Glycoprotein IX

Glycoprotein IX

Glycoprotein IX (platelet) (GP9) also known as CD42a (Cluster of Differentiation 42a), is a human gene.cite web | title = Entrez Gene: GP9 glycoprotein IX (platelet)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2815| accessdate = ]

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summary_text = Platelet glycoprotein IX (GP9) is a small membrane glycoprotein found on the surface of human platelets. It forms a 1-to-1 noncovalent complex with glycoprotein Ib (GP Ib), a platelet surface membrane glycoprotein complex that functions as a receptor for von Willebrand factor (VWF; MIM 193400). The main portion of the receptor is a heterodimer composed of 2 polypeptide chains, an alpha chain (GP1BA; MIM 606672) and a beta chain (GP1BB; MIM 138720), that are linked by disulfide bonds. The complete receptor complex includes noncovalent association of the alpha and beta subunits with GP9 and platelet glycoprotein V (GP5; MIM 173511). [supplied by OMIM] cite web | title = Entrez Gene: GP9 glycoprotein IX (platelet)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2815| accessdate = ]

ee also

* Cluster of differentiation

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Kunishima S, Kamiya T, Saito H |title=Genetic abnormalities of Bernard-Soulier syndrome. |journal=Int. J. Hematol. |volume=76 |issue= 4 |pages= 319–27 |year= 2003 |pmid= 12463594 |doi=
*cite journal | author=Hickey MJ, Deaven LL, Roth GJ |title=Human platelet glycoprotein IX. Characterization of cDNA and localization of the gene to chromosome 3. |journal=FEBS Lett. |volume=274 |issue= 1-2 |pages= 189–92 |year= 1991 |pmid= 2253772 |doi=
*cite journal | author=Du X, Beutler L, Ruan C, "et al." |title=Glycoprotein Ib and glycoprotein IX are fully complexed in the intact platelet membrane. |journal=Blood |volume=69 |issue= 5 |pages= 1524–7 |year= 1987 |pmid= 2436691 |doi=
*cite journal | author=Andrews RK, Booth WJ, Gorman JJ, "et al." |title=Purification of botrocetin from Bothrops jararaca venom. Analysis of the botrocetin-mediated interaction between von Willebrand factor and the human platelet membrane glycoprotein Ib-IX complex. |journal=Biochemistry |volume=28 |issue= 21 |pages= 8317–26 |year= 1990 |pmid= 2557900 |doi=
*cite journal | author=Hickey MJ, Williams SA, Roth GJ |title=Human platelet glycoprotein IX: an adhesive prototype of leucine-rich glycoproteins with flank-center-flank structures. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=86 |issue= 17 |pages= 6773–7 |year= 1989 |pmid= 2771955 |doi=
*cite journal | author=Roth GJ, Ozols J, Nugent DJ, Williams SA |title=Isolation and characterization of human platelet glycoprotein IX. |journal=Biochem. Biophys. Res. Commun. |volume=156 |issue= 2 |pages= 931–9 |year= 1988 |pmid= 3056407 |doi=
*cite journal | author=Meyer SC, Fox JE |title=Interaction of platelet glycoprotein V with glycoprotein Ib-IX regulates expression of the glycoproteins and binding of von Willebrand factor to glycoprotein Ib-IX in transfected cells. |journal=J. Biol. Chem. |volume=270 |issue= 24 |pages= 14693–9 |year= 1995 |pmid= 7782333 |doi=
*cite journal | author=Clemetson JM, Kyrle PA, Brenner B, Clemetson KJ |title=Variant Bernard-Soulier syndrome associated with a homozygous mutation in the leucine-rich domain of glycoprotein IX. |journal=Blood |volume=84 |issue= 4 |pages= 1124–31 |year= 1994 |pmid= 8049428 |doi=
*cite journal | author=Hickey MJ, Roth GJ |title=Characterization of the gene encoding human platelet glycoprotein IX. |journal=J. Biol. Chem. |volume=268 |issue= 5 |pages= 3438–43 |year= 1993 |pmid= 8429020 |doi=
*cite journal | author=Wright SD, Michaelides K, Johnson DJ, "et al." |title=Double heterozygosity for mutations in the platelet glycoprotein IX gene in three siblings with Bernard-Soulier syndrome. |journal=Blood |volume=81 |issue= 9 |pages= 2339–47 |year= 1993 |pmid= 8481514 |doi=
*cite journal | author=Berger G, Massé JM, Cramer EM |title=Alpha-granule membrane mirrors the platelet plasma membrane and contains the glycoproteins Ib, IX, and V. |journal=Blood |volume=87 |issue= 4 |pages= 1385–95 |year= 1996 |pmid= 8608228 |doi=
*cite journal | author=Hollmann C, Haag F, Schlott M, "et al." |title=Molecular characterization of mouse T-cell ecto-ADP-ribosyltransferase Rt6: cloning of a second functional gene and identification of the Rt6 gene products. |journal=Mol. Immunol. |volume=33 |issue= 9 |pages= 807–17 |year= 1996 |pmid= 8811076 |doi=
*cite journal | author=Noris P, Simsek S, Stibbe J, von dem Borne AE |title=A phenylalanine-55 to serine amino-acid substitution in the human glycoprotein IX leucine-rich repeat is associated with Bernard-Soulier syndrome. |journal=Br. J. Haematol. |volume=97 |issue= 2 |pages= 312–20 |year= 1997 |pmid= 9163595 |doi=
*cite journal | author=Hayashi T, Suzuki K, Yahagi A, "et al." |title=Corrected DNA sequence of the platelet glycoprotein IX gene. |journal=Thromb. Haemost. |volume=77 |issue= 5 |pages= 1034–5 |year= 1997 |pmid= 9184424 |doi=
*cite journal | author=Bradford HN, Dela Cadena RA, Kunapuli SP, "et al." |title=Human kininogens regulate thrombin binding to platelets through the glycoprotein Ib-IX-V complex. |journal=Blood |volume=90 |issue= 4 |pages= 1508–15 |year= 1997 |pmid= 9269768 |doi=
*cite journal | author=Suzuki K, Hayashi T, Yahagi A, "et al." |title=Novel point mutation in the leucine-rich motif of the platelet glycoprotein IX associated with Bernard-Soulier syndrome. |journal=Br. J. Haematol. |volume=99 |issue= 4 |pages= 794–800 |year= 1998 |pmid= 9432024 |doi=
*cite journal | author=Noris P, Arbustini E, Spedini P, "et al." |title=A new variant of Bernard-Soulier syndrome characterized by dysfunctional glycoprotein (GP) Ib and severely reduced amounts of GPIX and GPV. |journal=Br. J. Haematol. |volume=103 |issue= 4 |pages= 1004–13 |year= 1999 |pmid= 9886312 |doi=
*cite journal | author=Longhurst CM, White MM, Wilkinson DA, Jennings LK |title=A CD9, alphaIIbbeta3, integrin-associated protein, and GPIb/V/IX complex on the surface of human platelets is influenced by alphaIIbbeta3 conformational states. |journal=Eur. J. Biochem. |volume=263 |issue= 1 |pages= 104–11 |year= 1999 |pmid= 10429193 |doi=
*cite journal | author=Kunishima S, Tomiyama Y, Honda S, "et al." |title=Cys97-->Tyr mutation in the glycoprotein IX gene associated with Bernard-Soulier syndrome. |journal=Br. J. Haematol. |volume=107 |issue= 3 |pages= 539–45 |year= 2000 |pmid= 10583255 |doi=
*cite journal | author=Rivera CE, Villagra J, Riordan M, "et al." |title=Identification of a new mutation in platelet glycoprotein IX (GPIX) in a patient with Bernard-Soulier syndrome. |journal=Br. J. Haematol. |volume=112 |issue= 1 |pages= 105–8 |year= 2001 |pmid= 11167791 |doi=

External links

*

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