Interleukin 1 receptor, type I

Interleukin 1 receptor, type I (IL1R1) also known as CD121a (Cluster of Differentiation 121a), is an interleukin receptor. IL1R1 also denotes its human gene.cite web | title = Entrez Gene: IL1R1 interleukin 1 receptor, type I| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3554| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene is a cytokine receptor that belongs to the interleukin-1 receptor family. This protein is a receptor for interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I(IL1R1/IL1RA). It is an important mediator involved in many cytokine induced immune and inflammatory responses. This gene along with interleukin 1 receptor, type II (IL1R2), interleukin 1 receptor-like 2 (IL1RL2), and interleukin 1 receptor-like 1 (IL1RL1) form a cytokine receptor gene cluster in a region mapped to chromosome 2q12.cite web | title = Entrez Gene: IL1R1 interleukin 1 receptor, type I| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3554| accessdate = ]

ee also

* Cluster of differentiation
* Interleukin 1 receptor, type II

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Copeland NG, Silan CM, Kingsley DM, "et al." |title=Chromosomal location of murine and human IL-1 receptor genes. |journal=Genomics |volume=9 |issue= 1 |pages= 44–50 |year= 1991 |pmid= 1672292 |doi=
*cite journal | author=McMahan CJ, Slack JL, Mosley B, "et al." |title=A novel IL-1 receptor, cloned from B cells by mammalian expression, is expressed in many cell types. |journal=EMBO J. |volume=10 |issue= 10 |pages= 2821–32 |year= 1991 |pmid= 1833184 |doi=
*cite journal | author=Uhl J, Newton RC, Giri JG, "et al." |title=Identification of IL-1 receptors on human monocytes. |journal=J. Immunol. |volume=142 |issue= 5 |pages= 1576–81 |year= 1989 |pmid= 2521881 |doi=
*cite journal | author=Sims JE, Acres RB, Grubin CE, "et al." |title=Cloning the interleukin 1 receptor from human T cells. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=86 |issue= 22 |pages= 8946–50 |year= 1989 |pmid= 2530587 |doi=
*cite journal | author=Chua AO, Gubler U |title=Sequence of the cDNA for the human fibroblast type interleukin-1 receptor. |journal=Nucleic Acids Res. |volume=17 |issue= 23 |pages= 10114 |year= 1990 |pmid= 2532321 |doi=
*cite journal | author=Dower SK, Kronheim SR, Hopp TP, "et al." |title=The cell surface receptors for interleukin-1 alpha and interleukin-1 beta are identical. |journal=Nature |volume=324 |issue= 6094 |pages= 266–8 |year= 1987 |pmid= 2946959 |doi= 10.1038/324266a0
*cite journal | author=Rautonen N, Rautonen J, Martin NL, Wara DW |title=HIV-1 Tat induces cytokine synthesis by uninfected mononuclear cells. |journal=AIDS |volume=8 |issue= 10 |pages= 1504–6 |year= 1995 |pmid= 7818827 |doi=
*cite journal | author=Vigers GP, Anderson LJ, Caffes P, Brandhuber BJ |title=Crystal structure of the type-I interleukin-1 receptor complexed with interleukin-1beta. |journal=Nature |volume=386 |issue= 6621 |pages= 190–4 |year= 1997 |pmid= 9062193 |doi= 10.1038/386190a0
*cite journal | author=Schreuder H, Tardif C, Trump-Kallmeyer S, "et al." |title=A new cytokine-receptor binding mode revealed by the crystal structure of the IL-1 receptor with an antagonist. |journal=Nature |volume=386 |issue= 6621 |pages= 194–200 |year= 1997 |pmid= 9062194 |doi= 10.1038/386194a0
*cite journal | author=Rameshwar P, Poddar A, Zhu G, Gascón P |title=Receptor induction regulates the synergistic effects of substance P with IL-1 and platelet-derived growth factor on the proliferation of bone marrow fibroblasts. |journal=J. Immunol. |volume=158 |issue= 7 |pages= 3417–24 |year= 1997 |pmid= 9120302 |doi=
*cite journal | author=Reddy SA, Huang JH, Liao WS |title=Phosphatidylinositol 3-kinase in interleukin 1 signaling. Physical interaction with the interleukin 1 receptor and requirement in NFkappaB and AP-1 activation. |journal=J. Biol. Chem. |volume=272 |issue= 46 |pages= 29167–73 |year= 1997 |pmid= 9360994 |doi=
*cite journal | author=Huang J, Gao X, Li S, Cao Z |title=Recruitment of IRAK to the interleukin 1 receptor complex requires interleukin 1 receptor accessory protein. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 24 |pages= 12829–32 |year= 1998 |pmid= 9371760 |doi=
*cite journal | author=Muzio M, Ni J, Feng P, Dixit VM |title=IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling. |journal=Science |volume=278 |issue= 5343 |pages= 1612–5 |year= 1997 |pmid= 9374458 |doi=
*cite journal | author=Dale M, Nicklin MJ |title=Interleukin-1 receptor cluster: gene organization of IL1R2, IL1R1, IL1RL2 (IL-1Rrp2), IL1RL1 (T1/ST2), and IL18R1 (IL-1Rrp) on human chromosome 2q. |journal=Genomics |volume=57 |issue= 1 |pages= 177–9 |year= 1999 |pmid= 10191101 |doi= 10.1006/geno.1999.5767
*cite journal | author=Sizemore N, Leung S, Stark GR |title=Activation of phosphatidylinositol 3-kinase in response to interleukin-1 leads to phosphorylation and activation of the NF-kappaB p65/RelA subunit. |journal=Mol. Cell. Biol. |volume=19 |issue= 7 |pages= 4798–805 |year= 1999 |pmid= 10373529 |doi=
*cite journal | author=Burns K, Clatworthy J, Martin L, "et al." |title=Tollip, a new component of the IL-1RI pathway, links IRAK to the IL-1 receptor. |journal=Nat. Cell Biol. |volume=2 |issue= 6 |pages= 346–51 |year= 2000 |pmid= 10854325 |doi= 10.1038/35014038
*cite journal | author=Vigers GP, Dripps DJ, Edwards CK, Brandhuber BJ |title=X-ray crystal structure of a small antagonist peptide bound to interleukin-1 receptor type 1. |journal=J. Biol. Chem. |volume=275 |issue= 47 |pages= 36927–33 |year= 2001 |pmid= 10903327 |doi= 10.1074/jbc.M006071200
*cite journal | author=Lin H, Ho AS, Haley-Vicente D, "et al." |title=Cloning and characterization of IL-1HY2, a novel interleukin-1 family member. |journal=J. Biol. Chem. |volume=276 |issue= 23 |pages= 20597–602 |year= 2001 |pmid= 11278614 |doi= 10.1074/jbc.M010095200
*cite journal | author=Joos L, McIntyre L, Ruan J, "et al." |title=Association of IL-1beta and IL-1 receptor antagonist haplotypes with rate of decline in lung function in smokers. |journal=Thorax |volume=56 |issue= 11 |pages= 863–6 |year= 2001 |pmid= 11641511 |doi=
*cite journal | author=Köller M, Kutscha-Lissberg F, Brom J, "et al." |title=Influence of low molecular weight heparin (certoparin) and unfractionated heparin on the release of cytokines from human leukocytes. |journal=Inflammation |volume=25 |issue= 5 |pages= 331–7 |year= 2003 |pmid= 11820460 |doi=

External links

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