DKK1


DKK1
Dickkopf homolog 1 (Xenopus laevis)
Identifiers
Symbols DKK1; DKK-1; SK
External IDs OMIM605189 MGI1329040 HomoloGene7689 GeneCards: DKK1 Gene
RNA expression pattern
PBB GE DKK1 204602 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 22943 13380
Ensembl ENSG00000107984 ENSMUSG00000024868
UniProt O94907 Q80UL5
RefSeq (mRNA) NM_012242 NM_010051.3
RefSeq (protein) NP_036374 NP_034181.2
Location (UCSC) Chr 10:
54.07 – 54.08 Mb
Chr 19:
30.62 – 30.62 Mb
PubMed search [1] [2]

Dickkopf-related protein 1 is a protein that in humans is encoded by the DKK1 gene.[1]

This gene encodes a protein that is a member of the dickkopf family. It is a secreted protein with two cysteine rich regions and is involved in embryonic development through its inhibition of the WNT signaling pathway. Elevated levels of DKK1 in bone marrow plasma and peripheral blood is associated with the presence of osteolytic bone lesions in patients with multiple myeloma.[1]

Interactions

DKK1 has been shown to interact with LRP6.[2]

References

  1. ^ a b "Entrez Gene: DKK1 dickkopf homolog 1 (Xenopus laevis)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=22943. 
  2. ^ Semënov, M V; Tamai K, Brott B K, Kühl M, Sokol S, He X (Jun. 2001). "Head inducer Dickkopf-1 is a ligand for Wnt coreceptor LRP6". Curr. Biol. (England) 11 (12): 951–61. doi:10.1016/S0960-9822(01)00290-1. ISSN 0960-9822. PMID 11448771. 

Further reading


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