MIP (gene)

Major intrinsic protein of lens fiber, also known as MIP, is a human gene.cite web | title = Entrez Gene: MIP major intrinsic protein of lens fiber| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4284| accessdate = ]

PBB_Summary
section_title =
summary_text = Major intrinsic protein is a member of the water-transporting aquaporins as well as the original member of the MIP family of channel proteins. The function of the fiber cell membrane protein encoded by this gene is undetermined, yet this protein is speculated to play a role in intracellular communication. The MIP protein is expressed in the ocular lens and is required for correct lens function. This gene has been mapped among aquaporins AQP2, AQP5, and AQP6, in a potential gene cluster at 12q13.cite web | title = Entrez Gene: MIP major intrinsic protein of lens fiber| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4284| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Chepelinsky AB, Piatigorsky J, Pisano MM, "et al." |title=Lens protein gene expression: alpha-crystallins and MIP. |journal=Lens and eye toxicity research |volume=8 |issue= 2-3 |pages= 319–44 |year= 1991 |pmid= 1911643 |doi=
*cite journal | author=Griffin CS, Shiels A |title=In situ hybridisation localises the gene for the major intrinsic protein of eye lens fibre cell membranes to human chromosome 12q14. |journal=Cytogenet. Cell Genet. |volume=61 |issue= 1 |pages= 8–9 |year= 1992 |pmid= 1505237 |doi=
*cite journal | author=Girsch SJ, Peracchia C |title=Calmodulin interacts with a C-terminus peptide from the lens membrane protein MIP26. |journal=Curr. Eye Res. |volume=10 |issue= 9 |pages= 839–49 |year= 1992 |pmid= 1790714 |doi=
*cite journal | author=Pisano MM, Chepelinsky AB |title=Genomic cloning, complete nucleotide sequence, and structure of the human gene encoding the major intrinsic protein (MIP) of the lens. |journal=Genomics |volume=11 |issue= 4 |pages= 981–90 |year= 1992 |pmid= 1840563 |doi=
*cite journal | author=Lampe PD, Johnson RG |title=Amino acid sequence of in vivo phosphorylation sites in the main intrinsic protein (MIP) of lens membranes. |journal=Eur. J. Biochem. |volume=194 |issue= 2 |pages= 541–7 |year= 1991 |pmid= 2176601 |doi=
*cite journal | author=Manenti S, Dunia I, Benedetti EL |title=Fatty acid acylation of lens fiber plasma membrane proteins. MP26 and alpha-crystallin are palmitoylated. |journal=FEBS Lett. |volume=262 |issue= 2 |pages= 356–8 |year= 1990 |pmid= 2335219 |doi=
*cite journal | author=Peracchia C, Girsch SJ |title=Calmodulin site at the C-terminus of the putative lens gap junction protein MIP26. |journal=Lens and eye toxicity research |volume=6 |issue= 4 |pages= 613–21 |year= 1991 |pmid= 2487274 |doi=
*cite journal | author=Saito F, Sasaki S, Chepelinsky AB, "et al." |title=Human AQP2 and MIP genes, two members of the MIP family, map within chromosome band 12q13 on the basis of two-color FISH. |journal=Cytogenet. Cell Genet. |volume=68 |issue= 1-2 |pages= 45–8 |year= 1994 |pmid= 7525161 |doi=
*cite journal | author=Mulders SM, Preston GM, Deen PM, "et al." |title=Water channel properties of major intrinsic protein of lens. |journal=J. Biol. Chem. |volume=270 |issue= 15 |pages= 9010–16 |year= 1995 |pmid= 7536742 |doi=
*cite journal | author=Jarvis LJ, Louis CF |title=Purification and oligomeric state of the major lens fiber cell membrane proteins. |journal=Curr. Eye Res. |volume=14 |issue= 9 |pages= 799–808 |year= 1996 |pmid= 8529419 |doi=
*cite journal | author=Wang XY, Ohtaka-Maruyama C, Pisano MM, "et al." |title=Isolation and characterization of the 5'-flanking sequence of the human ocular lens MIP gene. |journal=Gene |volume=167 |issue= 1-2 |pages= 321–5 |year= 1996 |pmid= 8566800 |doi=
*cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=
*cite journal | author=Prabhakaram M, Katz ML, Ortwerth BJ |title=Glycation mediated crosslinking between alpha-crystallin and MP26 in intact lens membranes. |journal=Mech. Ageing Dev. |volume=91 |issue= 1 |pages= 65–78 |year= 1997 |pmid= 8910261 |doi=
*cite journal | author=Ma T, Yang B, Umenishi F, Verkman AS |title=Closely spaced tandem arrangement of AQP2, AQP5, and AQP6 genes in a 27-kilobase segment at chromosome locus 12q13. |journal=Genomics |volume=43 |issue= 3 |pages= 387–9 |year= 1997 |pmid= 9268644 |doi= 10.1006/geno.1997.4836
*cite journal | author=Ohtaka-Maruyama C, Wang X, Ge H, Chepelinsky AB |title=Overlapping Sp1 and AP2 binding sites in a promoter element of the lens-specific MIP gene. |journal=Nucleic Acids Res. |volume=26 |issue= 2 |pages= 407–14 |year= 1998 |pmid= 9421492 |doi=
*cite journal | author=Dunia I, Recouvreur M, Nicolas P, "et al." |title=Assembly of connexins and MP26 in lens fiber plasma membranes studied by SDS-fracture immunolabeling. |journal=J. Cell. Sci. |volume=111 ( Pt 15) |issue= |pages= 2109–20 |year= 1998 |pmid= 9664032 |doi=
*cite journal | author=Schey KL, Fowler JG, Shearer TR, David L |title=Modifications to rat lens major intrinsic protein in selenite-induced cataract. |journal=Invest. Ophthalmol. Vis. Sci. |volume=40 |issue= 3 |pages= 657–67 |year= 1999 |pmid= 10067969 |doi=
*cite journal | author=Schey KL, Little M, Fowler JG, Crouch RK |title=Characterization of human lens major intrinsic protein structure. |journal=Invest. Ophthalmol. Vis. Sci. |volume=41 |issue= 1 |pages= 175–82 |year= 2000 |pmid= 10634618 |doi=
*cite journal | author=Berry V, Francis P, Kaushal S, "et al." |title=Missense mutations in MIP underlie autosomal dominant 'polymorphic' and lamellar cataracts linked to 12q. |journal=Nat. Genet. |volume=25 |issue= 1 |pages= 15–7 |year= 2000 |pmid= 10802646 |doi= 10.1038/75538

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