GRK5

GRK5

G protein-coupled receptor kinase 5, also known as GRK5, is a human gene.cite web | title = Entrez Gene: GRK5 G protein-coupled receptor kinase 5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2869| accessdate = ]

PBB_Summary
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summary_text = This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating their deactivation. It has also been shown to play a role in regulating the motility of polymorphonuclear leukocytes (PMNs).cite web | title = Entrez Gene: GRK5 G protein-coupled receptor kinase 5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2869| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Kunapuli P, Benovic JL |title=Cloning and expression of GRK5: a member of the G protein-coupled receptor kinase family. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=90 |issue= 12 |pages= 5588–92 |year= 1993 |pmid= 7685906 |doi=
*cite journal | author=Bullrich F, Druck T, Kunapuli P, "et al." |title=Chromosomal mapping of the genes GPRK5 and GPRK6 encoding G protein-coupled receptor kinases GRK5 and GRK6. |journal=Cytogenet. Cell Genet. |volume=70 |issue= 3-4 |pages= 250–4 |year= 1995 |pmid= 7789183 |doi=
*cite journal | author=Kunapuli P, Gurevich VV, Benovic JL |title=Phospholipid-stimulated autophosphorylation activates the G protein-coupled receptor kinase GRK5. |journal=J. Biol. Chem. |volume=269 |issue= 14 |pages= 10209–12 |year= 1994 |pmid= 8144599 |doi=
*cite journal | author=Kunapuli P, Onorato JJ, Hosey MM, Benovic JL |title=Expression, purification, and characterization of the G protein-coupled receptor kinase GRK5. |journal=J. Biol. Chem. |volume=269 |issue= 2 |pages= 1099–105 |year= 1994 |pmid= 8288567 |doi=
*cite journal | author=Nagayama Y, Tanaka K, Hara T, "et al." |title=Involvement of G protein-coupled receptor kinase 5 in homologous desensitization of the thyrotropin receptor. |journal=J. Biol. Chem. |volume=271 |issue= 17 |pages= 10143–8 |year= 1996 |pmid= 8626574 |doi=
*cite journal | author=Oppermann M, Freedman NJ, Alexander RW, Lefkowitz RJ |title=Phosphorylation of the type 1A angiotensin II receptor by G protein-coupled receptor kinases and protein kinase C. |journal=J. Biol. Chem. |volume=271 |issue= 22 |pages= 13266–72 |year= 1996 |pmid= 8662816 |doi=
*cite journal | author=Fredericks ZL, Pitcher JA, Lefkowitz RJ |title=Identification of the G protein-coupled receptor kinase phosphorylation sites in the human beta2-adrenergic receptor. |journal=J. Biol. Chem. |volume=271 |issue= 23 |pages= 13796–803 |year= 1996 |pmid= 8662852 |doi=
*cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=
*cite journal | author=Pronin AN, Carman CV, Benovic JL |title=Structure-function analysis of G protein-coupled receptor kinase-5. Role of the carboxyl terminus in kinase regulation. |journal=J. Biol. Chem. |volume=273 |issue= 47 |pages= 31510–8 |year= 1998 |pmid= 9813065 |doi=
*cite journal | author=Premont RT, Claing A, Vitale N, "et al." |title=beta2-Adrenergic receptor regulation by GIT1, a G protein-coupled receptor kinase-associated ADP ribosylation factor GTPase-activating protein. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 24 |pages= 14082–7 |year= 1998 |pmid= 9826657 |doi=
*cite journal | author=Carman CV, Lisanti MP, Benovic JL |title=Regulation of G protein-coupled receptor kinases by caveolin. |journal=J. Biol. Chem. |volume=274 |issue= 13 |pages= 8858–64 |year= 1999 |pmid= 10085129 |doi=
*cite journal | author=Brenninkmeijer CB, Price SA, López Bernal A, Phaneuf S |title=Expression of G-protein-coupled receptor kinases in pregnant term and non-pregnant human myometrium. |journal=J. Endocrinol. |volume=162 |issue= 3 |pages= 401–8 |year= 1999 |pmid= 10467231 |doi=
*cite journal | author=Okochi M, Walter J, Koyama A, "et al." |title=Constitutive phosphorylation of the Parkinson's disease associated alpha-synuclein. |journal=J. Biol. Chem. |volume=275 |issue= 1 |pages= 390–7 |year= 2000 |pmid= 10617630 |doi=
*cite journal | author=Pronin AN, Morris AJ, Surguchov A, Benovic JL |title=Synucleins are a novel class of substrates for G protein-coupled receptor kinases. |journal=J. Biol. Chem. |volume=275 |issue= 34 |pages= 26515–22 |year= 2000 |pmid= 10852916 |doi= 10.1074/jbc.M003542200
*cite journal | author=Berrada K, Plesnicher CL, Luo X, Thibonnier M |title=Dynamic interaction of human vasopressin/oxytocin receptor subtypes with G protein-coupled receptor kinases and protein kinase C after agonist stimulation. |journal=J. Biol. Chem. |volume=275 |issue= 35 |pages= 27229–37 |year= 2000 |pmid= 10858434 |doi= 10.1074/jbc.M002288200
*cite journal | author=Zhou H, Yan F, Tai HH |title=Phosphorylation and desensitization of the human thromboxane receptor-alpha by G protein-coupled receptor kinases. |journal=J. Pharmacol. Exp. Ther. |volume=298 |issue= 3 |pages= 1243–51 |year= 2001 |pmid= 11504827 |doi=
*cite journal | author=Blaukat A, Pizard A, Breit A, "et al." |title=Determination of bradykinin B2 receptor in vivo phosphorylation sites and their role in receptor function. |journal=J. Biol. Chem. |volume=276 |issue= 44 |pages= 40431–40 |year= 2001 |pmid= 11517230 |doi= 10.1074/jbc.M107024200
*cite journal | author=Hu LA, Chen W, Premont RT, "et al." |title=G protein-coupled receptor kinase 5 regulates beta 1-adrenergic receptor association with PSD-95. |journal=J. Biol. Chem. |volume=277 |issue= 2 |pages= 1607–13 |year= 2002 |pmid= 11700307 |doi= 10.1074/jbc.M107297200
*cite journal | author=Warabi K, Richardson MD, Barry WT, "et al." |title=Human substance P receptor undergoes agonist-dependent phosphorylation by G protein-coupled receptor kinase 5 in vitro. |journal=FEBS Lett. |volume=521 |issue= 1-3 |pages= 140–4 |year= 2002 |pmid= 12067742 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899

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