HLA-F

HLA-F

Major histocompatibility complex, class I, F, also known as HLA-F, is a human gene.cite web | title = Entrez Gene: HLA-F major histocompatibility complex, class I, F| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3134| accessdate = ]

PBB_Summary
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summary_text = HLA-F belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. HLA-F binds a restricted subset of peptides derived from the leader peptides of other class I molecules. The heavy chain is approximately 42 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region and exons 6 and 7 encode the cytoplasmic tail. The HLA-F gene exhibits few polymorphisms.cite web | title = Entrez Gene: HLA-F major histocompatibility complex, class I, F| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3134| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Geyer M, Fackler OT, Peterlin BM |title=Structure--function relationships in HIV-1 Nef. |journal=EMBO Rep. |volume=2 |issue= 7 |pages= 580–5 |year= 2001 |pmid= 11463741 |doi= 10.1093/embo-reports/kve141
*cite journal | author=Greenway AL, Holloway G, McPhee DA, "et al." |title=HIV-1 Nef control of cell signalling molecules: multiple strategies to promote virus replication. |journal=J. Biosci. |volume=28 |issue= 3 |pages= 323–35 |year= 2004 |pmid= 12734410 |doi=
*cite journal | author=Bénichou S, Benmerah A |title= [The HIV nef and the Kaposi-sarcoma-associated virus K3/K5 proteins: "parasites"of the endocytosis pathway] |journal=Med Sci (Paris) |volume=19 |issue= 1 |pages= 100–6 |year= 2003 |pmid= 12836198 |doi=
*cite journal | author=Leavitt SA, SchOn A, Klein JC, "et al." |title=Interactions of HIV-1 proteins gp120 and Nef with cellular partners define a novel allosteric paradigm. |journal=Curr. Protein Pept. Sci. |volume=5 |issue= 1 |pages= 1–8 |year= 2004 |pmid= 14965316 |doi=
*cite journal | author=Tolstrup M, Ostergaard L, Laursen AL, "et al." |title=HIV/SIV escape from immune surveillance: focus on Nef. |journal=Curr. HIV Res. |volume=2 |issue= 2 |pages= 141–51 |year= 2004 |pmid= 15078178 |doi=
*cite journal | author=Joseph AM, Kumar M, Mitra D |title=Nef: "necessary and enforcing factor" in HIV infection. |journal=Curr. HIV Res. |volume=3 |issue= 1 |pages= 87–94 |year= 2005 |pmid= 15638726 |doi=
*cite journal | author=Anderson JL, Hope TJ |title=HIV accessory proteins and surviving the host cell. |journal=Current HIV/AIDS reports |volume=1 |issue= 1 |pages= 47–53 |year= 2005 |pmid= 16091223 |doi=
*cite journal | author=Kozlowski S, Corr M, Takeshita T, "et al." |title=Serum angiotensin-1 converting enzyme activity processes a human immunodeficiency virus 1 gp160 peptide for presentation by major histocompatibility complex class I molecules. |journal=J. Exp. Med. |volume=175 |issue= 6 |pages= 1417–22 |year= 1992 |pmid= 1316930 |doi=
*cite journal | author=Geraghty DE, Wei XH, Orr HT, Koller BH |title=Human leukocyte antigen F (HLA-F). An expressed HLA gene composed of a class I coding sequence linked to a novel transcribed repetitive element. |journal=J. Exp. Med. |volume=171 |issue= 1 |pages= 1–18 |year= 1990 |pmid= 1688605 |doi=
*cite journal | author=Lury D, Epstein H, Holmes N |title=The human class I MHC gene HLA-F is expressed in lymphocytes. |journal=Int. Immunol. |volume=2 |issue= 6 |pages= 531–7 |year= 1991 |pmid= 1707659 |doi=
*cite journal | author=Takahashi H, Merli S, Putney SD, "et al." |title=A single amino acid interchange yields reciprocal CTL specificities for HIV-1 gp160. |journal=Science |volume=246 |issue= 4926 |pages= 118–21 |year= 1989 |pmid= 2789433 |doi=
*cite journal | author=Dianzani U, Bragardo M, Buonfiglio D, "et al." |title=Modulation of CD4 lateral interaction with lymphocyte surface molecules induced by HIV-1 gp120. |journal=Eur. J. Immunol. |volume=25 |issue= 5 |pages= 1306–11 |year= 1995 |pmid= 7539755 |doi=
*cite journal | author=Howcroft TK, Palmer LA, Brown J, "et al." |title=HIV Tat represses transcription through Sp1-like elements in the basal promoter. |journal=Immunity |volume=3 |issue= 1 |pages= 127–38 |year= 1995 |pmid= 7621073 |doi=
*cite journal | author=Chen YH, Böck G, Vornhagen R, "et al." |title=HIV-1 gp41 enhances major histocompatibility complex class I and ICAM-1 expression on H9 and U937 cells. |journal=Int. Arch. Allergy Immunol. |volume=104 |issue= 3 |pages= 227–31 |year= 1994 |pmid= 7913356 |doi=
*cite journal | author=Chen YH, Böck G, Vornhagen R, "et al." |title=HIV-1 gp41 binding proteins and antibodies to gp41 could inhibit enhancement of human Raji cell MHC class I and II expression by gp41. |journal=Mol. Immunol. |volume=31 |issue= 13 |pages= 977–82 |year= 1994 |pmid= 8084338 |doi=
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=Howcroft TK, Strebel K, Martin MA, Singer DS |title=Repression of MHC class I gene promoter activity by two-exon Tat of HIV. |journal=Science |volume=260 |issue= 5112 |pages= 1320–2 |year= 1993 |pmid= 8493575 |doi=
*cite journal | author=Gasparini P, Borgato L, Piperno A, "et al." |title=Linkage analysis of 6p21 polymorphic markers and the hereditary hemochromatosis: localization of the gene centromeric to HLA-F. |journal=Hum. Mol. Genet. |volume=2 |issue= 5 |pages= 571–6 |year= 1993 |pmid= 8518796 |doi=
*cite journal | author=Schwartz O, Maréchal V, Le Gall S, "et al." |title=Endocytosis of major histocompatibility complex class I molecules is induced by the HIV-1 Nef protein. |journal=Nat. Med. |volume=2 |issue= 3 |pages= 338–42 |year= 1996 |pmid= 8612235 |doi=
*cite journal | author=Alexander-Miller MA, Parker KC, Tsukui T, "et al." |title=Molecular analysis of presentation by HLA-A2.1 of a promiscuously binding V3 loop peptide from the HIV-envelope protein to human cytotoxic T lymphocytes. |journal=Int. Immunol. |volume=8 |issue= 5 |pages= 641–9 |year= 1997 |pmid= 8671651 |doi=

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