Homeobox B5, also known as HOXB5, is a human gene.cite web | title = Entrez Gene: HOXB5 homeobox B5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3215| accessdate = ]

section_title =
summary_text = This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in lung and gut development. Increased expression of this gene is associated with a distinct biologic subset of acute myeloid leukemia (AML) and the occurrence of bronchopulmonary sequestration (BPS) and congenital cystic adenomatoid malformation (CCAM) tissue.cite web | title = Entrez Gene: HOXB5 homeobox B5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3215| accessdate = ]

ee also

* Homeobox


Further reading

citations =
*cite journal | author=Galang CK, Hauser CA |title=Cooperative DNA binding of the highly conserved human Hox 2.1 homeodomain gene product. |journal=New Biol. |volume=4 |issue= 5 |pages= 558–68 |year= 1992 |pmid= 1355360 |doi=
*cite journal | author=Scott MP |title=Vertebrate homeobox gene nomenclature. |journal=Cell |volume=71 |issue= 4 |pages= 551–3 |year= 1992 |pmid= 1358459 |doi=
*cite journal | author=McAlpine PJ, Shows TB |title=Nomenclature for human homeobox genes. |journal=Genomics |volume=7 |issue= 3 |pages= 460 |year= 1990 |pmid= 1973146 |doi=
*cite journal | author=Peverali FA, D'Esposito M, Acampora D, "et al." |title=Expression of HOX homeogenes in human neuroblastoma cell culture lines. |journal=Differentiation |volume=45 |issue= 1 |pages= 61–9 |year= 1991 |pmid= 1981366 |doi=
*cite journal | author=Giampaolo A, Acampora D, Zappavigna V, "et al." |title=Differential expression of human HOX-2 genes along the anterior-posterior axis in embryonic central nervous system. |journal=Differentiation |volume=40 |issue= 3 |pages= 191–7 |year= 1989 |pmid= 2570724 |doi=
*cite journal | author=Acampora D, D'Esposito M, Faiella A, "et al." |title=The human HOX gene family. |journal=Nucleic Acids Res. |volume=17 |issue= 24 |pages= 10385–402 |year= 1990 |pmid= 2574852 |doi=
*cite journal | author=Boncinelli E, Acampora D, Pannese M, "et al." |title=Organization of human class I homeobox genes. |journal=Genome |volume=31 |issue= 2 |pages= 745–56 |year= 1990 |pmid= 2576652 |doi=
*cite journal | author=Rabin M, Ferguson-Smith A, Hart CP, Ruddle FH |title=Cognate homeo-box loci mapped on homologous human and mouse chromosomes. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=83 |issue= 23 |pages= 9104–8 |year= 1987 |pmid= 2878432 |doi=
*cite journal | author=Hart CP, Awgulewitsch A, Fainsod A, "et al." |title=Homeo box gene complex on mouse chromosome 11: molecular cloning, expression in embryogenesis, and homology to a human homeo box locus. |journal=Cell |volume=43 |issue= 1 |pages= 9–18 |year= 1986 |pmid= 3000607 |doi=
*cite journal | author=Xu WM, Gorman PA, Rider SH, "et al." |title=Construction of a genetic map of human chromosome 17 by use of chromosome-mediated gene transfer. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=85 |issue= 22 |pages= 8563–7 |year= 1988 |pmid= 3186746 |doi=
*cite journal | author=Simeone A, Mavilio F, Bottero L, "et al." |title=A human homoeo box gene specifically expressed in spinal cord during embryonic development. |journal=Nature |volume=320 |issue= 6064 |pages= 763–5 |year= 1986 |pmid= 3453105 |doi= 10.1038/320763a0
*cite journal | author=Hauser CA, Joyner AL, Klein RD, "et al." |title=Expression of homologous homeo-box-containing genes in differentiated human teratocarcinoma cells and mouse embryos. |journal=Cell |volume=43 |issue= 1 |pages= 19–28 |year= 1986 |pmid= 4075393 |doi=
*cite journal | author=Levine M, Rubin GM, Tjian R |title=Human DNA sequences homologous to a protein coding region conserved between homeotic genes of Drosophila. |journal=Cell |volume=38 |issue= 3 |pages= 667–73 |year= 1984 |pmid= 6091895 |doi=
*cite journal | author=Galang CK, Hauser CA |title=Cooperative DNA binding of the human HoxB5 (Hox-2.1) protein is under redox regulation in vitro. |journal=Mol. Cell. Biol. |volume=13 |issue= 8 |pages= 4609–17 |year= 1993 |pmid= 8101633 |doi=
*cite journal | author=Apiou F, Flagiello D, Cillo C, "et al." |title=Fine mapping of human HOX gene clusters. |journal=Cytogenet. Cell Genet. |volume=73 |issue= 1-2 |pages= 114–5 |year= 1996 |pmid= 8646877 |doi=
*cite journal | author=Kuliev A, Kukharenko V, Morozov G, "et al." |title=Expression of homebox-containing genes in human preimplantation development and in embryos with chromosomal aneuploidies. |journal=J. Assist. Reprod. Genet. |volume=13 |issue= 2 |pages= 177–81 |year= 1996 |pmid= 8688592 |doi=
*cite journal | author=Sakach M, Safaei R |title=Localization of the HoxB5 protein in the developing CNS of late gestational mouse embryos. |journal=Int. J. Dev. Neurosci. |volume=14 |issue= 5 |pages= 567–73 |year= 1997 |pmid= 8930688 |doi=
*cite journal | author=Archavachotikul K, Ciccone TJ, Chinoy MR, "et al." |title=Thyroid hormone affects embryonic mouse lung branching morphogenesis and cellular differentiation. |journal=Am. J. Physiol. Lung Cell Mol. Physiol. |volume=282 |issue= 3 |pages= L359–69 |year= 2002 |pmid= 11839528 |doi= 10.1152/ajplung.00400.2000
*cite journal | author=Kosaki K, Kosaki R, Suzuki T, "et al." |title=Complete mutation analysis panel of the 39 human HOX genes. |journal=Teratology |volume=65 |issue= 2 |pages= 50–62 |year= 2002 |pmid= 11857506 |doi= 10.1002/tera.10009
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899

External links


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