Actinin alpha 4

Actinin alpha 4

Actinin, alpha 4, also known as ACTN4, is a human gene.cite web | title = Entrez Gene: ACTN4 actinin, alpha 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=81| accessdate = ]

PBB_Summary
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summary_text = Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, alpha actinin isoform which is concentrated in the cytoplasm, and thought to be involved in metastatic processes. Mutations in this gene have been associated with focal and segmental glomerulosclerosis.cite web | title = Entrez Gene: ACTN4 actinin, alpha 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=81| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Dawson SJ, White LA |title=Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin. |journal=J. Infect. |volume=24 |issue= 3 |pages= 317–20 |year= 1992 |pmid= 1602151 |doi=
*cite journal | author=Yürüker B, Niggli V |title=Alpha-actinin and vinculin in human neutrophils: reorganization during adhesion and relation to the actin network. |journal=J. Cell. Sci. |volume=101 ( Pt 2) |issue= |pages= 403–14 |year= 1992 |pmid= 1629252 |doi=
*cite journal | author=Otey CA, Pavalko FM, Burridge K |title=An interaction between alpha-actinin and the beta 1 integrin subunit in vitro. |journal=J. Cell Biol. |volume=111 |issue= 2 |pages= 721–9 |year= 1990 |pmid= 2116421 |doi=
*cite journal | author=Pavalko FM, LaRoche SM |title=Activation of human neutrophils induces an interaction between the integrin beta 2-subunit (CD18) and the actin binding protein alpha-actinin. |journal=J. Immunol. |volume=151 |issue= 7 |pages= 3795–807 |year= 1993 |pmid= 8104223 |doi=
*cite journal | author=Mathis BJ, Kim SH, Calabrese K, "et al." |title=A locus for inherited focal segmental glomerulosclerosis maps to chromosome 19q13. |journal=Kidney Int. |volume=53 |issue= 2 |pages= 282–6 |year= 1998 |pmid= 9461087 |doi= 10.1046/j.1523-1755.1998.00828.x
*cite journal | author=Honda K, Yamada T, Endo R, "et al." |title=Actinin-4, a novel actin-bundling protein associated with cell motility and cancer invasion. |journal=J. Cell Biol. |volume=140 |issue= 6 |pages= 1383–93 |year= 1998 |pmid= 9508771 |doi=
*cite journal | author=Zhang H, Wang L, Kao S, "et al." |title=Functional interaction between the cytoplasmic leucine-zipper domain of HIV-1 gp41 and p115-RhoGEF. |journal=Curr. Biol. |volume=9 |issue= 21 |pages= 1271–4 |year= 1999 |pmid= 10556093 |doi=
*cite journal | author=Nikolopoulos SN, Spengler BA, Kisselbach K, "et al." |title=The human non-muscle alpha-actinin protein encoded by the ACTN4 gene suppresses tumorigenicity of human neuroblastoma cells. |journal=Oncogene |volume=19 |issue= 3 |pages= 380–6 |year= 2000 |pmid= 10656685 |doi= 10.1038/sj.onc.1203310
*cite journal | author=El-Husseini AE, Kwasnicka D, Yamada T, "et al." |title=BERP, a novel ring finger protein, binds to alpha-actinin-4. |journal=Biochem. Biophys. Res. Commun. |volume=267 |issue= 3 |pages= 906–11 |year= 2000 |pmid= 10673389 |doi= 10.1006/bbrc.1999.2045
*cite journal | author=Kaplan JM, Kim SH, North KN, "et al." |title=Mutations in ACTN4, encoding alpha-actinin-4, cause familial focal segmental glomerulosclerosis. |journal=Nat. Genet. |volume=24 |issue= 3 |pages= 251–6 |year= 2000 |pmid= 10700177 |doi= 10.1038/73456
*cite journal | author=Vallenius T, Luukko K, Mäkelä TP |title=CLP-36 PDZ-LIM protein associates with nonmuscle alpha-actinin-1 and alpha-actinin-4. |journal=J. Biol. Chem. |volume=275 |issue= 15 |pages= 11100–5 |year= 2000 |pmid= 10753915 |doi=
*cite journal | author=Holliday LS, Lu M, Lee BS, "et al." |title=The amino-terminal domain of the B subunit of vacuolar H+-ATPase contains a filamentous actin binding site. |journal=J. Biol. Chem. |volume=275 |issue= 41 |pages= 32331–7 |year= 2000 |pmid= 10915794 |doi= 10.1074/jbc.M004795200
*cite journal | author=Walikonis RS, Oguni A, Khorosheva EM, "et al." |title=Densin-180 forms a ternary complex with the (alpha)-subunit of Ca2+/calmodulin-dependent protein kinase II and (alpha)-actinin. |journal=J. Neurosci. |volume=21 |issue= 2 |pages= 423–33 |year= 2001 |pmid= 11160423 |doi=
*cite journal | author=Echchakir H, Mami-Chouaib F, Vergnon I, "et al." |title=A point mutation in the alpha-actinin-4 gene generates an antigenic peptide recognized by autologous cytolytic T lymphocytes on a human lung carcinoma. |journal=Cancer Res. |volume=61 |issue= 10 |pages= 4078–83 |year= 2001 |pmid= 11358829 |doi=
*cite journal | author=Xu F, Zhao R, Peng Y, "et al." |title=Association of tyrosine phosphatase SHP-2 with F-actin at low cell densities. |journal=J. Biol. Chem. |volume=276 |issue= 31 |pages= 29479–84 |year= 2001 |pmid= 11382784 |doi= 10.1074/jbc.M104428200
*cite journal | author=Hüttelmaier S, Illenberger S, Grosheva I, "et al." |title=Raver1, a dual compartment protein, is a ligand for PTB/hnRNPI and microfilament attachment proteins. |journal=J. Cell Biol. |volume=155 |issue= 5 |pages= 775–86 |year= 2002 |pmid= 11724819 |doi= 10.1083/jcb.200105044
*cite journal | author=Renoult C, Blondin L, Fattoum A, "et al." |title=Binding of gelsolin domain 2 to actin. An actin interface distinct from that of gelsolin domain 1 and from ADF/cofilin. |journal=Eur. J. Biochem. |volume=268 |issue= 23 |pages= 6165–75 |year= 2002 |pmid= 11733011 |doi=
*cite journal | author=Gonzalez AM, Otey C, Edlund M, Jones JC |title=Interactions of a hemidesmosome component and actinin family members. |journal=J. Cell. Sci. |volume=114 |issue= Pt 23 |pages= 4197–206 |year= 2002 |pmid= 11739652 |doi=
*cite journal | author=Lukoyanova N, VanLoock MS, Orlova A, "et al." |title=Each actin subunit has three nebulin binding sites: implications for steric blocking. |journal=Curr. Biol. |volume=12 |issue= 5 |pages= 383–8 |year= 2002 |pmid= 11882289 |doi=
*cite journal | author=Kim JH, Lee-Kwon W, Park JB, "et al." |title=Ca(2+)-dependent inhibition of Na+/H+ exchanger 3 (NHE3) requires an NHE3-E3KARP-alpha-actinin-4 complex for oligomerization and endocytosis. |journal=J. Biol. Chem. |volume=277 |issue= 26 |pages= 23714–24 |year= 2002 |pmid= 11948184 |doi= 10.1074/jbc.M200835200

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