S100A6


S100A6

S100 calcium binding protein A6, also known as S100A6, is a human gene.cite web | title = Entrez Gene: S100A6 S100 calcium binding protein A6| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6277| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in stimulation of Ca2+-dependent insulin release, stimulation of prolactin secretion, and exocytosis. Chromosomal rearrangements and altered expression of this gene have been implicated in melanoma.cite web | title = Entrez Gene: S100A6 S100 calcium binding protein A6| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6277| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Schäfer BW, Heizmann CW |title=The S100 family of EF-hand calcium-binding proteins: functions and pathology. |journal=Trends Biochem. Sci. |volume=21 |issue= 4 |pages= 134–40 |year= 1996 |pmid= 8701470 |doi=
*cite journal | author=Minami H, Tokumitsu H, Mizutani A, "et al." |title=Specific binding of CAP-50 to calcyclin. |journal=FEBS Lett. |volume=305 |issue= 3 |pages= 217–9 |year= 1993 |pmid= 1299619 |doi=
*cite journal | author=Engelkamp D, Schäfer BW, Erne P, Heizmann CW |title=S100 alpha, CAPL, and CACY: molecular cloning and expression analysis of three calcium-binding proteins from human heart. |journal=Biochemistry |volume=31 |issue= 42 |pages= 10258–64 |year= 1992 |pmid= 1384693 |doi=
*cite journal | author=Tomida Y, Terasawa M, Kobayashi R, Hidaka H |title=Calcyclin and calvasculin exist in human platelets. |journal=Biochem. Biophys. Res. Commun. |volume=189 |issue= 3 |pages= 1310–6 |year= 1993 |pmid= 1482346 |doi=
*cite journal | author=Filipek A, Gerke V, Weber K, Kuźnicki J |title=Characterization of the cell-cycle-regulated protein calcyclin from Ehrlich ascites tumor cells. Identification of two binding proteins obtained by Ca2(+)-dependent affinity chromatography. |journal=Eur. J. Biochem. |volume=195 |issue= 3 |pages= 795–800 |year= 1991 |pmid= 1999197 |doi=
*cite journal | author=Murphy LC, Murphy LJ, Tsuyuki D, "et al." |title=Cloning and characterization of a cDNA encoding a highly conserved, putative calcium binding protein, identified by an anti-prolactin receptor antiserum. |journal=J. Biol. Chem. |volume=263 |issue= 5 |pages= 2397–401 |year= 1988 |pmid= 2448309 |doi=
*cite journal | author=Gabius HJ, Bardosi A, Gabius S, "et al." |title=Identification of a cell cycle-dependent gene product as a sialic acid-binding protein. |journal=Biochem. Biophys. Res. Commun. |volume=163 |issue= 1 |pages= 506–12 |year= 1989 |pmid= 2775283 |doi=
*cite journal | author=Ferrari S, Calabretta B, deRiel JK, "et al." |title=Structural and functional analysis of a growth-regulated gene, the human calcyclin. |journal=J. Biol. Chem. |volume=262 |issue= 17 |pages= 8325–32 |year= 1987 |pmid= 3036810 |doi=
*cite journal | author=Calabretta B, Battini R, Kaczmarek L, "et al." |title=Molecular cloning of the cDNA for a growth factor-inducible gene with strong homology to S-100, a calcium-binding protein. |journal=J. Biol. Chem. |volume=261 |issue= 27 |pages= 12628–32 |year= 1986 |pmid= 3755724 |doi=
*cite journal | author=Schäfer BW, Wicki R, Engelkamp D, "et al." |title=Isolation of a YAC clone covering a cluster of nine S100 genes on human chromosome 1q21: rationale for a new nomenclature of the S100 calcium-binding protein family. |journal=Genomics |volume=25 |issue= 3 |pages= 638–43 |year= 1995 |pmid= 7759097 |doi=
*cite journal | author=Engelkamp D, Schäfer BW, Mattei MG, "et al." |title=Six S100 genes are clustered on human chromosome 1q21: identification of two genes coding for the two previously unreported calcium-binding proteins S100D and S100E. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=90 |issue= 14 |pages= 6547–51 |year= 1993 |pmid= 8341667 |doi=
*cite journal | author=Filipek A, Wojda U |title=p30, a novel protein target of mouse calcyclin (S100A6). |journal=Biochem. J. |volume=320 ( Pt 2) |issue= |pages= 585–7 |year= 1997 |pmid= 8973570 |doi=
*cite journal | author=Kordowska J, Stafford WF, Wang CL |title=Ca2+ and Zn2+ bind to different sites and induce different conformational changes in human calcyclin. |journal=Eur. J. Biochem. |volume=253 |issue= 1 |pages= 57–66 |year= 1998 |pmid= 9578461 |doi=
*cite journal | author=Yang Q, O'Hanlon D, Heizmann CW, Marks A |title=Demonstration of heterodimer formation between S100B and S100A6 in the yeast two-hybrid system and human melanoma. |journal=Exp. Cell Res. |volume=246 |issue= 2 |pages= 501–9 |year= 1999 |pmid= 9925766 |doi= 10.1006/excr.1998.4314
*cite journal | author=Sudo T, Hidaka H |title=Characterization of the calcyclin (S100A6) binding site of annexin XI-A by site-directed mutagenesis. |journal=FEBS Lett. |volume=444 |issue= 1 |pages= 11–4 |year= 1999 |pmid= 10037139 |doi=
*cite journal | author=Deloulme JC, Assard N, Mbele GO, "et al." |title=S100A6 and S100A11 are specific targets of the calcium- and zinc-binding S100B protein in vivo. |journal=J. Biol. Chem. |volume=275 |issue= 45 |pages= 35302–10 |year= 2001 |pmid= 10913138 |doi= 10.1074/jbc.M003943200
*cite journal | author=Li Y, Yang L, Cui JT, "et al." |title=Construction of cDNA representational difference analysis based on two cDNA libraries and identification of garlic inducible expression genes in human gastric cancer cells. |journal=World J. Gastroenterol. |volume=8 |issue= 2 |pages= 208–12 |year= 2002 |pmid= 11925593 |doi=
*cite journal | author=Otterbein LR, Kordowska J, Witte-Hoffmann C, "et al." |title=Crystal structures of S100A6 in the Ca(2+)-free and Ca(2+)-bound states: the calcium sensor mechanism of S100 proteins revealed at atomic resolution. |journal=Structure |volume=10 |issue= 4 |pages= 557–67 |year= 2002 |pmid= 11937060 |doi=
*cite journal | author=Filipek A, Jastrzebska B, Nowotny M, Kuznicki J |title=CacyBP/SIP, a calcyclin and Siah-1-interacting protein, binds EF-hand proteins of the S100 family. |journal=J. Biol. Chem. |volume=277 |issue= 32 |pages= 28848–52 |year= 2002 |pmid= 12042313 |doi= 10.1074/jbc.M203602200

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