- Transportin 1
Transportin 1, also known as TNPO1, is a human
gene .cite web | title = Entrez Gene: TNPO1 transportin 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3842| accessdate = ]PBB_Summary
section_title =
summary_text = This gene encodes the beta subunit of the karyopherin receptor complex which interacts with nuclear localization signals to target nuclear proteins to the nucleus. The karyopherin receptor complex is a heterodimer of an alpha subunit which recognizes the nuclear localization signal and a beta subunit which docks the complex at nucleoporins. Alternate splicing of this gene results in two transcript variants encoding different proteins.cite web | title = Entrez Gene: TNPO1 transportin 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3842| accessdate = ]References
Further reading
PBB_Further_reading
citations =
*cite journal | author=Bukrinsky MI, Haffar OK |title=HIV-1 nuclear import: in search of a leader. |journal=Front. Biosci. |volume=2 |issue= |pages= d578–87 |year= 2004 |pmid= 9366553 |doi=
*cite journal | author=Bukrinsky MI, Haffar OK |title=HIV-1 nuclear import: matrix protein is back on center stage, this time together with Vpr. |journal=Mol. Med. |volume=4 |issue= 3 |pages= 138–43 |year= 1998 |pmid= 9562972 |doi=
*cite journal | author=Bukrinsky MI, Sharova N, Dempsey MP, "et al." |title=Active nuclear import of human immunodeficiency virus type 1 preintegration complexes. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=89 |issue= 14 |pages= 6580–4 |year= 1992 |pmid= 1631159 |doi=
*cite journal | author=Moroianu J, Hijikata M, Blobel G, Radu A |title=Mammalian karyopherin alpha 1 beta and alpha 2 beta heterodimers: alpha 1 or alpha 2 subunit binds nuclear localization signal and beta subunit interacts with peptide repeat-containing nucleoporins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=92 |issue= 14 |pages= 6532–6 |year= 1995 |pmid= 7604027 |doi=
*cite journal | author=Bukrinsky MI, Haggerty S, Dempsey MP, "et al." |title=A nuclear localization signal within HIV-1 matrix protein that governs infection of non-dividing cells. |journal=Nature |volume=365 |issue= 6447 |pages= 666–9 |year= 1993 |pmid= 8105392 |doi= 10.1038/365666a0
*cite journal | author=Michael WM, Choi M, Dreyfuss G |title=A nuclear export signal in hnRNP A1: a signal-mediated, temperature-dependent nuclear protein export pathway. |journal=Cell |volume=83 |issue= 3 |pages= 415–22 |year= 1996 |pmid= 8521471 |doi=
*cite journal | author=Pollard VW, Michael WM, Nakielny S, "et al." |title=A novel receptor-mediated nuclear protein import pathway. |journal=Cell |volume=86 |issue= 6 |pages= 985–94 |year= 1996 |pmid= 8808633 |doi=
*cite journal | author=Nakielny S, Siomi MC, Siomi H, "et al." |title=Transportin: nuclear transport receptor of a novel nuclear protein import pathway. |journal=Exp. Cell Res. |volume=229 |issue= 2 |pages= 261–6 |year= 1997 |pmid= 8986607 |doi= 10.1006/excr.1996.0369
*cite journal | author=Bonifaci N, Moroianu J, Radu A, Blobel G |title=Karyopherin beta2 mediates nuclear import of a mRNA binding protein. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 10 |pages= 5055–60 |year= 1997 |pmid= 9144189 |doi=
*cite journal | author=Fridell RA, Truant R, Thorne L, "et al." |title=Nuclear import of hnRNP A1 is mediated by a novel cellular cofactor related to karyopherin-beta. |journal=J. Cell. Sci. |volume=110 ( Pt 11) |issue= |pages= 1325–31 |year= 1997 |pmid= 9202393 |doi=
*cite journal | author=Gallay P, Hope T, Chin D, Trono D |title=HIV-1 infection of nondividing cells through the recognition of integrase by the importin/karyopherin pathway. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 18 |pages= 9825–30 |year= 1997 |pmid= 9275210 |doi=
*cite journal | author=Siomi MC, Eder PS, Kataoka N, "et al." |title=Transportin-mediated nuclear import of heterogeneous nuclear RNP proteins. |journal=J. Cell Biol. |volume=138 |issue= 6 |pages= 1181–92 |year= 1997 |pmid= 9298975 |doi=
*cite journal | author=Henderson BR, Percipalle P |title=Interactions between HIV Rev and nuclear import and export factors: the Rev nuclear localisation signal mediates specific binding to human importin-beta. |journal=J. Mol. Biol. |volume=274 |issue= 5 |pages= 693–707 |year= 1998 |pmid= 9405152 |doi= 10.1006/jmbi.1997.1420
*cite journal | author=Efthymiadis A, Briggs LJ, Jans DA |title=The HIV-1 Tat nuclear localization sequence confers novel nuclear import properties. |journal=J. Biol. Chem. |volume=273 |issue= 3 |pages= 1623–8 |year= 1998 |pmid= 9430704 |doi=
*cite journal | author=Vodicka MA, Koepp DM, Silver PA, Emerman M |title=HIV-1 Vpr interacts with the nuclear transport pathway to promote macrophage infection. |journal=Genes Dev. |volume=12 |issue= 2 |pages= 175–85 |year= 1998 |pmid= 9436978 |doi=
*cite journal | author=Popov S, Rexach M, Zybarth G, "et al." |title=Viral protein R regulates nuclear import of the HIV-1 pre-integration complex. |journal=EMBO J. |volume=17 |issue= 4 |pages= 909–17 |year= 1998 |pmid= 9463369 |doi= 10.1093/emboj/17.4.909
*cite journal | author=Popov S, Rexach M, Ratner L, "et al." |title=Viral protein R regulates docking of the HIV-1 preintegration complex to the nuclear pore complex. |journal=J. Biol. Chem. |volume=273 |issue= 21 |pages= 13347–52 |year= 1998 |pmid= 9582382 |doi=
*cite journal | author=Fouchier RA, Meyer BE, Simon JH, "et al." |title=Interaction of the human immunodeficiency virus type 1 Vpr protein with the nuclear pore complex. |journal=J. Virol. |volume=72 |issue= 7 |pages= 6004–13 |year= 1998 |pmid= 9621063 |doi=PBB_Controls
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