- HES1
Hairy and enhancer of split 1, (Drosophila), also known as HES1, is a human
gene .cite web | title = Entrez Gene: HES1 hairy and enhancer of split 1, (Drosophila)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3280| accessdate = ]PBB_Summary
section_title =
summary_text = This protein belongs to the basic helix-loop-helix family of transcription factors. It is a transcriptional repressor of genes that require a bHLH protein for their transcription. The protein has a particular type of basic domain that contains a helix interrupting protein that binds to the N-box rather than the canonical E-box.cite web | title = Entrez Gene: HES1 hairy and enhancer of split 1, (Drosophila)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3280| accessdate = ]References
Further reading
PBB_Further_reading
citations =
*cite journal | author=Takebayashi K, Sasai Y, Sakai Y, "et al." |title=Structure, chromosomal locus, and promoter analysis of the gene encoding the mouse helix-loop-helix factor HES-1. Negative autoregulation through the multiple N box elements. |journal=J. Biol. Chem. |volume=269 |issue= 7 |pages= 5150–6 |year= 1994 |pmid= 7906273 |doi=
*cite journal | author=Feder JN, Li L, Jan LY, Jan YN |title=Genomic cloning and chromosomal localization of HRY, the human homolog to the Drosophila segmentation gene, hairy. |journal=Genomics |volume=20 |issue= 1 |pages= 56–61 |year= 1994 |pmid= 8020957 |doi= 10.1006/geno.1994.1126
*cite journal | author=Grbavec D, Stifani S |title=Molecular interaction between TLE1 and the carboxyl-terminal domain of HES-1 containing the WRPW motif. |journal=Biochem. Biophys. Res. Commun. |volume=223 |issue= 3 |pages= 701–5 |year= 1996 |pmid= 8687460 |doi= 10.1006/bbrc.1996.0959
*cite journal | author=Ström A, Castella P, Rockwood J, "et al." |title=Mediation of NGF signaling by post-translational inhibition of HES-1, a basic helix-loop-helix repressor of neuronal differentiation. |journal=Genes Dev. |volume=11 |issue= 23 |pages= 3168–81 |year= 1998 |pmid= 9389649 |doi=
*cite journal | author=Votruba M, Payne A, Moore AT, Bhattacharya SS |title=Dominant optic atrophy: exclusion and fine genetic mapping of the candidate gene, HRY. |journal=Mamm. Genome |volume=9 |issue= 10 |pages= 784–7 |year= 1998 |pmid= 9745030 |doi=
*cite journal | author=Bae S, Bessho Y, Hojo M, Kageyama R |title=The bHLH gene Hes6, an inhibitor of Hes1, promotes neuronal differentiation. |journal=Development |volume=127 |issue= 13 |pages= 2933–43 |year= 2000 |pmid= 10851137 |doi=
*cite journal | author=Yao J, Lai E, Stifani S |title=The winged-helix protein brain factor 1 interacts with groucho and hes proteins to repress transcription. |journal=Mol. Cell. Biol. |volume=21 |issue= 6 |pages= 1962–72 |year= 2001 |pmid= 11238932 |doi= 10.1128/MCB.21.6.1962-1972.2001
*cite journal | author=Iso T, Sartorelli V, Poizat C, "et al." |title=HERP, a novel heterodimer partner of HES/E(spl) in Notch signaling. |journal=Mol. Cell. Biol. |volume=21 |issue= 17 |pages= 6080–9 |year= 2001 |pmid= 11486045 |doi=
*cite journal | author=Dintilhac A, Bernués J |title=HMGB1 interacts with many apparently unrelated proteins by recognizing short amino acid sequences. |journal=J. Biol. Chem. |volume=277 |issue= 9 |pages= 7021–8 |year= 2002 |pmid= 11748221 |doi= 10.1074/jbc.M108417200
*cite journal | author=Jögi A, Persson P, Grynfeld A, "et al." |title=Modulation of basic helix-loop-helix transcription complex formation by Id proteins during neuronal differentiation. |journal=J. Biol. Chem. |volume=277 |issue= 11 |pages= 9118–26 |year= 2002 |pmid= 11756408 |doi= 10.1074/jbc.M107713200
*cite journal | author=Kunisato A, Chiba S, Nakagami-Yamaguchi E, "et al." |title=HES-1 preserves purified hematopoietic stem cells ex vivo and accumulates side population cells in vivo. |journal=Blood |volume=101 |issue= 5 |pages= 1777–83 |year= 2003 |pmid= 12406868 |doi= 10.1182/blood-2002-07-2051
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Takata T, Ishikawa F |title=Human Sir2-related protein SIRT1 associates with the bHLH repressors HES1 and HEY2 and is involved in HES1- and HEY2-mediated transcriptional repression. |journal=Biochem. Biophys. Res. Commun. |volume=301 |issue= 1 |pages= 250–7 |year= 2003 |pmid= 12535671 |doi=
*cite journal | author=Gratton MO, Torban E, Jasmin SB, "et al." |title=Hes6 promotes cortical neurogenesis and inhibits Hes1 transcription repression activity by multiple mechanisms. |journal=Mol. Cell. Biol. |volume=23 |issue= 19 |pages= 6922–35 |year= 2003 |pmid= 12972610 |doi=
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Thomsen JS, Kietz S, Ström A, Gustafsson JA |title=HES-1, a novel target gene for the aryl hydrocarbon receptor. |journal=Mol. Pharmacol. |volume=65 |issue= 1 |pages= 165–71 |year= 2004 |pmid= 14722248 |doi= 10.1124/mol.65.1.165
*cite journal | author=Kamakura S, Oishi K, Yoshimatsu T, "et al." |title=Hes binding to STAT3 mediates crosstalk between Notch and JAK-STAT signalling. |journal=Nat. Cell Biol. |volume=6 |issue= 6 |pages= 547–54 |year= 2004 |pmid= 15156153 |doi= 10.1038/ncb1138
*cite journal | author=Persson P, Stockhausen MT, Påhlman S, Axelson H |title=Ubiquilin-1 is a novel HASH-1-complexing protein that regulates levels of neuronal bHLH transcription factors in human neuroblastoma cells. |journal=Int. J. Oncol. |volume=25 |issue= 5 |pages= 1213–21 |year= 2005 |pmid= 15492808 |doi=
*cite journal | author=Aguilera C, Hoya-Arias R, Haegeman G, "et al." |title=Recruitment of IkappaBalpha to the hes1 promoter is associated with transcriptional repression. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 47 |pages= 16537–42 |year= 2004 |pmid= 15536134 |doi= 10.1073/pnas.0404429101
*cite journal | author=Fryer CJ, White JB, Jones KA |title=Mastermind recruits CycC:CDK8 to phosphorylate the Notch ICD and coordinate activation with turnover. |journal=Mol. Cell |volume=16 |issue= 4 |pages= 509–20 |year= 2005 |pmid= 15546612 |doi= 10.1016/j.molcel.2004.10.014External links
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