TEC (gene)

Tec protein tyrosine kinase, also known as TEC, is a human gene.cite web | title = Entrez Gene: TEC tec protein tyrosine kinase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7006| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene belongs to the Tec family of non-receptor protein-tyrosine kinases containing a pleckstrin homology domain. Tec family kinases are involved in the intracellular signaling mechanisms of cytokine receptors, lymphocyte surface antigens, heterotrimeric G-protein coupled receptors, and integrin molecules. They are also key players in the regulation of the immune functions. Tec kinase is an integral component of T cell signaling and has a distinct role in T cell activation. This gene may be associated with myelodysplastic syndrome.cite web | title = Entrez Gene: TEC tec protein tyrosine kinase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7006| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Mano H |title=Tec family of protein-tyrosine kinases: an overview of their structure and function |journal=Cytokine Growth Factor Rev. |volume=10 |issue= 3-4 |pages= 267–80 |year= 2000 |pmid= 10647781 |doi=
*cite journal | author=Yang WC, Collette Y, Nunès JA, Olive D |title=Tec kinases: a family with multiple roles in immunity |journal=Immunity |volume=12 |issue= 4 |pages= 373–82 |year= 2000 |pmid= 10795735 |doi=
*cite journal | author=Mano H, Ishikawa F, Nishida J, "et al." |title=A novel protein-tyrosine kinase, tec, is preferentially expressed in liver |journal=Oncogene |volume=5 |issue= 12 |pages= 1781–6 |year= 1991 |pmid= 2284097 |doi=
*cite journal | author=Tang B, Mano H, Yi T, Ihle JN |title=Tec kinase associates with c-kit and is tyrosine phosphorylated and activated following stem cell factor binding |journal=Mol. Cell. Biol. |volume=14 |issue= 12 |pages= 8432–7 |year= 1994 |pmid= 7526158 |doi=
*cite journal | author=Machide M, Mano H, Todokoro K |title=Interleukin 3 and erythropoietin induce association of Vav with Tec kinase through Tec homology domain |journal=Oncogene |volume=11 |issue= 4 |pages= 619–25 |year= 1995 |pmid= 7651724 |doi=
*cite journal | author=Sato K, Mano H, Ariyama T, "et al." |title=Molecular cloning and analysis of the human Tec protein-tyrosine kinase |journal=Leukemia |volume=8 |issue= 10 |pages= 1663–72 |year= 1994 |pmid= 7934162 |doi=
*cite journal | author=Mano H, Yamashita Y, Miyazato A, "et al." |title=Tec protein-tyrosine kinase is an effector molecule of Lyn protein-tyrosine kinase |journal=FASEB J. |volume=10 |issue= 5 |pages= 637–42 |year= 1996 |pmid= 8621063 |doi=
*cite journal | author=Rawlings DJ, Scharenberg AM, Park H, "et al." |title=Activation of BTK by a phosphorylation mechanism initiated by SRC family kinases |journal=Science |volume=271 |issue= 5250 |pages= 822–5 |year= 1996 |pmid= 8629002 |doi=
*cite journal | author=Park H, Wahl MI, Afar DE, "et al." |title=Regulation of Btk function by a major autophosphorylation site within the SH3 domain |journal=Immunity |volume=4 |issue= 5 |pages= 515–25 |year= 1996 |pmid= 8630736 |doi=
*cite journal | author=Ohta Y, Haire RN, Amemiya CT, "et al." |title=Human Txk: genomic organization, structure and contiguous physical linkage with the Tec gene |journal=Oncogene |volume=12 |issue= 4 |pages= 937–42 |year= 1996 |pmid= 8632917 |doi=
*cite journal | author=Cory GO, MacCarthy-Morrogh L, Banin S, "et al." |title=Evidence that the Wiskott-Aldrich syndrome protein may be involved in lymphoid cell signaling pathways |journal=J. Immunol. |volume=157 |issue= 9 |pages= 3791–5 |year= 1996 |pmid= 8892607 |doi=
*cite journal | author=Takahashi-Tezuka M, Hibi M, Fujitani Y, "et al." |title=Tec tyrosine kinase links the cytokine receptors to PI-3 kinase probably through JAK |journal=Oncogene |volume=14 |issue= 19 |pages= 2273–82 |year= 1997 |pmid= 9178903 |doi= 10.1038/sj.onc.1201071
*cite journal | author=Laffargue M, Monnereau L, Tuech J, "et al." |title=Integrin-dependent tyrosine phoshorylation and cytoskeletal translocation of Tec in thrombin-activated platelets |journal=Biochem. Biophys. Res. Commun. |volume=238 |issue= 1 |pages= 247–51 |year= 1997 |pmid= 9299487 |doi= 10.1006/bbrc.1997.7269
*cite journal | author=Ohya K, Kajigaya S, Yamashita Y, "et al." |title=SOCS-1/JAB/SSI-1 can bind to and suppress Tec protein-tyrosine kinase |journal=J. Biol. Chem. |volume=272 |issue= 43 |pages= 27178–82 |year= 1997 |pmid= 9341160 |doi=
*cite journal | author=Kitanaka A, Mano H, Conley ME, Campana D |title=Expression and activation of the nonreceptor tyrosine kinase Tec in human B cells |journal=Blood |volume=91 |issue= 3 |pages= 940–8 |year= 1998 |pmid= 9446655 |doi=
*cite journal | author=Yamashita Y, Watanabe S, Miyazato A, "et al." |title=Tec and Jak2 kinases cooperate to mediate cytokine-driven activation of c-fos transcription |journal=Blood |volume=91 |issue= 5 |pages= 1496–507 |year= 1998 |pmid= 9473212 |doi=
*cite journal | author=Yang WC, Ghiotto M, Barbarat B, Olive D |title=The role of Tec protein-tyrosine kinase in T cell signaling |journal=J. Biol. Chem. |volume=274 |issue= 2 |pages= 607–17 |year= 1999 |pmid= 9872994 |doi=
*cite journal | author=Yang WC, Olive D |title=Tec kinase is involved in transcriptional regulation of IL-2 and IL-4 in the CD28 pathway |journal=Eur. J. Immunol. |volume=29 |issue= 6 |pages= 1842–9 |year= 1999 |pmid= 10382746 |doi=
*cite journal | author=Ohya K, Kajigaya S, Kitanaka A, "et al." |title=Molecular cloning of a docking protein, BRDG1, that acts downstream of the Tec tyrosine kinase |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 21 |pages= 11976–81 |year= 1999 |pmid= 10518561 |doi=

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