ABCC2


ABCC2

ATP-binding cassette, sub-family C (CFTR/MRP), member 2, also known as ABCC2, is a human gene.cite web | title = Entrez Gene: ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1244| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily, which is involved in multi-drug resistance. This protein is expressed in the canalicular (apical) part of the hepatocyte and functions in biliary transport. Substrates include anticancer drugs such as vinblastine; therefore, this protein appears to contribute to drug resistance in mammalian cells. Several different mutations in this gene have been observed in patients with Dubin-Johnson syndrome (DJS), an autosomal recessive disorder characterized by conjugated hyperbilirubinemia.cite web | title = Entrez Gene: ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1244| accessdate = ]

ee also

* ATP-binding cassette transporter

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Keppler D, König J |title=Hepatic secretion of conjugated drugs and endogenous substances. |journal=Semin. Liver Dis. |volume=20 |issue= 3 |pages= 265–72 |year= 2001 |pmid= 11076395 |doi=
*cite journal | author=Gerk PM, Vore M |title=Regulation of expression of the multidrug resistance-associated protein 2 (MRP2) and its role in drug disposition. |journal=J. Pharmacol. Exp. Ther. |volume=302 |issue= 2 |pages= 407–15 |year= 2002 |pmid= 12130697 |doi= 10.1124/jpet.102.035014
*cite journal | author=Mayer R, Kartenbeck J, Büchler M, "et al." |title=Expression of the MRP gene-encoded conjugate export pump in liver and its selective absence from the canalicular membrane in transport-deficient mutant hepatocytes. |journal=J. Cell Biol. |volume=131 |issue= 1 |pages= 137–50 |year= 1995 |pmid= 7559771 |doi=
*cite journal | author=Büchler M, König J, Brom M, "et al." |title=cDNA cloning of the hepatocyte canalicular isoform of the multidrug resistance protein, cMrp, reveals a novel conjugate export pump deficient in hyperbilirubinemic mutant rats. |journal=J. Biol. Chem. |volume=271 |issue= 25 |pages= 15091–8 |year= 1996 |pmid= 8662992 |doi=
*cite journal | author=Taniguchi K, Wada M, Kohno K, "et al." |title=A human canalicular multispecific organic anion transporter (cMOAT) gene is overexpressed in cisplatin-resistant human cancer cell lines with decreased drug accumulation. |journal=Cancer Res. |volume=56 |issue= 18 |pages= 4124–9 |year= 1996 |pmid= 8797578 |doi=
*cite journal | author=Paulusma CC, Kool M, Bosma PJ, "et al." |title=A mutation in the human canalicular multispecific organic anion transporter gene causes the Dubin-Johnson syndrome. |journal=Hepatology |volume=25 |issue= 6 |pages= 1539–42 |year= 1997 |pmid= 9185779 |doi= 10.1002/hep.510250635
*cite journal | author=van Kuijck MA, Kool M, Merkx GF, "et al." |title=Assignment of the canalicular multispecific organic anion transporter gene (CMOAT) to human chromosome 10q24 and mouse chromosome 19D2 by fluorescent in situ hybridization. |journal=Cytogenet. Cell Genet. |volume=77 |issue= 3-4 |pages= 285–7 |year= 1997 |pmid= 9284939 |doi=
*cite journal | author=Wada M, Toh S, Taniguchi K, "et al." |title=Mutations in the canilicular multispecific organic anion transporter (cMOAT) gene, a novel ABC transporter, in patients with hyperbilirubinemia II/Dubin-Johnson syndrome. |journal=Hum. Mol. Genet. |volume=7 |issue= 2 |pages= 203–7 |year= 1998 |pmid= 9425227 |doi=
*cite journal | author=Evers R, Kool M, van Deemter L, "et al." |title=Drug export activity of the human canalicular multispecific organic anion transporter in polarized kidney MDCK cells expressing cMOAT (MRP2) cDNA. |journal=J. Clin. Invest. |volume=101 |issue= 7 |pages= 1310–9 |year= 1998 |pmid= 9525973 |doi=
*cite journal | author=Kajihara S, Hisatomi A, Mizuta T, "et al." |title=A splice mutation in the human canalicular multispecific organic anion transporter gene causes Dubin-Johnson syndrome. |journal=Biochem. Biophys. Res. Commun. |volume=253 |issue= 2 |pages= 454–7 |year= 1999 |pmid= 9878557 |doi= 10.1006/bbrc.1998.9780
*cite journal | author=Toh S, Wada M, Uchiumi T, "et al." |title=Genomic structure of the canalicular multispecific organic anion-transporter gene (MRP2/cMOAT) and mutations in the ATP-binding-cassette region in Dubin-Johnson syndrome. |journal=Am. J. Hum. Genet. |volume=64 |issue= 3 |pages= 739–46 |year= 1999 |pmid= 10053008 |doi=
*cite journal | author=Schaub TP, Kartenbeck J, König J, "et al." |title=Expression of the MRP2 gene-encoded conjugate export pump in human kidney proximal tubules and in renal cell carcinoma. |journal=J. Am. Soc. Nephrol. |volume=10 |issue= 6 |pages= 1159–69 |year= 1999 |pmid= 10361853 |doi=
*cite journal | author=Tsujii H, König J, Rost D, "et al." |title=Exon-intron organization of the human multidrug-resistance protein 2 (MRP2) gene mutated in Dubin-Johnson syndrome. |journal=Gastroenterology |volume=117 |issue= 3 |pages= 653–60 |year= 1999 |pmid= 10464142 |doi=
*cite journal | author=Kocher O, Comella N, Gilchrist A, "et al." |title=PDZK1, a novel PDZ domain-containing protein up-regulated in carcinomas and mapped to chromosome 1q21, interacts with cMOAT (MRP2), the multidrug resistance-associated protein. |journal=Lab. Invest. |volume=79 |issue= 9 |pages= 1161–70 |year= 1999 |pmid= 10496535 |doi=
*cite journal | author=Tanaka T, Uchiumi T, Hinoshita E, "et al." |title=The human multidrug resistance protein 2 gene: functional characterization of the 5'-flanking region and expression in hepatic cells. |journal=Hepatology |volume=30 |issue= 6 |pages= 1507–12 |year= 1999 |pmid= 10573531 |doi= 10.1002/hep.510300617
*cite journal | author=St-Pierre MV, Serrano MA, Macias RI, "et al." |title=Expression of members of the multidrug resistance protein family in human term placenta. |journal=Am. J. Physiol. Regul. Integr. Comp. Physiol. |volume=279 |issue= 4 |pages= R1495–503 |year= 2000 |pmid= 11004020 |doi=
*cite journal | author=Keitel V, Kartenbeck J, Nies AT, "et al." |title=Impaired protein maturation of the conjugate export pump multidrug resistance protein 2 as a consequence of a deletion mutation in Dubin-Johnson syndrome. |journal=Hepatology |volume=32 |issue= 6 |pages= 1317–28 |year= 2001 |pmid= 11093739 |doi= 10.1053/jhep.2000.19791
*cite journal | author=Ito S, Ieiri I, Tanabe M, "et al." |title=Polymorphism of the ABC transporter genes, MDR1, MRP1 and MRP2/cMOAT, in healthy Japanese subjects. |journal=Pharmacogenetics |volume=11 |issue= 2 |pages= 175–84 |year= 2001 |pmid= 11266082 |doi=
*cite journal | author=Mor-Cohen R, Zivelin A, Rosenberg N, "et al." |title=Identification and functional analysis of two novel mutations in the multidrug resistance protein 2 gene in Israeli patients with Dubin-Johnson syndrome. |journal=J. Biol. Chem. |volume=276 |issue= 40 |pages= 36923–30 |year= 2001 |pmid= 11477083 |doi= 10.1074/jbc.M105047200

External links

*

PBB_Controls
update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = yes
update_citations = yes


Wikimedia Foundation. 2010.

Look at other dictionaries:

  • Multidrug resistance-associated protein 2 — ATP binding cassette, sub family C (CFTR/MRP), member 2 Identifiers Symbols ABCC2; ABC30; CMOAT; DJS; KIAA1010; MRP2; cMRP External IDs …   Wikipedia

  • Cystic fibrosis — Classification and external resources A breathing treatment for cystic fibrosis, using a mask nebuliser and a ThAIRapy Vest ICD 10 E …   Wikipedia

  • Adrenoleukodystrophy — Classification and external resources T2 weighted axial scan at the level of the caudate heads demonstrates marked loss of posterior white matter, with reduced volume and increased signal intensity. The anterior white matter is spared. Features… …   Wikipedia

  • Dilated cardiomyopathy — Classification and external resources ICD 10 I42.0 ICD 9 425.4 …   Wikipedia

  • Progressive familial intrahepatic cholestasis — Classification and external resources OMIM 211600 601847 602347 DiseasesDB …   Wikipedia

  • Tangier disease — Classification and external resources ICD 10 E78.6 ICD 9 272.5 …   Wikipedia

  • CEBPB — CCAAT/enhancer binding protein (C/EBP), beta PDB rendering based on 1ci6 …   Wikipedia

  • ATP-binding domain of ABC transporters — Pfam box Symbol = ABC tran Name = width = caption =Multidrug ABC transporter SAV1866, closed state Pfam= PF00005 InterPro= IPR003439 SMART= PROSITE = PDOC00185 SCOP = 1b0u TCDB = 3.A.1 OPM family= 17 OPM protein=2hyd PDB=PDB3|1vplA:29 210… …   Wikipedia

  • Transmembrane domain of ABC transporters — Pfam box Symbol = ABC membrane Name = ABC transporter transmembrane region width = caption = Pfam= PF00664 InterPro= IPR001140 SMART= PROSITE = PDOC00364 SCOP = 1pf4 TCDB = 3.A.1 OPM family= 18 OPM protein= 1pf4 PDB=ABC transporter transmembrane… …   Wikipedia

  • Glycoproteine P — Glycoprotéine P Pour les articles homonymes, voir PGP (homonymie). La glycoprotéine P, aussi appelée PGP, est une glycoprotéine provoquant un phénomène de multirésistance aux médicaments (multi drug resistance en anglais). Découverte dans les… …   Wikipédia en Français


Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”

We are using cookies for the best presentation of our site. Continuing to use this site, you agree with this.