CLEC7A

C-type lectin domain family 7, member A, also known as CLEC7A, is a human gene.cite web | title = Entrez Gene: CLEC7A C-type lectin domain family 7, member A| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=64581| accessdate = ]

PBB_Summary
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summary_text = This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. The encoded glycoprotein is a small type II membrane receptor with an extracellular C-type lectin-like domain fold and a cytoplasmic domain with an immunoreceptor tyrosine-based activation motif. It functions as a pattern-recognition receptor that recognizes a variety of beta-1,3-linked and beta-1,6-linked glucans from fungi and plants, and in this way plays a role in innate immune response. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region.cite web | title = Entrez Gene: CLEC7A C-type lectin domain family 7, member A| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=64581| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Drickamer K |title=C-type lectin-like domains. |journal=Curr. Opin. Struct. Biol. |volume=9 |issue= 5 |pages= 585–90 |year= 1999 |pmid= 10508765 |doi=
*cite journal | author=Brown GD |title=Dectin-1: a signalling non-TLR pattern-recognition receptor. |journal=Nat. Rev. Immunol. |volume=6 |issue= 1 |pages= 33–43 |year= 2006 |pmid= 16341139 |doi= 10.1038/nri1745
*cite journal | author=Adams MD, Kerlavage AR, Fleischmann RD, "et al." |title=Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence. |journal=Nature |volume=377 |issue= 6547 Suppl |pages= 3–174 |year= 1995 |pmid= 7566098 |doi=
*cite journal | author=Ariizumi K, Shen GL, Shikano S, "et al." |title=Identification of a novel, dendritic cell-associated molecule, dectin-1, by subtractive cDNA cloning. |journal=J. Biol. Chem. |volume=275 |issue= 26 |pages= 20157–67 |year= 2000 |pmid= 10779524 |doi= 10.1074/jbc.M909512199
*cite journal | author=Yokota K, Takashima A, Bergstresser PR, Ariizumi K |title=Identification of a human homologue of the dendritic cell-associated C-type lectin-1, dectin-1. |journal=Gene |volume=272 |issue= 1-2 |pages= 51–60 |year= 2001 |pmid= 11470510 |doi=
*cite journal | author=Hermanz-Falcón P, Arce I, Roda-Navarro P, Fernández-Ruiz E |title=Cloning of human DECTIN-1, a novel C-type lectin-like receptor gene expressed on dendritic cells. |journal=Immunogenetics |volume=53 |issue= 4 |pages= 288–95 |year= 2001 |pmid= 11491532 |doi=
*cite journal | author=Brown GD, Gordon S |title=Immune recognition. A new receptor for beta-glucans. |journal=Nature |volume=413 |issue= 6851 |pages= 36–7 |year= 2001 |pmid= 11544516 |doi= 10.1038/35092620
*cite journal | author=Willment JA, Gordon S, Brown GD |title=Characterization of the human beta -glucan receptor and its alternatively spliced isoforms. |journal=J. Biol. Chem. |volume=276 |issue= 47 |pages= 43818–23 |year= 2001 |pmid= 11567029 |doi= 10.1074/jbc.M107715200
*cite journal | author=Sobanov Y, Bernreiter A, Derdak S, "et al." |title=A novel cluster of lectin-like receptor genes expressed in monocytic, dendritic and endothelial cells maps close to the NK receptor genes in the human NK gene complex. |journal=Eur. J. Immunol. |volume=31 |issue= 12 |pages= 3493–503 |year= 2002 |pmid= 11745369 |doi=
*cite journal | author=Grünebach F, Weck MM, Reichert J, Brossart P |title=Molecular and functional characterization of human Dectin-1. |journal=Exp. Hematol. |volume=30 |issue= 11 |pages= 1309–15 |year= 2002 |pmid= 12423684 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Ahrén IL, Eriksson E, Egesten A, Riesbeck K |title=Nontypeable Haemophilus influenzae activates human eosinophils through beta-glucan receptors. |journal=Am. J. Respir. Cell Mol. Biol. |volume=29 |issue= 5 |pages= 598–605 |year= 2003 |pmid= 12689921 |doi= 10.1165/rcmb.2002-0138OC
*cite journal | author=Ebner S, Sharon N, Ben-Tal N |title=Evolutionary analysis reveals collective properties and specificity in the C-type lectin and lectin-like domain superfamily. |journal=Proteins |volume=53 |issue= 1 |pages= 44–55 |year= 2003 |pmid= 12945048 |doi= 10.1002/prot.10440
*cite journal | author=Clark HF, Gurney AL, Abaya E, "et al." |title=The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265–70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003
*cite journal | author=Taylor PR, Brown GD, Herre J, "et al." |title=The role of SIGNR1 and the beta-glucan receptor (dectin-1) in the nonopsonic recognition of yeast by specific macrophages. |journal=J. Immunol. |volume=172 |issue= 2 |pages= 1157–62 |year= 2004 |pmid= 14707091 |doi=
*cite journal | author=Mantegazza AR, Barrio MM, Moutel S, "et al." |title=CD63 tetraspanin slows down cell migration and translocates to the endosomal-lysosomal-MIICs route after extracellular stimuli in human immature dendritic cells. |journal=Blood |volume=104 |issue= 4 |pages= 1183–90 |year= 2005 |pmid= 15130945 |doi= 10.1182/blood-2004-01-0104
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=de la Rosa G, Yáñez-Mó M, Samaneigo R, "et al." |title=Regulated recruitment of DC-SIGN to cell-cell contact regions during zymosan-induced human dendritic cell aggregation. |journal=J. Leukoc. Biol. |volume=77 |issue= 5 |pages= 699–709 |year= 2005 |pmid= 15728245 |doi= 10.1189/jlb.0904529
*cite journal | author=Willment JA, Marshall AS, Reid DM, "et al." |title=The human beta-glucan receptor is widely expressed and functionally equivalent to murine Dectin-1 on primary cells. |journal=Eur. J. Immunol. |volume=35 |issue= 5 |pages= 1539–47 |year= 2005 |pmid= 15816015 |doi= 10.1002/eji.200425725

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