S100P

S100 calcium binding protein P, also known as S100P, is a human gene.cite web | title = Entrez Gene: S100P S100 calcium binding protein P| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6286| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21; however, this gene is located at 4p16. This protein, in addition to binding Ca²⁺, also binds Zn²⁺ and Mg²⁺. This protein may play a role in the etiology of prostate cancer.cite web | title = Entrez Gene: S100P S100 calcium binding protein P| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6286| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Schäfer BW, Heizmann CW |title=The S100 family of EF-hand calcium-binding proteins: functions and pathology. |journal=Trends Biochem. Sci. |volume=21 |issue= 4 |pages= 134–40 |year= 1996 |pmid= 8701470 |doi=
*cite journal | author=Emoto Y, Kobayashi R, Akatsuka H, Hidaka H |title=Purification and characterization of a new member of the S-100 protein family from human placenta. |journal=Biochem. Biophys. Res. Commun. |volume=182 |issue= 3 |pages= 1246–53 |year= 1992 |pmid= 1540168 |doi=
*cite journal | author=Becker T, Gerke V, Kube E, Weber K |title=S100P, a novel Ca(2+)-binding protein from human placenta. cDNA cloning, recombinant protein expression and Ca2+ binding properties. |journal=Eur. J. Biochem. |volume=207 |issue= 2 |pages= 541–7 |year= 1992 |pmid= 1633809 |doi=
*cite journal | author=Schäfer BW, Wicki R, Engelkamp D, "et al." |title=Isolation of a YAC clone covering a cluster of nine S100 genes on human chromosome 1q21: rationale for a new nomenclature of the S100 calcium-binding protein family. |journal=Genomics |volume=25 |issue= 3 |pages= 638–43 |year= 1995 |pmid= 7759097 |doi=
*cite journal | author=Engelkamp D, Schäfer BW, Mattei MG, "et al." |title=Six S100 genes are clustered on human chromosome 1q21: identification of two genes coding for the two previously unreported calcium-binding proteins S100D and S100E. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=90 |issue= 14 |pages= 6547–51 |year= 1993 |pmid= 8341667 |doi=
*cite journal | author=Gribenko AV, Makhatadze GI |title=Oligomerization and divalent ion binding properties of the S100P protein: a Ca2+/Mg2+-switch model. |journal=J. Mol. Biol. |volume=283 |issue= 3 |pages= 679–94 |year= 1998 |pmid= 9784376 |doi= 10.1006/jmbi.1998.2116
*cite journal | author=Koltzscher M, Gerke V |title=Identification of hydrophobic amino acid residues involved in the formation of S100P homodimers in vivo. |journal=Biochemistry |volume=39 |issue= 31 |pages= 9533–9 |year= 2000 |pmid= 10924150 |doi=
*cite journal | author=Harvell JD, Fulton R, Jones CD, "et al." |title=Composite dendritic cell neoplasm (NOS) and small lymphocytic lymphoma. |journal=Appl. Immunohistochem. Mol. Morphol. |volume=8 |issue= 4 |pages= 322–8 |year= 2001 |pmid= 11127925 |doi=
*cite journal | author=Gribenko AV, Hopper JE, Makhatadze GI |title=Molecular characterization and tissue distribution of a novel member of the S100 family of EF-hand proteins. |journal=Biochemistry |volume=40 |issue= 51 |pages= 15538–48 |year= 2002 |pmid= 11747429 |doi=
*cite journal | author=Gribenko AV, Guzmán-Casado M, Lopez MM, Makhatadze GI |title=Conformational and thermodynamic properties of peptide binding to the human S100P protein. |journal=Protein Sci. |volume=11 |issue= 6 |pages= 1367–75 |year= 2003 |pmid= 12021435 |doi=
*cite journal | author=Filipek A, Jastrzebska B, Nowotny M, Kuznicki J |title=CacyBP/SIP, a calcyclin and Siah-1-interacting protein, binds EF-hand proteins of the S100 family. |journal=J. Biol. Chem. |volume=277 |issue= 32 |pages= 28848–52 |year= 2002 |pmid= 12042313 |doi= 10.1074/jbc.M203602200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Zhang H, Wang G, Ding Y, "et al." |title=The crystal structure at 2A resolution of the Ca2+ -binding protein S100P. |journal=J. Mol. Biol. |volume=325 |issue= 4 |pages= 785–94 |year= 2003 |pmid= 12507480 |doi=
*cite journal | author=Nowotny M, Spiechowicz M, Jastrzebska B, "et al." |title=Calcium-regulated interaction of Sgt1 with S100A6 (calcyclin) and other S100 proteins. |journal=J. Biol. Chem. |volume=278 |issue= 29 |pages= 26923–8 |year= 2003 |pmid= 12746458 |doi= 10.1074/jbc.M211518200
*cite journal | author=Koltzscher M, Neumann C, König S, Gerke V |title=Ca2+-dependent binding and activation of dormant ezrin by dimeric S100P. |journal=Mol. Biol. Cell |volume=14 |issue= 6 |pages= 2372–84 |year= 2004 |pmid= 12808036 |doi= 10.1091/mbc.E02-09-0553
*cite journal | author=Arumugam T, Simeone DM, Schmidt AM, Logsdon CD |title=S100P stimulates cell proliferation and survival via receptor for activated glycation end products (RAGE). |journal=J. Biol. Chem. |volume=279 |issue= 7 |pages= 5059–65 |year= 2004 |pmid= 14617629 |doi= 10.1074/jbc.M310124200
*cite journal | author=Jin G, Wang S, Hu X, "et al." |title=Characterization of the tissue-specific expression of the s100P gene which encodes an EF-hand Ca2+-binding protein. |journal=Mol. Biol. Rep. |volume=30 |issue= 4 |pages= 243–8 |year= 2004 |pmid= 14672411 |doi=
*cite journal | author=Sato N, Fukushima N, Matsubayashi H, Goggins M |title=Identification of maspin and S100P as novel hypomethylation targets in pancreatic cancer using global gene expression profiling. |journal=Oncogene |volume=23 |issue= 8 |pages= 1531–8 |year= 2004 |pmid= 14716296 |doi= 10.1038/sj.onc.1207269
*cite journal | author=Lee YC, Volk DE, Thiviyanathan V, "et al." |title=NMR structure of the Apo-S100P protein. |journal=J. Biomol. NMR |volume=29 |issue= 3 |pages= 399–402 |year= 2005 |pmid= 15213440 |doi= 10.1023/B:JNMR.0000032617.88899.4b

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