CD47

CD47 (Cluster of Differentiation 47) is a human protein encoded by the gene|CD47 gene.cite web | title = Entrez Gene: CD47 CD47 molecule| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=961| accessdate = ]

PBB_Summary
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summary_text = This gene encodes a membrane protein, which is involved in the increase in intracellular calcium concentration that occurs upon cell adhesion to extracellular matrix. The encoded protein is also a receptor for the C-terminal cell binding domain of thrombospondin, and it may play a role in membrane transport and signal transduction. This gene has broad tissue distribution, and is reduced in expression on Rh erythrocytes. Four alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. cite web | title = Entrez Gene: CD47 CD47 molecule| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=961| accessdate = ] Isoform 2 and 4 are the most abundant. Other than thrombospondin, CD47 also binds CD172a. CD47 deficient mice have been generated. Their reported phenotype is a defect in cellular migration of the CD172a expressing cells, suggesting that CD47 to CD172a interactions are necessary for the proper distribution of these cell types.

ee also

* Cluster of differentiation

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Brown EJ, Frazier WA |title=Integrin-associated protein (CD47) and its ligands. |journal=Trends Cell Biol. |volume=11 |issue= 3 |pages= 130–5 |year= 2001 |pmid= 11306274 |doi=
*cite journal | author=Oldenborg PA |title=Role of CD47 in erythroid cells and in autoimmunity. |journal=Leuk. Lymphoma |volume=45 |issue= 7 |pages= 1319–27 |year= 2004 |pmid= 15359629 |doi= 10.1080/1042819042000201989
*cite journal | author=Kaczorowski DJ, Billiar TR |title=Targeting CD47: NO limit on therapeutic potential. |journal=Circ. Res. |volume=100 |issue= 5 |pages= 602–3 |year= 2007 |pmid= 17363705 |doi= 10.1161/01.RES.0000261609.44977.25
*cite journal | author=Campbell IG, Freemont PS, Foulkes W, Trowsdale J |title=An ovarian tumor marker with homology to vaccinia virus contains an IgV-like region and multiple transmembrane domains. |journal=Cancer Res. |volume=52 |issue= 19 |pages= 5416–20 |year= 1992 |pmid= 1394148 |doi=
*cite journal | author=Brown E, Hooper L, Ho T, Gresham H |title=Integrin-associated protein: a 50-kD plasma membrane antigen physically and functionally associated with integrins. |journal=J. Cell Biol. |volume=111 |issue= 6 Pt 1 |pages= 2785–94 |year= 1991 |pmid= 2277087 |doi=
*cite journal | author=Lindberg FP, Gresham HD, Schwarz E, Brown EJ |title=Molecular cloning of integrin-associated protein: an immunoglobulin family member with multiple membrane-spanning domains implicated in alpha v beta 3-dependent ligand binding. |journal=J. Cell Biol. |volume=123 |issue= 2 |pages= 485–96 |year= 1993 |pmid= 7691831 |doi=
*cite journal | author=Mawby WJ, Holmes CH, Anstee DJ, "et al." |title=Isolation and characterization of CD47 glycoprotein: a multispanning membrane protein which is the same as integrin-associated protein (IAP) and the ovarian tumour marker OA3. |journal=Biochem. J. |volume=304 ( Pt 2) |issue= |pages= 525–30 |year= 1995 |pmid= 7998989 |doi=
*cite journal | author=Lindberg FP, Lublin DM, Telen MJ, "et al." |title=Rh-related antigen CD47 is the signal-transducer integrin-associated protein. |journal=J. Biol. Chem. |volume=269 |issue= 3 |pages= 1567–70 |year= 1994 |pmid= 8294396 |doi=
*cite journal | author=Gao AG, Lindberg FP, Finn MB, "et al." |title=Integrin-associated protein is a receptor for the C-terminal domain of thrombospondin. |journal=J. Biol. Chem. |volume=271 |issue= 1 |pages= 21–4 |year= 1996 |pmid= 8550562 |doi=
*cite journal | author=Cherif-Zahar B, Raynal V, Gane P, "et al." |title=Candidate gene acting as a suppressor of the RH locus in most cases of Rh-deficiency. |journal=Nat. Genet. |volume=12 |issue= 2 |pages= 168–73 |year= 1996 |pmid= 8563755 |doi= 10.1038/ng0296-168
*cite journal | author=Chung J, Gao AG, Frazier WA |title=Thrombspondin acts via integrin-associated protein to activate the platelet integrin alphaIIbbeta3. |journal=J. Biol. Chem. |volume=272 |issue= 23 |pages= 14740–6 |year= 1997 |pmid= 9169439 |doi=
*cite journal | author=Jiang P, Lagenaur CF, Narayanan V |title=Integrin-associated protein is a ligand for the P84 neural adhesion molecule. |journal=J. Biol. Chem. |volume=274 |issue= 2 |pages= 559–62 |year= 1999 |pmid= 9872987 |doi=
*cite journal | author=Hermann P, Armant M, Brown E, "et al." |title=The vitronectin receptor and its associated CD47 molecule mediates proinflammatory cytokine synthesis in human monocytes by interaction with soluble CD23. |journal=J. Cell Biol. |volume=144 |issue= 4 |pages= 767–75 |year= 1999 |pmid= 10037797 |doi=
*cite journal | author=Chung J, Wang XQ, Lindberg FP, Frazier WA |title=Thrombospondin-1 acts via IAP/CD47 to synergize with collagen in alpha2beta1-mediated platelet activation. |journal=Blood |volume=94 |issue= 2 |pages= 642–8 |year= 1999 |pmid= 10397731 |doi=
*cite journal | author=Longhurst CM, White MM, Wilkinson DA, Jennings LK |title=A CD9, alphaIIbbeta3, integrin-associated protein, and GPIb/V/IX complex on the surface of human platelets is influenced by alphaIIbbeta3 conformational states. |journal=Eur. J. Biochem. |volume=263 |issue= 1 |pages= 104–11 |year= 1999 |pmid= 10429193 |doi=
*cite journal | author=Mateo V, Lagneaux L, Bron D, "et al." |title=CD47 ligation induces caspase-independent cell death in chronic lymphocytic leukemia. |journal=Nat. Med. |volume=5 |issue= 11 |pages= 1277–84 |year= 1999 |pmid= 10545994 |doi= 10.1038/15233
*cite journal | author=Wu AL, Wang J, Zheleznyak A, Brown EJ |title=Ubiquitin-related proteins regulate interaction of vimentin intermediate filaments with the plasma membrane. |journal=Mol. Cell |volume=4 |issue= 4 |pages= 619–25 |year= 1999 |pmid= 10549293 |doi=
*cite journal | author=Erb L, Liu J, Ockerhausen J, "et al." |title=An RGD sequence in the P2Y(2) receptor interacts with alpha(V)beta(3) integrins and is required for G(o)-mediated signal transduction. |journal=J. Cell Biol. |volume=153 |issue= 3 |pages= 491–501 |year= 2001 |pmid= 11331301 |doi=
*cite journal | author=Rebres RA, Vaz LE, Green JM, Brown EJ |title=Normal ligand binding and signaling by CD47 (integrin-associated protein) requires a long range disulfide bond between the extracellular and membrane-spanning domains. |journal=J. Biol. Chem. |volume=276 |issue= 37 |pages= 34607–16 |year= 2001 |pmid= 11454874 |doi= 10.1074/jbc.M106107200

External links

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