Rac2

Rac2

Rac2 (Ras-related C3 botulinum toxin substrate 2) is a small (~21 kDa) signaling G protein (more specifically a GTPase), and is a member of the Rac subfamily of the family Rho family of GTPases.cite journal |author=Ridley A. |year=2006 |title=Rho GTPases and actin dynamics in membrane protrusions and vesicle trafficking |journal=Trends Cell Biol |volume=16 |issue=10 |pages=522–9 |issn=0962-8924 |doi=10.1016/j.tcb.2006.08.006] It is encoded by the gene RAC2.cite web | title = Entrez Gene: RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5880| accessdate = ]

Members of Rho family of GTPases appear to regulate a diverse array of cellular events, including the control of cell growth, cytoskeletal reorganization, and the activation of protein kinases.cite web | title = Entrez Gene: RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5880| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Mizuno T, Kaibuchi K, Ando S, "et al." |title=Regulation of the superoxide-generating NADPH oxidase by a small GTP-binding protein and its stimulatory and inhibitory GDP/GTP exchange proteins. |journal=J. Biol. Chem. |volume=267 |issue= 15 |pages= 10215–8 |year= 1992 |pmid= 1316893 |doi=
*cite journal | author=Reibel L, Dorseuil O, Stancou R, "et al." |title=A hemopoietic specific gene encoding a small GTP binding protein is overexpressed during T cell activation. |journal=Biochem. Biophys. Res. Commun. |volume=175 |issue= 2 |pages= 451–8 |year= 1991 |pmid= 1902092 |doi=
*cite journal | author=Kinsella BT, Erdman RA, Maltese WA |title=Carboxyl-terminal isoprenylation of ras-related GTP-binding proteins encoded by rac1, rac2, and ralA. |journal=J. Biol. Chem. |volume=266 |issue= 15 |pages= 9786–94 |year= 1991 |pmid= 1903399 |doi=
*cite journal | author=Didsbury J, Weber RF, Bokoch GM, "et al." |title=rac, a novel ras-related family of proteins that are botulinum toxin substrates. |journal=J. Biol. Chem. |volume=264 |issue= 28 |pages= 16378–82 |year= 1989 |pmid= 2674130 |doi=
*cite journal | author=Kwong CH, Malech HL, Rotrosen D, Leto TL |title=Regulation of the human neutrophil NADPH oxidase by rho-related G-proteins. |journal=Biochemistry |volume=32 |issue= 21 |pages= 5711–7 |year= 1993 |pmid= 8504089 |doi=
*cite journal | author=Courjal F, Chuchana P, Theillet C, Fort P |title=Structure and chromosomal assignment to 22q12 and 17qter of the ras-related Rac2 and Rac3 human genes. |journal=Genomics |volume=44 |issue= 2 |pages= 242–6 |year= 1997 |pmid= 9299243 |doi= 10.1006/geno.1997.4871
*cite journal | author=Gorvel JP, Chang TC, Boretto J, "et al." |title=Differential properties of D4/LyGDI versus RhoGDI: phosphorylation and rho GTPase selectivity. |journal=FEBS Lett. |volume=422 |issue= 2 |pages= 269–73 |year= 1998 |pmid= 9490022 |doi=
*cite journal | author=Dai Q, Choy E, Chiu V, "et al." |title=Mammalian prenylcysteine carboxyl methyltransferase is in the endoplasmic reticulum. |journal=J. Biol. Chem. |volume=273 |issue= 24 |pages= 15030–4 |year= 1998 |pmid= 9614111 |doi=
*cite journal | author=Ahmed S, Prigmore E, Govind S, "et al." |title=Cryptic Rac-binding and p21(Cdc42Hs/Rac)-activated kinase phosphorylation sites of NADPH oxidase component p67(phox). |journal=J. Biol. Chem. |volume=273 |issue= 25 |pages= 15693–701 |year= 1998 |pmid= 9624165 |doi=
*cite journal | author=Faris SL, Rinckel LA, Huang J, "et al." |title=Phagocyte NADPH oxidase p67-phox possesses a novel carboxylterminal binding site for the GTPases Rac2 and Cdc42. |journal=Biochem. Biophys. Res. Commun. |volume=247 |issue= 2 |pages= 271–6 |year= 1998 |pmid= 9642115 |doi= 10.1006/bbrc.1998.8775
*cite journal | author=Zhang B, Zheng Y |title=Negative regulation of Rho family GTPases Cdc42 and Rac2 by homodimer formation. |journal=J. Biol. Chem. |volume=273 |issue= 40 |pages= 25728–33 |year= 1998 |pmid= 9748241 |doi=
*cite journal | author=Nishihara H, Kobayashi S, Hashimoto Y, "et al." |title=Non-adherent cell-specific expression of DOCK2, a member of the human CDM-family proteins. |journal=Biochim. Biophys. Acta |volume=1452 |issue= 2 |pages= 179–87 |year= 1999 |pmid= 10559471 |doi=
*cite journal | author=Dunham I, Shimizu N, Roe BA, "et al." |title=The DNA sequence of human chromosome 22. |journal=Nature |volume=402 |issue= 6761 |pages= 489–95 |year= 1999 |pmid= 10591208 |doi= 10.1038/990031
*cite journal | author=Scheffzek K, Stephan I, Jensen ON, "et al." |title=The Rac-RhoGDI complex and the structural basis for the regulation of Rho proteins by RhoGDI. |journal=Nat. Struct. Biol. |volume=7 |issue= 2 |pages= 122–6 |year= 2000 |pmid= 10655614 |doi= 10.1038/72392
*cite journal | author=Ambruso DR, Knall C, Abell AN, "et al." |title=Human neutrophil immunodeficiency syndrome is associated with an inhibitory Rac2 mutation. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 9 |pages= 4654–9 |year= 2000 |pmid= 10758162 |doi= 10.1073/pnas.080074897
*cite journal | author=Williams DA, Tao W, Yang F, "et al." |title=Dominant negative mutation of the hematopoietic-specific Rho GTPase, Rac2, is associated with a human phagocyte immunodeficiency. |journal=Blood |volume=96 |issue= 5 |pages= 1646–54 |year= 2000 |pmid= 10961859 |doi=
*cite journal | author=Tamura M, Kai T, Tsunawaki S, "et al." |title=Direct interaction of actin with p47(phox) of neutrophil NADPH oxidase. |journal=Biochem. Biophys. Res. Commun. |volume=276 |issue= 3 |pages= 1186–90 |year= 2000 |pmid= 11027608 |doi= 10.1006/bbrc.2000.3598
*cite journal | author=Zhang QH, Ye M, Wu XY, "et al." |title=Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. |journal=Genome Res. |volume=10 |issue= 10 |pages= 1546–60 |year= 2001 |pmid= 11042152 |doi=
*cite journal | author=Lapouge K, Smith SJ, Walker PA, "et al." |title=Structure of the TPR domain of p67phox in complex with Rac.GTP. |journal=Mol. Cell |volume=6 |issue= 4 |pages= 899–907 |year= 2000 |pmid= 11090627 |doi=
*cite journal | author=Tarricone C, Xiao B, Justin N, "et al." |title=The structural basis of Arfaptin-mediated cross-talk between Rac and Arf signalling pathways. |journal=Nature |volume=411 |issue= 6834 |pages= 215–9 |year= 2001 |pmid= 11346801 |doi= 10.1038/35075620

PBB_Controls
update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = no
update_citations = yes


Wikimedia Foundation. 2010.

Игры ⚽ Нужна курсовая?

Look at other dictionaries:

  • Rac2 — (Ras related C3 botulinum toxin substrate 2) Обозначения Символы Rac2; EN 7 Entrez Gene …   Википедия

  • Rac — Rȁc2, Koloman (1863 1937) DEFINICIJA hrv. klasični filolog i vrstan prevodilac antičkih autora (Antologija stare lirike grčke) …   Hrvatski jezični portal

  • Septische Granulomatose — Klassifikation nach ICD 10 D71 Funktionelle Störungen der neutrophilen Granulozyten Angeborene Dysphagozytose Chronische Granulomatose (im Kindesalter) Defekt des Membranrezeptorenkomplexes (CR3) Progressive septische Granulomatose …   Deutsch Wikipedia

  • NADPH-оксидаза — У этого термина существуют и другие значения, см. Nox. Химическая формула NADPH НАДФ•H оксидаза, или NADPH оксидаза (NOX)  клеточный …   Википедия

  • NADPH oxidase — NADP+ The NADPH oxidase (nicotinamide adenine dinucleotide phosphate oxidase) is a membrane bound enzyme complex. It can be found in the plasma membrane as well as in the membrane of phagosome. Contents 1 …   Wikipedia

  • Dock2 — Dedicator of cytokinesis 2 Rendering based on PDB 2RQR …   Wikipedia

  • Neutrophil immunodeficiency syndrome — Classification and external resources OMIM 608203 Neutrophil immunodeficiency syndrome is a condition caused by mutations in the Rac2 gene.[1] See also …   Wikipedia

  • Ras (protein) — Pfam box Symbol = Ras Name = width =250 caption = Triphosphate Structure of H Ras p21 GNBP in complex with GppNHp and Mg2+ (PDB Code 5p21). Important sequence elements are highlighted. Pfam= PF00071 InterPro= IPR013753 SMART= PROSITE = PDOC00859… …   Wikipedia

  • Noonan syndrome — Classification and external resources A 12 year old female with Noonan syndrome. Typical webbed neck. Double structural curve with rib deformity. ICD 10 Q …   Wikipedia

  • Inorganic compounds by element — This page aims to list concisely all of the common inorganic and organometallic compounds of each element, whether or not they have an existing page. These are compounds that may warrant their own individual pages. Compounds are listed… …   Wikipedia

Share the article and excerpts

Direct link
… Do a right-click on the link above
and select “Copy Link”