Calsenilin

Kv channel interacting protein 3, calsenilin, also known as KCNIP3, is a human gene.cite web | title = Entrez Gene: KCNIP3 Kv channel interacting protein 3, calsenilin| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=30818| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins, which belong to the recoverin branch of the EF-hand superfamily. Members of this family are small calcium binding proteins containing EF-hand-like domains. They are integral subunit components of native Kv4 channel complexes that may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. The encoded protein also functions as a calcium-regulated transcriptional repressor, and interacts with presenilins. Alternatively spliced transcript variants encoding different isoforms have been described.cite web | title = Entrez Gene: KCNIP3 Kv channel interacting protein 3, calsenilin| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=30818| accessdate = ]

ee also

* Voltage-gated potassium channel

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Buxbaum JD, Choi EK, Luo Y, "et al." |title=Calsenilin: a calcium-binding protein that interacts with the presenilins and regulates the levels of a presenilin fragment. |journal=Nat. Med. |volume=4 |issue= 10 |pages= 1177–81 |year= 1998 |pmid= 9771752 |doi= 10.1038/2673
*cite journal | author=Carrión AM, Mellström B, Naranjo JR |title=Protein kinase A-dependent derepression of the human prodynorphin gene via differential binding to an intragenic silencer element. |journal=Mol. Cell. Biol. |volume=18 |issue= 12 |pages= 6921–9 |year= 1998 |pmid= 9819380 |doi=
*cite journal | author=Carrión AM, Link WA, Ledo F, "et al." |title=DREAM is a Ca2+-regulated transcriptional repressor. |journal=Nature |volume=398 |issue= 6722 |pages= 80–4 |year= 1999 |pmid= 10078534 |doi= 10.1038/18044
*cite journal | author=An WF, Bowlby MR, Betty M, "et al." |title=Modulation of A-type potassium channels by a family of calcium sensors. |journal=Nature |volume=403 |issue= 6769 |pages= 553–6 |year= 2000 |pmid= 10676964 |doi= 10.1038/35000592
*cite journal | author=Leissring MA, Yamasaki TR, Wasco W, "et al." |title=Calsenilin reverses presenilin-mediated enhancement of calcium signaling. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 15 |pages= 8590–3 |year= 2000 |pmid= 10900016 |doi=
*cite journal | author=Buxbaum JD, Lilliehook C, Chan JY, "et al." |title=Genomic structure, expression pattern, and chromosomal localization of the human calsenilin gene: no association between an exonic polymorphism and Alzheimer's disease. |journal=Neurosci. Lett. |volume=294 |issue= 3 |pages= 135–8 |year= 2000 |pmid= 11072133 |doi=
*cite journal | author=Ledo F, Carrión AM, Link WA, "et al." |title=DREAM-alphaCREM interaction via leucine-charged domains derepresses downstream regulatory element-dependent transcription. |journal=Mol. Cell. Biol. |volume=20 |issue= 24 |pages= 9120–6 |year= 2001 |pmid= 11094064 |doi=
*cite journal | author=Jo DG, Kim MJ, Choi YH, "et al." |title=Pro-apoptotic function of calsenilin/DREAM/KChIP3. |journal=FASEB J. |volume=15 |issue= 3 |pages= 589–91 |year= 2001 |pmid= 11259376 |doi= 10.1096/fj.00-0541fje
*cite journal | author=Choi EK, Zaidi NF, Miller JS, "et al." |title=Calsenilin is a substrate for caspase-3 that preferentially interacts with the familial Alzheimer's disease-associated C-terminal fragment of presenilin 2. |journal=J. Biol. Chem. |volume=276 |issue= 22 |pages= 19197–204 |year= 2001 |pmid= 11278424 |doi= 10.1074/jbc.M008597200
*cite journal | author=Osawa M, Tong KI, Lilliehook C, "et al." |title=Calcium-regulated DNA binding and oligomerization of the neuronal calcium-sensing protein, calsenilin/DREAM/KChIP3. |journal=J. Biol. Chem. |volume=276 |issue= 44 |pages= 41005–13 |year= 2001 |pmid= 11535596 |doi= 10.1074/jbc.M105842200
*cite journal | author=Cheng HY, Pitcher GM, Laviolette SR, "et al." |title=DREAM is a critical transcriptional repressor for pain modulation. |journal=Cell |volume=108 |issue= 1 |pages= 31–43 |year= 2002 |pmid= 11792319 |doi=
*cite journal | author=Lilliehook C, Chan S, Choi EK, "et al." |title=Calsenilin enhances apoptosis by altering endoplasmic reticulum calcium signaling. |journal=Mol. Cell. Neurosci. |volume=19 |issue= 4 |pages= 552–9 |year= 2002 |pmid= 11988022 |doi= 10.1006/mcne.2001.1096
*cite journal | author=Takimoto K, Yang EK, Conforti L |title=Palmitoylation of KChIP splicing variants is required for efficient cell surface expression of Kv4.3 channels. |journal=J. Biol. Chem. |volume=277 |issue= 30 |pages= 26904–11 |year= 2002 |pmid= 12006572 |doi= 10.1074/jbc.M203651200
*cite journal | author=Ledo F, Kremer L, Mellström B, Naranjo JR |title=Ca2+-dependent block of CREB-CBP transcription by repressor DREAM. |journal=EMBO J. |volume=21 |issue= 17 |pages= 4583–92 |year= 2002 |pmid= 12198160 |doi=
*cite journal | author=Zaidi NF, Berezovska O, Choi EK, "et al." |title=Biochemical and immunocytochemical characterization of calsenilin in mouse brain. |journal=Neuroscience |volume=114 |issue= 1 |pages= 247–63 |year= 2002 |pmid= 12207970 |doi=
*cite journal | author=Sanz C, Horita M, Fernandez-Luna JL |title=Fas signaling and blockade of Bcr-Abl kinase induce apoptotic Hrk protein via DREAM inhibition in human leukemia cells. |journal=Haematologica |volume=87 |issue= 9 |pages= 903–7 |year= 2004 |pmid= 12217801 |doi=
*cite journal | author=Schrader LA, Anderson AE, Mayne A, "et al." |title=PKA modulation of Kv4.2-encoded A-type potassium channels requires formation of a supramolecular complex. |journal=J. Neurosci. |volume=22 |issue= 23 |pages= 10123–33 |year= 2002 |pmid= 12451113 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Hong YM, Jo DG, Lee MC, "et al." |title=Reduced expression of calsenilin/DREAM/KChIP3 in the brains of kainic acid-induced seizure and epilepsy patients. |journal=Neurosci. Lett. |volume=340 |issue= 1 |pages= 33–6 |year= 2003 |pmid= 12648752 |doi=
*cite journal | author=Shibata R, Misonou H, Campomanes CR, "et al." |title=A fundamental role for KChIPs in determining the molecular properties and trafficking of Kv4.2 potassium channels. |journal=J. Biol. Chem. |volume=278 |issue= 38 |pages= 36445–54 |year= 2003 |pmid= 12829703 |doi= 10.1074/jbc.M306142200

External links

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