KIR2DL1

KIR2DL1

Killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1, also known as KIR2DL1, is a human gene.cite web | title = Entrez Gene: KIR2DL1 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3802| accessdate = ]

PBB_Summary
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summary_text = Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response.cite web | title = Entrez Gene: KIR2DL1 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3802| accessdate = ]

ee also

* Cluster of differentiation

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Colonna M, Samaridis J |title=Cloning of immunoglobulin-superfamily members associated with HLA-C and HLA-B recognition by human natural killer cells. |journal=Science |volume=268 |issue= 5209 |pages= 405–8 |year= 1995 |pmid= 7716543 |doi=
*cite journal | author=Wagtmann N, Biassoni R, Cantoni C, "et al." |title=Molecular clones of the p58 NK cell receptor reveal immunoglobulin-related molecules with diversity in both the extra- and intracellular domains. |journal=Immunity |volume=2 |issue= 5 |pages= 439–49 |year= 1995 |pmid= 7749980 |doi=
*cite journal | author=Fan QR, Mosyak L, Winter CC, "et al." |title=Structure of the inhibitory receptor for human natural killer cells resembles haematopoietic receptors. |journal=Nature |volume=389 |issue= 6646 |pages= 96–100 |year= 1997 |pmid= 9288975 |doi= 10.1038/38028
*cite journal | author=Kim J, Chwae YJ, Kim MY, "et al." |title=Molecular basis of HLA-C recognition by p58 natural killer cell inhibitory receptors. |journal=J. Immunol. |volume=159 |issue= 8 |pages= 3875–82 |year= 1997 |pmid= 9378975 |doi=
*cite journal | author=Valiante NM, Uhrberg M, Shilling HG, "et al." |title=Functionally and structurally distinct NK cell receptor repertoires in the peripheral blood of two human donors. |journal=Immunity |volume=7 |issue= 6 |pages= 739–51 |year= 1998 |pmid= 9430220 |doi=
*cite journal | author=Uhrberg M, Valiante NM, Shum BP, "et al." |title=Human diversity in killer cell inhibitory receptor genes. |journal=Immunity |volume=7 |issue= 6 |pages= 753–63 |year= 1998 |pmid= 9430221 |doi=
*cite journal | author=Rajagopalan S, Long EO |title=Zinc bound to the killer cell-inhibitory receptor modulates the negative signal in human NK cells. |journal=J. Immunol. |volume=161 |issue= 3 |pages= 1299–305 |year= 1998 |pmid= 9686591 |doi=
*cite journal | author=Valés-Gómez M, Reyburn HT, Mandelboim M, Strominger JL |title=Kinetics of interaction of HLA-C ligands with natural killer cell inhibitory receptors. |journal=Immunity |volume=9 |issue= 3 |pages= 337–44 |year= 1998 |pmid= 9768753 |doi=
*cite journal | author=Shilling HG, Lienert-Weidenbach K, Valiante NM, "et al." |title=Evidence for recombination as a mechanism for KIR diversification. |journal=Immunogenetics |volume=48 |issue= 6 |pages= 413–6 |year= 1998 |pmid= 9799338 |doi=
*cite journal | author=Chwae YJ, Cho SE, Kim SJ, Kim J |title=Diversity of the repertoire of p58 killer cell inhibitory receptors in a single individual. |journal=Immunol. Lett. |volume=68 |issue= 2-3 |pages= 267–74 |year= 1999 |pmid= 10424431 |doi=
*cite journal | author=Fan QR, Wiley DC |title=Structure of human histocompatibility leukocyte antigen (HLA)-Cw4, a ligand for the KIR2D natural killer cell inhibitory receptor. |journal=J. Exp. Med. |volume=190 |issue= 1 |pages= 113–23 |year= 1999 |pmid= 10429675 |doi=
*cite journal | author=Richardson J, Reyburn HT, Luque I, "et al." |title=Definition of polymorphic residues on killer Ig-like receptor proteins which contribute to the HLA-C binding site. |journal=Eur. J. Immunol. |volume=30 |issue= 5 |pages= 1480–5 |year= 2000 |pmid= 10820396 |doi=
*cite journal | author=Fan QR, Long EO, Wiley DC |title=A disulfide-linked natural killer cell receptor dimer has higher affinity for HLA-C than wild-type monomer. |journal=Eur. J. Immunol. |volume=30 |issue= 9 |pages= 2692–7 |year= 2000 |pmid= 11009104 |doi= 10.1002/1521-4141(200009)30:9<2692::AID-IMMU2692>3.0.CO;2-0 |doilabel=10.1002/1521-4141(200009)30:92692::AID-IMMU26923.0.CO;2-0
*cite journal | author=Baba E, Erskine R, Boyson JE, "et al." |title=N-linked carbohydrate on human leukocyte antigen-C and recognition by natural killer cell inhibitory receptors. |journal=Hum. Immunol. |volume=61 |issue= 12 |pages= 1202–18 |year= 2001 |pmid= 11163076 |doi=
*cite journal | author=Rajalingam R, Gardiner CM, Canavez F, "et al." |title=Identification of seventeen novel KIR variants: fourteen of them from two non-Caucasian donors. |journal=Tissue Antigens |volume=57 |issue= 1 |pages= 22–31 |year= 2001 |pmid= 11169255 |doi=
*cite journal | author=Fan QR, Long EO, Wiley DC |title=Crystal structure of the human natural killer cell inhibitory receptor KIR2DL1-HLA-Cw4 complex. |journal=Nat. Immunol. |volume=2 |issue= 5 |pages= 452–60 |year= 2001 |pmid= 11323700 |doi= 10.1038/87766
*cite journal | author=Guerra N, Michel F, Gati A, "et al." |title=Engagement of the inhibitory receptor CD158a interrupts TCR signaling, preventing dynamic membrane reorganization in CTL/tumor cell interaction. |journal=Blood |volume=100 |issue= 8 |pages= 2874–81 |year= 2002 |pmid= 12351398 |doi= 10.1182/blood-2002-02-0643
*cite journal | author=Spaggiari GM, Contini P, Dondero A, "et al." |title=Soluble HLA class I induces NK cell apoptosis upon the engagement of killer-activating HLA class I receptors through FasL-Fas interaction. |journal=Blood |volume=100 |issue= 12 |pages= 4098–107 |year= 2003 |pmid= 12393468 |doi= 10.1182/blood-2002-04-1284
*cite journal | author=Boyson JE, Erskine R, Whitman MC, "et al." |title=Disulfide bond-mediated dimerization of HLA-G on the cell surface. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 25 |pages= 16180–5 |year= 2003 |pmid= 12454284 |doi= 10.1073/pnas.212643199
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899

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