ERN1

ERN1

Endoplasmic reticulum to nucleus signalling 1, also known as ERN1, is a human gene.cite web | title = Entrez Gene: ERN1 endoplasmic reticulum to nucleus signalling 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2081| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene is the ER to nucleus signalling 1 protein, a human homologue of the yeast Ire1 gene product. This protein possesses intrinsic kinase activity and an endoribonuclease activity and it is important in altering gene expression as a response to endoplasmic reticulum-based stress signals. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene.cite web | title = Entrez Gene: ERN1 endoplasmic reticulum to nucleus signalling 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2081| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Tirasophon W, Welihinda AA, Kaufman RJ |title=A stress response pathway from the endoplasmic reticulum to the nucleus requires a novel bifunctional protein kinase/endoribonuclease (Ire1p) in mammalian cells. |journal=Genes Dev. |volume=12 |issue= 12 |pages= 1812–24 |year= 1998 |pmid= 9637683 |doi=
*cite journal | author=Katayama T, Imaizumi K, Sato N, "et al." |title=Presenilin-1 mutations downregulate the signalling pathway of the unfolded-protein response. |journal=Nat. Cell Biol. |volume=1 |issue= 8 |pages= 479–85 |year= 2000 |pmid= 10587643 |doi= 10.1038/70265
*cite journal | author=Urano F, Wang X, Bertolotti A, "et al." |title=Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1. |journal=Science |volume=287 |issue= 5453 |pages= 664–6 |year= 2000 |pmid= 10650002 |doi=
*cite journal | author=Dias Neto E, Correa RG, Verjovski-Almeida S, "et al." |title=Shotgun sequencing of the human transcriptome with ORF expressed sequence tags. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 7 |pages= 3491–6 |year= 2000 |pmid= 10737800 |doi=
*cite journal | author=Iwawaki T, Hosoda A, Okuda T, "et al." |title=Translational control by the ER transmembrane kinase/ribonuclease IRE1 under ER stress. |journal=Nat. Cell Biol. |volume=3 |issue= 2 |pages= 158–64 |year= 2001 |pmid= 11175748 |doi= 10.1038/35055065
*cite journal | author=Yoneda T, Imaizumi K, Oono K, "et al." |title=Activation of caspase-12, an endoplastic reticulum (ER) resident caspase, through tumor necrosis factor receptor-associated factor 2-dependent mechanism in response to the ER stress. |journal=J. Biol. Chem. |volume=276 |issue= 17 |pages= 13935–40 |year= 2001 |pmid= 11278723 |doi= 10.1074/jbc.M010677200
*cite journal | author=Lee K, Tirasophon W, Shen X, "et al." |title=IRE1-mediated unconventional mRNA splicing and S2P-mediated ATF6 cleavage merge to regulate XBP1 in signaling the unfolded protein response. |journal=Genes Dev. |volume=16 |issue= 4 |pages= 452–66 |year= 2002 |pmid= 11850408 |doi= 10.1101/gad.964702
*cite journal | author=Liu CY, Wong HN, Schauerte JA, Kaufman RJ |title=The protein kinase/endoribonuclease IRE1alpha that signals the unfolded protein response has a luminal N-terminal ligand-independent dimerization domain. |journal=J. Biol. Chem. |volume=277 |issue= 21 |pages= 18346–56 |year= 2002 |pmid= 11897784 |doi= 10.1074/jbc.M112454200
*cite journal | author=Nishitoh H, Matsuzawa A, Tobiume K, "et al." |title=ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeats. |journal=Genes Dev. |volume=16 |issue= 11 |pages= 1345–55 |year= 2002 |pmid= 12050113 |doi= 10.1101/gad.992302
*cite journal | author=Marcu MG, Doyle M, Bertolotti A, "et al." |title=Heat shock protein 90 modulates the unfolded protein response by stabilizing IRE1alpha. |journal=Mol. Cell. Biol. |volume=22 |issue= 24 |pages= 8506–13 |year= 2003 |pmid= 12446770 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Liu CY, Xu Z, Kaufman RJ |title=Structure and intermolecular interactions of the luminal dimerization domain of human IRE1alpha. |journal=J. Biol. Chem. |volume=278 |issue= 20 |pages= 17680–7 |year= 2003 |pmid= 12637535 |doi= 10.1074/jbc.M300418200
*cite journal | author=Kaneko M, Niinuma Y, Nomura Y |title=Activation signal of nuclear factor-kappa B in response to endoplasmic reticulum stress is transduced via IRE1 and tumor necrosis factor receptor-associated factor 2. |journal=Biol. Pharm. Bull. |volume=26 |issue= 7 |pages= 931–5 |year= 2004 |pmid= 12843613 |doi=
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Shang J, Lehrman MA |title=Discordance of UPR signaling by ATF6 and Ire1p-XBP1 with levels of target transcripts. |journal=Biochem. Biophys. Res. Commun. |volume=317 |issue= 2 |pages= 390–6 |year= 2004 |pmid= 15063770 |doi= 10.1016/j.bbrc.2004.03.058
*cite journal | author=Oono K, Yoneda T, Manabe T, "et al." |title=JAB1 participates in unfolded protein responses by association and dissociation with IRE1. |journal=Neurochem. Int. |volume=45 |issue= 5 |pages= 765–72 |year= 2004 |pmid= 15234121 |doi= 10.1016/j.neuint.2004.01.003
*cite journal | author=Huang ZM, Tan T, Yoshida H, "et al." |title=Activation of hepatitis B virus S promoter by a cell type-restricted IRE1-dependent pathway induced by endoplasmic reticulum stress. |journal=Mol. Cell. Biol. |volume=25 |issue= 17 |pages= 7522–33 |year= 2005 |pmid= 16107700 |doi= 10.1128/MCB.25.17.7522-7533.2005
*cite journal | author=Kimura K, Wakamatsu A, Suzuki Y, "et al." |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406
*cite journal | author=Hetz C, Bernasconi P, Fisher J, "et al." |title=Proapoptotic BAX and BAK modulate the unfolded protein response by a direct interaction with IRE1alpha. |journal=Science |volume=312 |issue= 5773 |pages= 572–6 |year= 2006 |pmid= 16645094 |doi= 10.1126/science.1123480
*cite journal | author=Oikawa D, Tokuda M, Iwawaki T |title=Site-specific cleavage of CD59 mRNA by endoplasmic reticulum-localized ribonuclease, IRE1. |journal=Biochem. Biophys. Res. Commun. |volume=360 |issue= 1 |pages= 122–7 |year= 2007 |pmid= 17585877 |doi= 10.1016/j.bbrc.2007.06.020

PBB_Controls
update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = yes
update_citations = yes


Wikimedia Foundation. 2010.

Игры ⚽ Нужно решить контрольную?

Look at other dictionaries:

  • Autophagy network — consists of enzymes and substrates involved in the degradation of a cell s own components. Network membersThe Autophagy network members (gene name and aliases) as published in the last 500 newest PubMed entries (see below) are depicted… …   Wikipedia

  • Protein kinase domain — Pfam box Symbol = Pkinase Name = Protein kinase domain width = caption = Pfam= PF00069 InterPro= IPR000719 SMART= TyrKc PROSITE = PDOC00629 SCOP = 1apm TCDB = OPM family= OPM protein= 2bcj PDB=PDB3|1ctpE:44 298 PDB3|2erzE:44 298 PDB3|1fotA:87 341 …   Wikipedia

  • dauern — fortdauern; weitergehen (umgangssprachlich); währen; fortbestehen; andauern * * * 1dau|ern [ dau̮ɐn] <itr.; hat: 1. sich über eine bestimmte Zeit erstrecken: die Verhandlung dauerte einige Stunden. Syn.: ↑ …   Universal-Lexikon

  • western — west|ern1 W2S2 Western [ˈwestən US ərn] adj written abbreviation W 1.) in or from the west of a country or area ▪ the western end of the bay ▪ Western Australia 2.) relating to ideas and ways of doing things that come from Europe and the Americas …   Dictionary of contemporary English

  • western — west|ern1 [ westərn ] adjective *** 1. ) in or from the west of a country or place: a western accent the western United States 2. ) in or from the western part of the world, especially Europe and North America: western… …   Usage of the words and phrases in modern English

  • Flöte — 1. Auf der Flöte gewonnen, auf der Trommel von dannen. 2. Besser mit der Flöte regieren, als des Vogtes Peitsche führen. 3. Die Flöte klingt süss, aber weit süsser eine freundliche Rede. 4. Flaüten da sitt huole Pipen, kü ern1 es kain Gelt.… …   Deutsches Sprichwörter-Lexikon

Share the article and excerpts

Direct link
… Do a right-click on the link above
and select “Copy Link”