NCR3

Natural cytotoxicity triggering receptor 3
Identifiers
Symbols	NCR3; 1C7; CD337; LY117; MALS; NKp30
External IDs	OMIM: 611550 HomoloGene: 51827 GeneCards: NCR3 Gene
Gene Ontology Molecular function • receptor activity Cellular component • plasma membrane • integral to plasma membrane Biological process • inflammatory response • immune response • cell recognition • positive regulation of natural killer cell mediated cytotoxicity Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	259197	n/a
Ensembl	ENSG00000204475	n/a
UniProt	O14931	n/a
RefSeq (mRNA)	NM_001145466.1	n/a
RefSeq (protein)	NP_001138938.1	n/a
Location (UCSC)	Chr 6: 31.66 – 31.67 Mb	n/a
PubMed search	[1]	n/a

Natural cytotoxicity triggering receptor 3 is a protein that in humans is encoded by the NCR3 gene.^[1][2][3] NCR3 has also been designated as CD337 (cluster of differentiation 337).

References

1. ^ Nalabolu SR, Shukla H, Nallur G, Parimoo S, Weissman SM (Mar 1997). "Genes in a 220-kb region spanning the TNF cluster in human MHC". Genomics 31 (2): 215–22. doi:10.1006/geno.1996.0034. PMID 8824804. 
2. ^ Sato M, Ohashi J, Tsuchiya N, Tadokoro K, Juji T, Hanaoka K, Tokunaga K, Yabe T (Jan 2002). "Identification of novel single nucleotide substitutions in the NKp30 gene expressed in human natural killer cells". Tissue Antigens 58 (4): 255–8. doi:10.1034/j.1399-0039.2001.580406.x. PMID 11782277. 
3. ^ "Entrez Gene: NCR3 natural cytotoxicity triggering receptor 3". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=259197. 

Further reading

• Djeu JY, Jiang K, Wei S (2002). "A view to a kill: signals triggering cytotoxicity". Clin. Cancer Res. 8 (3): 636–40. PMID 11895890. 
• Holzinger I, de Baey A, Messer G, et al. (1995). "Cloning and genomic characterization of LST1: a new gene in the human TNF region". Immunogenetics 42 (5): 315–22. doi:10.1007/BF00179392. PMID 7590964. 
• de Baey A, Fellerhoff B, Maier S, et al. (1998). "Complex expression pattern of the TNF region gene LST1 through differential regulation, initiation, and alternative splicing". Genomics 45 (3): 591–600. doi:10.1006/geno.1997.4963. PMID 9367684. 
• Neville MJ, Campbell RD (1999). "A new member of the Ig superfamily and a V-ATPase G subunit are among the predicted products of novel genes close to the TNF locus in the human MHC". J. Immunol. 162 (8): 4745–54. PMID 10202016. 
• Pende D, Parolini S, Pessino A, et al. (1999). "Identification and Molecular Characterization of Nkp30, a Novel Triggering Receptor Involved in Natural Cytotoxicity Mediated by Human Natural Killer Cells". J. Exp. Med. 190 (10): 1505–16. doi:10.1084/jem.190.10.1505. PMC 2195691. PMID 10562324. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2195691. 
• Sivakamasundari R, Raghunathan A, Zhang CY, et al. (2000). "Expression and cellular localization of the protein encoded by the 1C7 gene: a recently described component of the MHC". Immunogenetics 51 (8–9): 723–32. doi:10.1007/s002510000192. PMID 10941844. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Le Bouteiller P, Barakonyi A, Giustiniani J, et al. (2003). "Engagement of CD160 receptor by HLA-C is a triggering mechanism used by circulating natural killer (NK) cells to mediate cytotoxicity". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16963–8. doi:10.1073/pnas.012681099. PMC 139252. PMID 12486241. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139252. 
• Augugliaro R, Parolini S, Castriconi R, et al. (2003). "Selective cross-talk among natural cytotoxicity receptors in human natural killer cells". Eur. J. Immunol. 33 (5): 1235–41. doi:10.1002/eji.200323896. PMID 12731048. 
• Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404. 
• Marcenaro E, Augugliaro R, Falco M, et al. (2004). "CD59 is physically and functionally associated with natural cytotoxicity receptors and activates human NK cell-mediated cytotoxicity". Eur. J. Immunol. 33 (12): 3367–76. doi:10.1002/eji.200324425. PMID 14635045. 
• Xie T, Rowen L, Aguado B, et al. (2004). "Analysis of the Gene-Dense Major Histocompatibility Complex Class III Region and Its Comparison to Mouse". Genome Res. 13 (12): 2621–36. doi:10.1101/gr.1736803. PMC 403804. PMID 14656967. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=403804. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Nowbakht P, Ionescu MC, Rohner A, et al. (2005). "Ligands for natural killer cell-activating receptors are expressed upon the maturation of normal myelomonocytic cells but at low levels in acute myeloid leukemias". Blood 105 (9): 3615–22. doi:10.1182/blood-2004-07-2585. PMID 15657183. 
• Poggi A, Massaro AM, Negrini S, et al. (2005). "Tumor-induced apoptosis of human IL-2-activated NK cells: role of natural cytotoxicity receptors". J. Immunol. 174 (5): 2653–60. PMID 15728472. 
• Vitale M, Della Chiesa M, Carlomagno S, et al. (2005). "NK-dependent DC maturation is mediated by TNFalpha and IFNgamma released upon engagement of the NKp30 triggering receptor". Blood 106 (2): 566–71. doi:10.1182/blood-2004-10-4035. PMID 15784725. 
• Warren HS, Jones AL, Freeman C, et al. (2005). "Evidence that the cellular ligand for the human NK cell activation receptor NKp30 is not a heparan sulfate glycosaminoglycan". J. Immunol. 175 (1): 207–12. PMID 15972650. 

External links

• MeSH NCR3+protein,+human

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This membrane protein-related article is a stub. You can help Wikipedia by expanding it.v · Categories: Human proteins Clusters of differentiation Membrane protein stubs Wikimedia Foundation. 2010. Игры ⚽ Нужно сделать НИР? I-Shou University Draria District Look at other dictionaries: NKp30 — Masse/Länge Primärstruktur 183 Aminosäuren …   Deutsch Wikipedia Chandu Borde — Personal information Full name Chandrakant Gulabrao Borde Born 21 July 1934 (1934 07 21) (age 77) Poona, India Batting style Right handed Bowling style Right arm leg break …   Wikipedia Riya Sen — Infobox actor name = Riya Sen caption = Riya Sen at a fashion show. birthname = Riya Dev Varma birthdate = birth date and age|mf=yes|1981|1|24 location = Kolkata, West Bengal, India religion = othername = occupation = Actor, model yearsactive =… …   Wikipedia Remanufacturing — is the process of disassembly and recovery at the module level and, eventually, at the component level. It requires the repair or replacement of worn out or obsolete components and modules. Parts subject to degradation affecting the performance… …   Wikipedia LST1 — Leukocyte specific transcript 1, also known as LST1, is a human gene.cite web | title = Entrez Gene: LST1 leukocyte specific transcript 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=7940| accessdate = ] …   Wikipedia Randhawa Ranjeet — Ranjeet Randhawa is the President and CEO of Medexsoft, Inc. a large multinational US based healthcare software company. He was a former Indian National Champion in track and field who quit track in 1996 to focus on his education and went on to… …   Wikipedia Keshav Puram — is a suburb situated in the north west of Delhi, India. [cite news |title=Booked for receiving stolen property |url=http://www.hindu.com/2005/06/04/stories/2005060417390300.htm |work=The Hindu |date=2005 06 04 |accessdate=2008 07 18 ] It was… …   Wikipedia Charles Cornelius — was an Indian hockey player who represented the Indian national hockey team in the 1973 Hockey World Cup and the 1974 Asian Games in Teheran. Renowned for his abilities, his career was cut short by knee problems. References M. S. Unnikrishnan… …   Wikipedia 18+ © Academic, 2000-2024 Contact us: Technical Support, Advertising Dictionaries export, created on PHP, Joomla, Drupal, WordPress, MODx. Mark and share Search through all dictionaries Translate… Search Internet Share the article and excerpts Direct link … Do a right-click on the link above and select “Copy Link”