SLC22A6

SLC22A6

Solute carrier family 22 (organic anion transporter), member 6, also known as SLC22A6, is a human gene.cite web | title = Entrez Gene: SLC22A6 solute carrier family 22 (organic anion transporter), member 6| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9356| accessdate = ]

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summary_text = The protein encoded by this gene is involved in the sodium-dependent transport and excretion of organic anions, some of which are potentially toxic. The encoded protein is an integral membrane protein and may be localized to the basolateral membrane. Five transcript variants encoding five different isoforms have been found for this gene.cite web | title = Entrez Gene: SLC22A6 solute carrier family 22 (organic anion transporter), member 6| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9356| accessdate = ]

ee also

* Solute carrier family

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Reid G, Wolff NA, Dautzenberg FM, Burckhardt G |title=Cloning of a human renal p-aminohippurate transporter, hROAT1. |journal=Kidney Blood Press. Res. |volume=21 |issue= 2-4 |pages= 233–7 |year= 1999 |pmid= 9762842 |doi=
*cite journal | author=Hosoyamada M, Sekine T, Kanai Y, Endou H |title=Molecular cloning and functional expression of a multispecific organic anion transporter from human kidney. |journal=Am. J. Physiol. |volume=276 |issue= 1 Pt 2 |pages= F122–8 |year= 1999 |pmid= 9887087 |doi=
*cite journal | author=Lu R, Chan BS, Schuster VL |title=Cloning of the human kidney PAH transporter: narrow substrate specificity and regulation by protein kinase C. |journal=Am. J. Physiol. |volume=276 |issue= 2 Pt 2 |pages= F295–303 |year= 1999 |pmid= 9950961 |doi=
*cite journal | author=Race JE, Grassl SM, Williams WJ, Holtzman EJ |title=Molecular cloning and characterization of two novel human renal organic anion transporters (hOAT1 and hOAT3). |journal=Biochem. Biophys. Res. Commun. |volume=255 |issue= 2 |pages= 508–14 |year= 1999 |pmid= 10049739 |doi= 10.1006/bbrc.1998.9978
*cite journal | author=Cihlar T, Lin DC, Pritchard JB, "et al." |title=The antiviral nucleotide analogs cidofovir and adefovir are novel substrates for human and rat renal organic anion transporter 1. |journal=Mol. Pharmacol. |volume=56 |issue= 3 |pages= 570–80 |year= 1999 |pmid= 10462545 |doi=
*cite journal | author=Bahn A, Prawitt D, Buttler D, "et al." |title=Genomic structure and in vivo expression of the human organic anion transporter 1 (hOAT1) gene. |journal=Biochem. Biophys. Res. Commun. |volume=275 |issue= 2 |pages= 623–30 |year= 2000 |pmid= 10964714 |doi= 10.1006/bbrc.2000.3230
*cite journal | author=Babu E, Takeda M, Narikawa S, "et al." |title=Human organic anion transporters mediate the transport of tetracycline. |journal=Jpn. J. Pharmacol. |volume=88 |issue= 1 |pages= 69–76 |year= 2002 |pmid= 11855680 |doi=
*cite journal | author=Burckhardt BC, Brai S, Wallis S, "et al." |title=Transport of cimetidine by flounder and human renal organic anion transporter 1. |journal=Am. J. Physiol. Renal Physiol. |volume=284 |issue= 3 |pages= F503–9 |year= 2003 |pmid= 12429554 |doi= 10.1152/ajprenal.00290.2002
*cite journal | author=Ichida K, Hosoyamada M, Kimura H, "et al." |title=Urate transport via human PAH transporter hOAT1 and its gene structure. |journal=Kidney Int. |volume=63 |issue= 1 |pages= 143–55 |year= 2004 |pmid= 12472777 |doi= 10.1046/j.1523-1755.2003.00710.x
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Wolff NA, Thies K, Kuhnke N, "et al." |title=Protein kinase C activation downregulates human organic anion transporter 1-mediated transport through carrier internalization. |journal=J. Am. Soc. Nephrol. |volume=14 |issue= 8 |pages= 1959–68 |year= 2004 |pmid= 12874449 |doi=
*cite journal | author=Sauvant C, Hesse D, Holzinger H, "et al." |title=Action of EGF and PGE2 on basolateral organic anion uptake in rabbit proximal renal tubules and hOAT1 expressed in human kidney epithelial cells. |journal=Am. J. Physiol. Renal Physiol. |volume=286 |issue= 4 |pages= F774–83 |year= 2004 |pmid= 14644751 |doi= 10.1152/ajprenal.00326.2003
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Tanaka K, Xu W, Zhou F, You G |title=Role of glycosylation in the organic anion transporter OAT1. |journal=J. Biol. Chem. |volume=279 |issue= 15 |pages= 14961–6 |year= 2004 |pmid= 14749323 |doi= 10.1074/jbc.M400197200
*cite journal | author=Sakurai Y, Motohashi H, Ueo H, "et al." |title=Expression levels of renal organic anion transporters (OATs) and their correlation with anionic drug excretion in patients with renal diseases. |journal=Pharm. Res. |volume=21 |issue= 1 |pages= 61–7 |year= 2004 |pmid= 14984259 |doi=
*cite journal | author=Bahn A, Ebbinghaus C, Ebbinghaus D, "et al." |title=Expression studies and functional characterization of renal human organic anion transporter 1 isoforms. |journal=Drug Metab. Dispos. |volume=32 |issue= 4 |pages= 424–30 |year= 2005 |pmid= 15039295 |doi= 10.1124/dmd.32.4.424
*cite journal | author=Hong M, Zhou F, You G |title=Critical amino acid residues in transmembrane domain 1 of the human organic anion transporter hOAT1. |journal=J. Biol. Chem. |volume=279 |issue= 30 |pages= 31478–82 |year= 2004 |pmid= 15145940 |doi= 10.1074/jbc.M404686200
*cite journal | author=Zalups RK, Aslamkhan AG, Ahmad S |title=Human organic anion transporter 1 mediates cellular uptake of cysteine-S conjugates of inorganic mercury. |journal=Kidney Int. |volume=66 |issue= 1 |pages= 251–61 |year= 2005 |pmid= 15200431 |doi= 10.1111/j.1523-1755.2004.00726.x
*cite journal | author=Zalups RK, Ahmad S |title=Homocysteine and the renal epithelial transport and toxicity of inorganic mercury: role of basolateral transporter organic anion transporter 1. |journal=J. Am. Soc. Nephrol. |volume=15 |issue= 8 |pages= 2023–31 |year= 2004 |pmid= 15284288 |doi= 10.1097/01.ASN.0000135115.63412.A9
*cite journal | author=Fujita T, Brown C, Carlson EJ, "et al." |title=Functional analysis of polymorphisms in the organic anion transporter, SLC22A6 (OAT1). |journal=Pharmacogenet. Genomics |volume=15 |issue= 4 |pages= 201–9 |year= 2005 |pmid= 15864112 |doi=

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