CD93

CD93 (Cluster of Differentiation 93) is a human protein encoded by the gene|CD93 gene.cite web | title = Entrez Gene: CD93 CD93 molecule| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=22918| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene is a cell-surface glycoprotein and type I membrane protein that was originally identified as a myeloid cell-specific marker. The encoded protein was once thought to be a receptor for C1q, but now is thought to instead be involved in intercellular adhesion and in the clearance of apoptotic cells. The intracellular cytoplasmic tail of this protein has been found to interact with moesin, a protein known to play a role in linking transmembrane proteins to the cytoskeleton and in the remodelling of the cytoskeleton.cite web | title = Entrez Gene: CD93 CD93 molecule| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=22918| accessdate = ]

ee also

* Cluster of differentiation

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Tenner AJ |title=C1q receptors: regulating specific functions of phagocytic cells. |journal=Immunobiology |volume=199 |issue= 2 |pages= 250–64 |year= 1999 |pmid= 9777410 |doi=
*cite journal | author=Ghebrehiwet B, Peerschke EI, Hong Y, "et al." |title=Short amino acid sequences derived from C1q receptor (C1q-R) show homology with the alpha chains of fibronectin and vitronectin receptors and collagen type IV. |journal=J. Leukoc. Biol. |volume=51 |issue= 6 |pages= 546–56 |year= 1992 |pmid= 1377218 |doi=
*cite journal | author=Peerschke EI, Ghebrehiwet B |title=Platelet C1q receptor interactions with collagen- and C1q-coated surfaces. |journal=J. Immunol. |volume=145 |issue= 9 |pages= 2984–8 |year= 1990 |pmid= 2212670 |doi=
*cite journal | author=Eggleton P, Lieu TS, Zappi EG, "et al." |title=Calreticulin is released from activated neutrophils and binds to C1q and mannan-binding protein. |journal=Clin. Immunol. Immunopathol. |volume=72 |issue= 3 |pages= 405–9 |year= 1994 |pmid= 8062452 |doi=
*cite journal | author=Joseph K, Ghebrehiwet B, Peerschke EI, "et al." |title=Identification of the zinc-dependent endothelial cell binding protein for high molecular weight kininogen and factor XII: identity with the receptor that binds to the globular "heads" of C1q (gC1q-R). |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 16 |pages= 8552–7 |year= 1996 |pmid= 8710908 |doi=
*cite journal | author=Nepomuceno RR, Henschen-Edman AH, Burgess WH, Tenner AJ |title=cDNA cloning and primary structure analysis of C1qR(P), the human C1q/MBL/SPA receptor that mediates enhanced phagocytosis in vitro. |journal=Immunity |volume=6 |issue= 2 |pages= 119–29 |year= 1997 |pmid= 9047234 |doi=
*cite journal | author=Cáceres J, Brandan E |title=Interaction between Alzheimer's disease beta A4 precursor protein (APP) and the extracellular matrix: evidence for the participation of heparan sulfate proteoglycans. |journal=J. Cell. Biochem. |volume=65 |issue= 2 |pages= 145–58 |year= 1997 |pmid= 9136074 |doi=
*cite journal | author=Nepomuceno RR, Tenner AJ |title=C1qRP, the C1q receptor that enhances phagocytosis, is detected specifically in human cells of myeloid lineage, endothelial cells, and platelets. |journal=J. Immunol. |volume=160 |issue= 4 |pages= 1929–35 |year= 1998 |pmid= 9469455 |doi=
*cite journal | author=Stuart GR, Lynch NJ, Day AJ, "et al." |title=The C1q and collectin binding site within C1q receptor (cell surface calreticulin). |journal=Immunopharmacology |volume=38 |issue= 1-2 |pages= 73–80 |year= 1998 |pmid= 9476117 |doi=
*cite journal | author=Nepomuceno RR, Ruiz S, Park M, Tenner AJ |title=C1qRP is a heavily O-glycosylated cell surface protein involved in the regulation of phagocytic activity. |journal=J. Immunol. |volume=162 |issue= 6 |pages= 3583–9 |year= 1999 |pmid= 10092817 |doi=
*cite journal | author=Norsworthy PJ, Taylor PR, Walport MJ, Botto M |title=Cloning of the mouse homolog of the 126-kDa human C1q/MBL/SP-A receptor, C1qR(p). |journal=Mamm. Genome |volume=10 |issue= 8 |pages= 789–93 |year= 1999 |pmid= 10430665 |doi=
*cite journal | author=Webster SD, Park M, Fonseca MI, Tenner AJ |title=Structural and functional evidence for microglial expression of C1qR(P), the C1q receptor that enhances phagocytosis. |journal=J. Leukoc. Biol. |volume=67 |issue= 1 |pages= 109–16 |year= 2000 |pmid= 10648005 |doi=
*cite journal | author=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination. |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788–95 |year= 2001 |pmid= 11076863 |doi=
*cite journal | author=Kittlesen DJ, Chianese-Bullock KA, Yao ZQ, "et al." |title=Interaction between complement receptor gC1qR and hepatitis C virus core protein inhibits T-lymphocyte proliferation. |journal=J. Clin. Invest. |volume=106 |issue= 10 |pages= 1239–49 |year= 2001 |pmid= 11086025 |doi=
*cite journal | author=Joseph K, Shibayama Y, Ghebrehiwet B, Kaplan AP |title=Factor XII-dependent contact activation on endothelial cells and binding proteins gC1qR and cytokeratin 1. |journal=Thromb. Haemost. |volume=85 |issue= 1 |pages= 119–24 |year= 2001 |pmid= 11204562 |doi=
*cite journal | author=Simpson JC, Wellenreuther R, Poustka A, "et al." |title=Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. |journal=EMBO Rep. |volume=1 |issue= 3 |pages= 287–92 |year= 2001 |pmid= 11256614 |doi= 10.1093/embo-reports/kvd058
*cite journal | author=Deloukas P, Matthews LH, Ashurst J, "et al." |title=The DNA sequence and comparative analysis of human chromosome 20. |journal=Nature |volume=414 |issue= 6866 |pages= 865–71 |year= 2002 |pmid= 11780052 |doi= 10.1038/414865a
*cite journal | author=Steinberger P, Szekeres A, Wille S, "et al." |title=Identification of human CD93 as the phagocytic C1q receptor (C1qRp) by expression cloning. |journal=J. Leukoc. Biol. |volume=71 |issue= 1 |pages= 133–40 |year= 2002 |pmid= 11781389 |doi=
*cite journal | author=McGreal EP, Ikewaki N, Akatsu H, "et al." |title=Human C1qRp is identical with CD93 and the mNI-11 antigen but does not bind C1q. |journal=J. Immunol. |volume=168 |issue= 10 |pages= 5222–32 |year= 2002 |pmid= 11994479 |doi=

External links

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