- FGR (gene)
Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog, also known as FGR, is a human
gene .cite web | title = Entrez Gene: FGR Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2268| accessdate = ]PBB_Summary
section_title =
summary_text = This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to plasma membrane ruffles, and functions as a negative regulator of cell migration and adhesion triggered by the beta-2 integrin signal transduction pathway. Infection with Epstein-Barr virus results in the overexpression of this gene. Multiple alternatively spliced variants, encoding the same protein, have been identified.cite web | title = Entrez Gene: FGR Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2268| accessdate = ]References
Further reading
PBB_Further_reading
citations =
*cite journal | author=Patel M, Faulkner L, Katz DR, Brickell PM |title=The c-fgr proto-oncogene: expression in Epstein-Barr-virus-infected B lymphocytes and in cells of the myelomonocytic and granulocytic lineages. |journal=Pathobiology |volume=59 |issue= 4 |pages= 289–92 |year= 1991 |pmid= 1652975 |doi=
*cite journal | author=Resh MD |title=Myristylation and palmitylation of Src family members: the fats of the matter. |journal=Cell |volume=76 |issue= 3 |pages= 411–3 |year= 1994 |pmid= 8313462 |doi=
*cite journal | author=Lowell CA, Berton G |title=Integrin signal transduction in myeloid leukocytes. |journal=J. Leukoc. Biol. |volume=65 |issue= 3 |pages= 313–20 |year= 1999 |pmid= 10080533 |doi=
*cite journal | author=Snapper SB, Rosen FS |title=The Wiskott-Aldrich syndrome protein (WASP): roles in signaling and cytoskeletal organization. |journal=Annu. Rev. Immunol. |volume=17 |issue= |pages= 905–29 |year= 1999 |pmid= 10358777 |doi= 10.1146/annurev.immunol.17.1.905
*cite journal | author=Tatosyan AG, Mizenina OA |title=Kinases of the Src family: structure and functions. |journal=Biochemistry Mosc. |volume=65 |issue= 1 |pages= 49–58 |year= 2000 |pmid= 10702640 |doi=
*cite journal | author=Patel MS, Mankoo BS, Brickell PM |title=A polymorphic microsatellite repeat is located close to the promoter region of the c-fgr proto-oncogene (FGR) at chromosome 1p36.2-p36.1. |journal=Hum. Mol. Genet. |volume=1 |issue= 1 |pages= 65 |year= 1993 |pmid= 1339476 |doi=
*cite journal | author=Link DC, Gutkind SJ, Robbins KC, Ley TJ |title=Characterization of the 5' untranslated region of the human c-fgr gene and identification of the major myelomonocytic c-fgr promoter. |journal=Oncogene |volume=7 |issue= 5 |pages= 877–84 |year= 1992 |pmid= 1373875 |doi=
*cite journal | author=Patel M, Leevers SJ, Brickell PM |title=Structure of the complete human c-fgr proto-oncogene and identification of multiple transcriptional start sites. |journal=Oncogene |volume=5 |issue= 2 |pages= 201–6 |year= 1990 |pmid= 1690869 |doi=
*cite journal | author=Biondi A, Paganin C, Rossi V, "et al." |title=Expression of lineage-restricted protein tyrosine kinase genes in human natural killer cells. |journal=Eur. J. Immunol. |volume=21 |issue= 3 |pages= 843–6 |year= 1991 |pmid= 1826268 |doi=
*cite journal | author=Gutkind JS, Link DC, Katamine S, "et al." |title=A novel c-fgr exon utilized in Epstein-Barr virus-infected B lymphocytes but not in normal monocytes. |journal=Mol. Cell. Biol. |volume=11 |issue= 3 |pages= 1500–7 |year= 1991 |pmid= 1847500 |doi=
*cite journal | author=Patel M, Leevers SJ, Brickell PM |title=Regulation of c-fgr proto-oncogene expression in Epstein-Barr virus infected B-cell lines. |journal=Int. J. Cancer |volume=45 |issue= 2 |pages= 342–6 |year= 1990 |pmid= 2154410 |doi=
*cite journal | author=Parker RC, Mardon G, Lebo RV, "et al." |title=Isolation of duplicated human c-src genes located on chromosomes 1 and 20. |journal=Mol. Cell. Biol. |volume=5 |issue= 4 |pages= 831–8 |year= 1985 |pmid= 2581127 |doi=
*cite journal | author=Brickell PM, Patel M |title=Structure and expression of c-fgr protooncogene mRNA in Epstein-Barr virus converted cell lines. |journal=Br. J. Cancer |volume=58 |issue= 6 |pages= 704–9 |year= 1989 |pmid= 2852026 |doi=
*cite journal | author=Tronick SR, Popescu NC, Cheah MS, "et al." |title=Isolation and chromosomal localization of the human fgr protooncogene, a distinct member of the tyrosine kinase gene family. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=82 |issue= 19 |pages= 6595–9 |year= 1985 |pmid= 2995972 |doi=
*cite journal | author=Cheah MS, Ley TJ, Tronick SR, Robbins KC |title=fgr proto-oncogene mRNA induced in B lymphocytes by Epstein-Barr virus infection. |journal=Nature |volume=319 |issue= 6050 |pages= 238–40 |year= 1986 |pmid= 3003578 |doi= 10.1038/319238a0
*cite journal | author=Nishizawa M, Semba K, Yoshida MC, "et al." |title=Structure, expression, and chromosomal location of the human c-fgr gene. |journal=Mol. Cell. Biol. |volume=6 |issue= 2 |pages= 511–7 |year= 1987 |pmid= 3023853 |doi=
*cite journal | author=Katamine S, Notario V, Rao CD, "et al." |title=Primary structure of the human fgr proto-oncogene product p55c-fgr. |journal=Mol. Cell. Biol. |volume=8 |issue= 1 |pages= 259–66 |year= 1988 |pmid= 3275868 |doi=
*cite journal | author=Inoue K, Ikawa S, Semba K, "et al." |title=Isolation and sequencing of cDNA clones homologous to the v-fgr oncogene from a human B lymphocyte cell line, IM-9. |journal=Oncogene |volume=1 |issue= 3 |pages= 301–4 |year= 1988 |pmid= 3330776 |doi=
*cite journal | author=Nishizawa M, Semba K, Yamamoto T, Toyoshima K |title=Human c-f gr gene does not contain coding sequence for actin-like protein. |journal=Jpn. J. Cancer Res. |volume=76 |issue= 3 |pages= 155–9 |year= 1985 |pmid= 3922831 |doi=PBB_Controls
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