Peroxiredoxin 1

Peroxiredoxin 1, also known as PRDX1, is a human gene.cite web | title = Entrez Gene: PRDX1 peroxiredoxin 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5052| accessdate = ]

PBB_Summary
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summary_text = This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein may play an antioxidant protective role in cells, and may contribute to the antiviral activity of CD8(+) T-cells. This protein may have a proliferative effect and play a role in cancer development or progression. Three transcript variants encoding the same protein have been identified for this gene.cite web | title = Entrez Gene: PRDX1 peroxiredoxin 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5052| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Wood ZA, Schröder E, Robin Harris J, Poole LB |title=Structure, mechanism and regulation of peroxiredoxins. |journal=Trends Biochem. Sci. |volume=28 |issue= 1 |pages= 32–40 |year= 2003 |pmid= 12517450 |doi=
*cite journal | author=Sauri H, Butterfield L, Kim A, Shau H |title=Antioxidant function of recombinant human natural killer enhancing factor. |journal=Biochem. Biophys. Res. Commun. |volume=208 |issue= 3 |pages= 964–9 |year= 1995 |pmid= 7702627 |doi=
*cite journal | author=Shau H, Butterfield LH, Chiu R, Kim A |title=Cloning and sequence analysis of candidate human natural killer-enhancing factor genes. |journal=Immunogenetics |volume=40 |issue= 2 |pages= 129–34 |year= 1994 |pmid= 8026862 |doi=
*cite journal | author=Kawai S, Takeshita S, Okazaki M, "et al." |title=Cloning and characterization of OSF-3, a new member of the MER5 family, expressed in mouse osteoblastic cells. |journal=J. Biochem. |volume=115 |issue= 4 |pages= 641–3 |year= 1994 |pmid= 8089076 |doi=
*cite journal | author=Shau H, Kim A |title=Identification of natural killer enhancing factor as a major antioxidant in human red blood cells. |journal=Biochem. Biophys. Res. Commun. |volume=199 |issue= 1 |pages= 83–8 |year= 1994 |pmid= 8123050 |doi=
*cite journal | author=Prospéri MT, Apiou F, Dutrillaux B, Goubin G |title=Organization and chromosomal assignment of two human PAG gene loci: PAGA encoding a functional gene and PAGB a processed pseudogene. |journal=Genomics |volume=19 |issue= 2 |pages= 236–41 |year= 1994 |pmid= 8188254 |doi= 10.1006/geno.1994.1053
*cite journal | author=Prospéri MT, Ferbus D, Karczinski I, Goubin G |title=A human cDNA corresponding to a gene overexpressed during cell proliferation encodes a product sharing homology with amoebic and bacterial proteins. |journal=J. Biol. Chem. |volume=268 |issue= 15 |pages= 11050–6 |year= 1993 |pmid= 8496166 |doi=
*cite journal | author=Wen ST, Van Etten RA |title=The PAG gene product, a stress-induced protein with antioxidant properties, is an Abl SH3-binding protein and a physiological inhibitor of c-Abl tyrosine kinase activity. |journal=Genes Dev. |volume=11 |issue= 19 |pages= 2456–67 |year= 1997 |pmid= 9334312 |doi=
*cite journal | author=Jin DY, Chae HZ, Rhee SG, Jeang KT |title=Regulatory role for a novel human thioredoxin peroxidase in NF-kappaB activation. |journal=J. Biol. Chem. |volume=272 |issue= 49 |pages= 30952–61 |year= 1998 |pmid= 9388242 |doi=
*cite journal | author=Outinen PA, Sood SK, Pfeifer SI, "et al." |title=Homocysteine-induced endoplasmic reticulum stress and growth arrest leads to specific changes in gene expression in human vascular endothelial cells. |journal=Blood |volume=94 |issue= 3 |pages= 959–67 |year= 1999 |pmid= 10419887 |doi=
*cite journal | author=Yanagawa T, Ishikawa T, Ishii T, "et al." |title=Peroxiredoxin I expression in human thyroid tumors. |journal=Cancer Lett. |volume=145 |issue= 1-2 |pages= 127–32 |year= 1999 |pmid= 10530780 |doi=
*cite journal | author=Noh DY, Ahn SJ, Lee RA, "et al." |title=Overexpression of peroxiredoxin in human breast cancer. |journal=Anticancer Res. |volume=21 |issue= 3B |pages= 2085–90 |year= 2001 |pmid= 11497302 |doi=
*cite journal | author=Xu XR, Huang J, Xu ZG, "et al." |title=Insight into hepatocellular carcinogenesis at transcriptome level by comparing gene expression profiles of hepatocellular carcinoma with those of corresponding noncancerous liver. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 26 |pages= 15089–94 |year= 2002 |pmid= 11752456 |doi= 10.1073/pnas.241522398
*cite journal | author=Kim SH, Fountoulakis M, Cairns N, Lubec G |title=Protein levels of human peroxiredoxin subtypes in brains of patients with Alzheimer's disease and Down syndrome. |journal=J. Neural Transm. Suppl. |volume= |issue= 61 |pages= 223–35 |year= 2002 |pmid= 11771746 |doi=
*cite journal | author=Rabilloud T, Heller M, Gasnier F, "et al." |title=Proteomics analysis of cellular response to oxidative stress. Evidence for in vivo overoxidation of peroxiredoxins at their active site. |journal=J. Biol. Chem. |volume=277 |issue= 22 |pages= 19396–401 |year= 2002 |pmid= 11904290 |doi= 10.1074/jbc.M106585200
*cite journal | author=Chang TS, Jeong W, Choi SY, "et al." |title=Regulation of peroxiredoxin I activity by Cdc2-mediated phosphorylation. |journal=J. Biol. Chem. |volume=277 |issue= 28 |pages= 25370–6 |year= 2002 |pmid= 11986303 |doi= 10.1074/jbc.M110432200
*cite journal | author=Wagner E, Luche S, Penna L, "et al." |title=A method for detection of overoxidation of cysteines: peroxiredoxins are oxidized in vivo at the active-site cysteine during oxidative stress. |journal=Biochem. J. |volume=366 |issue= Pt 3 |pages= 777–85 |year= 2002 |pmid= 12059788 |doi= 10.1042/BJ20020525
*cite journal | author=Shen C, Nathan C |title=Nonredundant antioxidant defense by multiple two-cysteine peroxiredoxins in human prostate cancer cells. |journal=Mol. Med. |volume=8 |issue= 2 |pages= 95–102 |year= 2002 |pmid= 12080185 |doi=
*cite journal | author=Yang KS, Kang SW, Woo HA, "et al." |title=Inactivation of human peroxiredoxin I during catalysis as the result of the oxidation of the catalytic site cysteine to cysteine-sulfinic acid. |journal=J. Biol. Chem. |volume=277 |issue= 41 |pages= 38029–36 |year= 2002 |pmid= 12161445 |doi= 10.1074/jbc.M206626200
*cite journal | author=Geiben-Lynn R, Kursar M, Brown NV, "et al." |title=HIV-1 antiviral activity of recombinant natural killer cell enhancing factors, NKEF-A and NKEF-B, members of the peroxiredoxin family. |journal=J. Biol. Chem. |volume=278 |issue= 3 |pages= 1569–74 |year= 2003 |pmid= 12421812 |doi= 10.1074/jbc.M209964200

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