |doi=
*cite journal | author=Jacquot S, Merienne K, Pannetier S, "et al." |title=Germline mosaicism in Coffin-Lowry syndrome. |journal=Eur. J. Hum. Genet. |volume=6 |issue= 6 |pages= 578–82 |year= 1999 |pmid= 9887375 |doi= 10.1038/sj.ejhg.5200230
*cite journal | author=Smith JA, Poteet-Smith CE, Malarkey K, Sturgill TW |title=Identification of an extracellular signal-regulated kinase (ERK) docking site in ribosomal S6 kinase, a sequence critical for activation by ERK in vivo. |journal=J. Biol. Chem. |volume=274 |issue= 5 |pages= 2893–8 |year= 1999 |pmid= 9915826 |doi=
*cite journal | author=Abidi F, Jacquot S, Lassiter C, "et al." |title=Novel mutations in Rsk-2, the gene for Coffin-Lowry syndrome (CLS). |journal=Eur. J. Hum. Genet. |volume=7 |issue= 1 |pages= 20–6 |year= 1999 |pmid= 10094187 |doi= 10.1038/sj.ejhg.5200231
*cite journal | author=Merienne K, Jacquot S, Pannetier S, "et al." |title=A missense mutation in RPS6KA3 (RSK2) responsible for non-specific mental retardation. |journal=Nat. Genet. |volume=22 |issue= 1 |pages= 13–4 |year= 1999 |pmid= 10319851 |doi= 10.1038/8719

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