KCNMA1

Potassium large conductance calcium-activated channel, subfamily M, alpha member 1, also known as KCNMA1, is a human gene.cite web | title = Entrez Gene: KCNMA1 potassium large conductance calcium-activated channel, subfamily M, alpha member 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3778| accessdate = ]

PBB_Summary
section_title =
summary_text = MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit, which is the product of this gene, and the modulatory beta subunit. Intracellular calcium regulates the physical association between the alpha and beta subunits. Alternatively spliced transcript variants encoding different isoforms have been identified.cite web | title = Entrez Gene: KCNMA1 potassium large conductance calcium-activated channel, subfamily M, alpha member 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3778| accessdate = ]

ee also

* BK channel
* Voltage-gated potassium channel

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Magleby KL |title=Gating mechanism of BK (Slo1) channels: so near, yet so far. |journal=J. Gen. Physiol. |volume=121 |issue= 2 |pages= 81–96 |year= 2003 |pmid= 12566537 |doi=
*cite journal | author=Wei AD, Gutman GA, Aldrich R, "et al." |title=International Union of Pharmacology. LII. Nomenclature and molecular relationships of calcium-activated potassium channels. |journal=Pharmacol. Rev. |volume=57 |issue= 4 |pages= 463–72 |year= 2006 |pmid= 16382103 |doi= 10.1124/pr.57.4.9
*cite journal | author=McCobb DP, Fowler NL, Featherstone T, "et al." |title=A human calcium-activated potassium channel gene expressed in vascular smooth muscle. |journal=Am. J. Physiol. |volume=269 |issue= 3 Pt 2 |pages= H767–77 |year= 1995 |pmid= 7573516 |doi=
*cite journal | author=Butler A, Tsunoda S, McCobb DP, "et al." |title=mSlo, a complex mouse gene encoding "maxi" calcium-activated potassium channels. |journal=Science |volume=261 |issue= 5118 |pages= 221–4 |year= 1993 |pmid= 7687074 |doi=
*cite journal | author=Dworetzky SI, Trojnacki JT, Gribkoff VK |title=Cloning and expression of a human large-conductance calcium-activated potassium channel. |journal=Brain Res. Mol. Brain Res. |volume=27 |issue= 1 |pages= 189–93 |year= 1995 |pmid= 7877450 |doi=
*cite journal | author=Pallanck L, Ganetzky B |title=Cloning and characterization of human and mouse homologs of the Drosophila calcium-activated potassium channel gene, slowpoke. |journal=Hum. Mol. Genet. |volume=3 |issue= 8 |pages= 1239–43 |year= 1995 |pmid= 7987297 |doi=
*cite journal | author=Tseng-Crank J, Foster CD, Krause JD, "et al." |title=Cloning, expression, and distribution of functionally distinct Ca(2+)-activated K+ channel isoforms from human brain. |journal=Neuron |volume=13 |issue= 6 |pages= 1315–30 |year= 1995 |pmid= 7993625 |doi=
*cite journal | author=Knaus HG, Folander K, Garcia-Calvo M, "et al." |title=Primary sequence and immunological characterization of beta-subunit of high conductance Ca(2+)-activated K+ channel from smooth muscle. |journal=J. Biol. Chem. |volume=269 |issue= 25 |pages= 17274–8 |year= 1994 |pmid= 8006036 |doi=
*cite journal | author=Meera P, Wallner M, Jiang Z, Toro L |title=A calcium switch for the functional coupling between alpha (hslo) and beta subunits (KV,Ca beta) of maxi K channels. |journal=FEBS Lett. |volume=382 |issue= 1-2 |pages= 84–8 |year= 1996 |pmid= 8612769 |doi=
*cite journal | author=Wallner M, Meera P, Ottolia M, "et al." |title=Characterization of and modulation by a beta-subunit of a human maxi KCa channel cloned from myometrium. |journal=Recept. Channels |volume=3 |issue= 3 |pages= 185–99 |year= 1996 |pmid= 8821792 |doi=
*cite journal | author=Wallner M, Meera P, Toro L |title=Determinant for beta-subunit regulation in high-conductance voltage-activated and Ca(2+)-sensitive K+ channels: an additional transmembrane region at the N terminus. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 25 |pages= 14922–7 |year= 1997 |pmid= 8962157 |doi=
*cite journal | author=Meera P, Wallner M, Song M, Toro L |title=Large conductance voltage- and calcium-dependent K+ channel, a distinct member of voltage-dependent ion channels with seven N-terminal transmembrane segments (S0-S6), an extracellular N terminus, and an intracellular (S9-S10) C terminus. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 25 |pages= 14066–71 |year= 1998 |pmid= 9391153 |doi=
*cite journal | author=Díaz L, Meera P, Amigo J, "et al." |title=Role of the S4 segment in a voltage-dependent calcium-sensitive potassium (hSlo) channel. |journal=J. Biol. Chem. |volume=273 |issue= 49 |pages= 32430–6 |year= 1999 |pmid= 9829973 |doi=
*cite journal | author=Wallner M, Meera P, Toro L |title=Molecular basis of fast inactivation in voltage and Ca2+-activated K+ channels: a transmembrane beta-subunit homolog. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 7 |pages= 4137–42 |year= 1999 |pmid= 10097176 |doi=
*cite journal | author=Valverde MA, Rojas P, Amigo J, "et al." |title=Acute activation of Maxi-K channels (hSlo) by estradiol binding to the beta subunit. |journal=Science |volume=285 |issue= 5435 |pages= 1929–31 |year= 1999 |pmid= 10489376 |doi=
*cite journal | author=Brenner R, Jegla TJ, Wickenden A, "et al." |title=Cloning and functional characterization of novel large conductance calcium-activated potassium channel beta subunits, hKCNMB3 and hKCNMB4. |journal=J. Biol. Chem. |volume=275 |issue= 9 |pages= 6453–61 |year= 2000 |pmid= 10692449 |doi=
*cite journal | author=Liu QH, Williams DA, McManus C, "et al." |title=HIV-1 gp120 and chemokines activate ion channels in primary macrophages through CCR5 and CXCR4 stimulation. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 9 |pages= 4832–7 |year= 2000 |pmid= 10758170 |doi= 10.1073/pnas.090521697
*cite journal | author=Quirk JC, Reinhart PH |title=Identification of a novel tetramerization domain in large conductance K(ca) channels. |journal=Neuron |volume=32 |issue= 1 |pages= 13–23 |year= 2001 |pmid= 11604135 |doi=
*cite journal | author=Soto MA, González C, Lissi E, "et al." |title=Ca(2+)-activated K+ channel inhibition by reactive oxygen species. |journal=Am. J. Physiol., Cell Physiol. |volume=282 |issue= 3 |pages= C461–71 |year= 2002 |pmid= 11832330 |doi= 10.1152/ajpcell.00167.2001
*cite journal | author=Wang YW, Ding JP, Xia XM, Lingle CJ |title=Consequences of the stoichiometry of Slo1 alpha and auxiliary beta subunits on functional properties of large-conductance Ca2+-activated K+ channels. |journal=J. Neurosci. |volume=22 |issue= 5 |pages= 1550–61 |year= 2002 |pmid= 11880485 |doi=

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