- ATP2B4
ATPase, Ca++ transporting, plasma membrane 4, also known as ATP2B4, is a human
gene .cite web | title = Entrez Gene: ATP2B4 ATPase, Ca++ transporting, plasma membrane 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=493| accessdate = ]PBB_Summary
section_title =
summary_text = The protein encoded by this gene belongs to the family of P-type primary ion transport ATPases characterized by the formation of an aspartyl phosphate intermediate during the reaction cycle. These enzymes remove bivalent calcium ions from eukaryotic cells against very large concentration gradients and play a critical role in intracellular calcium homeostasis. The mammalian plasma membrane calcium ATPase isoforms are encoded by at least four separate genes and the diversity of these enzymes is further increased by alternative splicing of transcripts. The expression of different isoforms and splice variants is regulated in a developmental, tissue- and cell type-specific manner, suggesting that these pumps are functionally adapted to the physiological needs of particular cells and tissues. This gene encodes the plasma membrane calcium ATPase isoform 4. Alternatively spliced transcript variants encoding different isoforms have been identified.cite web | title = Entrez Gene: ATP2B4 ATPase, Ca++ transporting, plasma membrane 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=493| accessdate = ]References
Further reading
PBB_Further_reading
citations =
*cite journal | author=Møller JV, Juul B, le Maire M |title=Structural organization, ion transport, and energy transduction of P-type ATPases. |journal=Biochim. Biophys. Acta |volume=1286 |issue= 1 |pages= 1–51 |year= 1996 |pmid= 8634322 |doi=
*cite journal | author=Strehler EE, Zacharias DA |title=Role of alternative splicing in generating isoform diversity among plasma membrane calcium pumps. |journal=Physiol. Rev. |volume=81 |issue= 1 |pages= 21–50 |year= 2001 |pmid= 11152753 |doi=
*cite journal | author=Strehler EE, Treiman M |title=Calcium pumps of plasma membrane and cell interior. |journal=Curr. Mol. Med. |volume=4 |issue= 3 |pages= 323–35 |year= 2004 |pmid= 15101689 |doi=
*cite journal | author=Heim R, Hug M, Iwata T, "et al." |title=Microdiversity of human-plasma-membrane calcium-pump isoform 2 generated by alternative RNA splicing in the N-terminal coding region. |journal=Eur. J. Biochem. |volume=205 |issue= 1 |pages= 333–40 |year= 1992 |pmid= 1313367 |doi=
*cite journal | author=Brandt P, Neve RL, Kammesheidt A, "et al." |title=Analysis of the tissue-specific distribution of mRNAs encoding the plasma membrane calcium-pumping ATPases and characterization of an alternately spliced form of PMCA4 at the cDNA and genomic levels. |journal=J. Biol. Chem. |volume=267 |issue= 7 |pages= 4376–85 |year= 1992 |pmid= 1531651 |doi=
*cite journal | author=Olson S, Wang MG, Carafoli E, "et al." |title=Localization of two genes encoding plasma membrane Ca2(+)-transporting ATPases to human chromosomes 1q25-32 and 12q21-23. |journal=Genomics |volume=9 |issue= 4 |pages= 629–41 |year= 1991 |pmid= 1674727 |doi=
*cite journal | author=Strehler EE, James P, Fischer R, "et al." |title=Peptide sequence analysis and molecular cloning reveal two calcium pump isoforms in the human erythrocyte membrane. |journal=J. Biol. Chem. |volume=265 |issue= 5 |pages= 2835–42 |year= 1990 |pmid= 2137451 |doi=
*cite journal | author=James P, Maeda M, Fischer R, "et al." |title=Identification and primary structure of a calmodulin binding domain of the Ca2+ pump of human erythrocytes. |journal=J. Biol. Chem. |volume=263 |issue= 6 |pages= 2905–10 |year= 1988 |pmid= 2963820 |doi=
*cite journal | author=Brandt P, Zurini M, Neve RL, "et al." |title=A C-terminal, calmodulin-like regulatory domain from the plasma membrane Ca2+-pumping ATPase. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=85 |issue= 9 |pages= 2914–8 |year= 1988 |pmid= 2966397 |doi=
*cite journal | author=Howard A, Barley NF, Legon S, Walters JR |title=Plasma-membrane calcium-pump isoforms in human and rat liver. |journal=Biochem. J. |volume=303 ( Pt 1) |issue= |pages= 275–9 |year= 1994 |pmid= 7945253 |doi=
*cite journal | author=Stauffer TP, Hilfiker H, Carafoli E, Strehler EE |title=Quantitative analysis of alternative splicing options of human plasma membrane calcium pump genes. |journal=J. Biol. Chem. |volume=269 |issue= 50 |pages= 32022 |year= 1995 |pmid= 7989379 |doi=
*cite journal | author=Stauffer TP, Hilfiker H, Carafoli E, Strehler EE |title=Quantitative analysis of alternative splicing options of human plasma membrane calcium pump genes. |journal=J. Biol. Chem. |volume=268 |issue= 34 |pages= 25993–6003 |year= 1994 |pmid= 8245032 |doi=
*cite journal | author=Váradi A, Molnár E, Ashcroft SJ |title=A unique combination of plasma membrane Ca2+-ATPase isoforms is expressed in islets of Langerhans and pancreatic beta-cell lines. |journal=Biochem. J. |volume=314 ( Pt 2) |issue= |pages= 663–9 |year= 1996 |pmid= 8670083 |doi=
*cite journal | author=Santiago-García J, Mas-Oliva J, Saavedra D, Zarain-Herzberg A |title=Analysis of mRNA expression and cloning of a novel plasma membrane Ca(2+)-ATPase splice variant in human heart. |journal=Mol. Cell. Biochem. |volume=155 |issue= 2 |pages= 173–82 |year= 1996 |pmid= 8700162 |doi=
*cite journal | author=Zacharias DA, DeMarco SJ, Strehler EE |title=mRNA expression of the four isoforms of the human plasma membrane Ca(2+)-ATPase in the human hippocampus. |journal=Brain Res. Mol. Brain Res. |volume=45 |issue= 1 |pages= 173–6 |year= 1997 |pmid= 9105688 |doi=
*cite journal | author=Dean WL, Chen D, Brandt PC, Vanaman TC |title=Regulation of platelet plasma membrane Ca2+-ATPase by cAMP-dependent and tyrosine phosphorylation. |journal=J. Biol. Chem. |volume=272 |issue= 24 |pages= 15113–9 |year= 1997 |pmid= 9182531 |doi=
*cite journal | author=Kim E, DeMarco SJ, Marfatia SM, "et al." |title=Plasma membrane Ca2+ ATPase isoform 4b binds to membrane-associated guanylate kinase (MAGUK) proteins via their PDZ (PSD-95/Dlg/ZO-1) domains. |journal=J. Biol. Chem. |volume=273 |issue= 3 |pages= 1591–5 |year= 1998 |pmid= 9430700 |doi=
*cite journal | author=Guerini D, García-Martin E, Gerber A, "et al." |title=The expression of plasma membrane Ca2+ pump isoforms in cerebellar granule neurons is modulated by Ca2+. |journal=J. Biol. Chem. |volume=274 |issue= 3 |pages= 1667–76 |year= 1999 |pmid= 9880546 |doi=
*cite journal | author=Rosado JA, Sage SO |title=Regulation of plasma membrane Ca2+-ATPase by small GTPases and phosphoinositides in human platelets. |journal=J. Biol. Chem. |volume=275 |issue= 26 |pages= 19529–35 |year= 2000 |pmid= 10748016 |doi= 10.1074/jbc.M001319200PBB_Controls
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