CDKN2B

Cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4), also known as CDKN2B, is a human gene.cite web | title = Entrez Gene: CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1030| accessdate = ]

PBB_Summary
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summary_text = This gene lies adjacent to the tumor suppressor gene CDKN2A in a region that is frequently mutated and deleted in a wide variety of tumors. This gene encodes a cyclin-dependent kinase inhibitor, which forms a complex with CDK4 or CDK6, and prevents the activation of the CDK kinases, thus the encoded protein functions as a cell growth regulator that controls cell cycle G1 progression. The expression of this gene was found to be dramatically induced by TGF beta, which suggested its role in the TGF beta induced growth inhibition. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported.cite web | title = Entrez Gene: CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1030| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Hall M, Bates S, Peters G |title=Evidence for different modes of action of cyclin-dependent kinase inhibitors: p15 and p16 bind to kinases, p21 and p27 bind to cyclins. |journal=Oncogene |volume=11 |issue= 8 |pages= 1581–8 |year= 1995 |pmid= 7478582 |doi=
*cite journal | author=Stone S, Dayananth P, Jiang P, "et al." |title=Genomic structure, expression and mutational analysis of the P15 (MTS2) gene. |journal=Oncogene |volume=11 |issue= 5 |pages= 987–91 |year= 1995 |pmid= 7675459 |doi=
*cite journal | author=Okamoto A, Hussain SP, Hagiwara K, "et al." |title=Mutations in the p16INK4/MTS1/CDKN2, p15INK4B/MTS2, and p18 genes in primary and metastatic lung cancer. |journal=Cancer Res. |volume=55 |issue= 7 |pages= 1448–51 |year= 1995 |pmid= 7882351 |doi=
*cite journal | author=Jen J, Harper JW, Bigner SH, "et al." |title=Deletion of p16 and p15 genes in brain tumors. |journal=Cancer Res. |volume=54 |issue= 24 |pages= 6353–8 |year= 1995 |pmid= 7987828 |doi=
*cite journal | author=Guan KL, Jenkins CW, Li Y, "et al." |title=Growth suppression by p18, a p16INK4/MTS1- and p14INK4B/MTS2-related CDK6 inhibitor, correlates with wild-type pRb function. |journal=Genes Dev. |volume=8 |issue= 24 |pages= 2939–52 |year= 1995 |pmid= 8001816 |doi=
*cite journal | author=Hannon GJ, Beach D |title=p15INK4B is a potential effector of TGF-beta-induced cell cycle arrest. |journal=Nature |volume=371 |issue= 6494 |pages= 257–61 |year= 1994 |pmid= 8078588 |doi= 10.1038/371257a0
*cite journal | author=Kamb A, Gruis NA, Weaver-Feldhaus J, "et al." |title=A cell cycle regulator potentially involved in genesis of many tumor types. |journal=Science |volume=264 |issue= 5157 |pages= 436–40 |year= 1994 |pmid= 8153634 |doi=
*cite journal | author=Reynisdóttir I, Massagué J |title=The subcellular locations of p15(Ink4b) and p27(Kip1) coordinate their inhibitory interactions with cdk4 and cdk2. |journal=Genes Dev. |volume=11 |issue= 4 |pages= 492–503 |year= 1997 |pmid= 9042862 |doi=
*cite journal | author=Sandhu C, Garbe J, Bhattacharya N, "et al." |title=Transforming growth factor beta stabilizes p15INK4B protein, increases p15INK4B-cdk4 complexes, and inhibits cyclin D1-cdk4 association in human mammary epithelial cells. |journal=Mol. Cell. Biol. |volume=17 |issue= 5 |pages= 2458–67 |year= 1997 |pmid= 9111314 |doi=
*cite journal | author=Iavarone A, Massagué J |title=Repression of the CDK activator Cdc25A and cell-cycle arrest by cytokine TGF-beta in cells lacking the CDK inhibitor p15. |journal=Nature |volume=387 |issue= 6631 |pages= 417–22 |year= 1997 |pmid= 9163429 |doi= 10.1038/387417a0
*cite journal | author=Tsubari M, Tiihonen E, Laiho M |title=Cloning and characterization of p10, an alternatively spliced form of p15 cyclin-dependent kinase inhibitor. |journal=Cancer Res. |volume=57 |issue= 14 |pages= 2966–73 |year= 1997 |pmid= 9230210 |doi=
*cite journal | author=Rich JN, Zhang M, Datto MB, "et al." |title=Transforming growth factor-beta-mediated p15(INK4B) induction and growth inhibition in astrocytes is SMAD3-dependent and a pathway prominently altered in human glioma cell lines. |journal=J. Biol. Chem. |volume=274 |issue= 49 |pages= 35053–8 |year= 2000 |pmid= 10574984 |doi=
*cite journal | author=Yuan C, Selby TL, Li J, "et al." |title=Tumor suppressor INK4: refinement of p16INK4A structure and determination of p15INK4B structure by comparative modeling and NMR data. |journal=Protein Sci. |volume=9 |issue= 6 |pages= 1120–8 |year= 2000 |pmid= 10892805 |doi=
*cite journal | author=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination. |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788–95 |year= 2001 |pmid= 11076863 |doi=
*cite journal | author=Staller P, Peukert K, Kiermaier A, "et al." |title=Repression of p15INK4b expression by Myc through association with Miz-1. |journal=Nat. Cell Biol. |volume=3 |issue= 4 |pages= 392–9 |year= 2001 |pmid= 11283613 |doi= 10.1038/35070076
*cite journal | author=Orlow I, Cordon-Cardo C |title=Evaluation of alterations in the tumor suppressor genes INK4A and INK4B in human bladder tumors. |journal=Methods Mol. Biol. |volume=179 |issue= |pages= 43–59 |year= 2002 |pmid= 11692873 |doi=
*cite journal | author=Agiostratidou G, Derventzi A, Gonos ES |title=Over-expression of CDKIs p15INK4b, p16INK4a and p21CIP1/WAF1 genes mediate growth arrest in human osteosarcoma cell lines. |journal=In Vivo |volume=15 |issue= 5 |pages= 443–6 |year= 2002 |pmid= 11695244 |doi=
*cite journal | author=Simon M, Park TW, Köster G, "et al." |title=Alterations of INK4a(p16-p14ARF)/INK4b(p15) expression and telomerase activation in meningioma progression. |journal=J. Neurooncol. |volume=55 |issue= 3 |pages= 149–58 |year= 2002 |pmid= 11859969 |doi=
*cite journal | author=Scarisbrick JJ, Woolford AJ, Calonje E, "et al." |title=Frequent abnormalities of the p15 and p16 genes in mycosis fungoides and sezary syndrome. |journal=J. Invest. Dermatol. |volume=118 |issue= 3 |pages= 493–9 |year= 2002 |pmid= 11874489 |doi= 10.1046/j.0022-202x.2001.01682.x
*cite journal | author=Kudoh K, Ichikawa Y, Yoshida S, "et al." |title=Inactivation of p16/CDKN2 and p15/MTS2 is associated with prognosis and response to chemotherapy in ovarian cancer. |journal=Int. J. Cancer |volume=99 |issue= 4 |pages= 579–82 |year= 2002 |pmid= 11992549 |doi= 10.1002/ijc.10331

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