PLAG1

Pleiomorphic adenoma gene 1, also known as PLAG1, is a human gene.cite web | title = Entrez Gene: PLAG1 pleiomorphic adenoma gene 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5324| accessdate = ]

PBB_Summary
section_title =
summary_text = Pleomorphic adenoma gene 1 encodes a zinc finger protein with 2 putative nuclear localization signals. PLAG1, which is developmentally regulated, has been shown to be consistently rearranged in pleomorphic adenomas of the salivary glands. PLAG1 is activated by the reciprocal chromosomal translocations involving 8q12 in a subset of salivary gland pleomorphic adenomas.cite web | title = Entrez Gene: PLAG1 pleiomorphic adenoma gene 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5324| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Van Dyck F, Declercq J, Braem CV, Van de Ven WJ |title=PLAG1, the prototype of the PLAG gene family: versatility in tumour development (review). |journal=Int. J. Oncol. |volume=30 |issue= 4 |pages= 765–74 |year= 2007 |pmid= 17332914 |doi=
*cite journal | author=Kas K, Voz ML, Röijer E, "et al." |title=Promoter swapping between the genes for a novel zinc finger protein and beta-catenin in pleiomorphic adenomas with t(3;8)(p21;q12) translocations. |journal=Nat. Genet. |volume=15 |issue= 2 |pages= 170–4 |year= 1997 |pmid= 9020842 |doi= 10.1038/ng0297-170
*cite journal | author=Kas K, Röijer E, Voz M, "et al." |title=A 2-Mb YAC contig and physical map covering the chromosome 8q12 breakpoint cluster region in pleomorphic adenomas of the salivary glands. |journal=Genomics |volume=43 |issue= 3 |pages= 349–58 |year= 1997 |pmid= 9268638 |doi= 10.1006/geno.1997.4819
*cite journal | author=Voz ML, Aström AK, Kas K, "et al." |title=The recurrent translocation t(5;8)(p13;q12) in pleomorphic adenomas results in upregulation of PLAG1 gene expression under control of the LIFR promoter. |journal=Oncogene |volume=16 |issue= 11 |pages= 1409–16 |year= 1998 |pmid= 9525740 |doi= 10.1038/sj.onc.1201660
*cite journal | author=Kas K, Voz ML, Hensen K, "et al." |title=Transcriptional activation capacity of the novel PLAG family of zinc finger proteins. |journal=J. Biol. Chem. |volume=273 |issue= 36 |pages= 23026–32 |year= 1998 |pmid= 9722527 |doi=
*cite journal | author=Aström AK, Voz ML, Kas K, "et al." |title=Conserved mechanism of PLAG1 activation in salivary gland tumors with and without chromosome 8q12 abnormalities: identification of SII as a new fusion partner gene. |journal=Cancer Res. |volume=59 |issue= 4 |pages= 918–23 |year= 1999 |pmid= 10029085 |doi=
*cite journal | author=Voz ML, Agten NS, Van de Ven WJ, Kas K |title=PLAG1, the main translocation target in pleomorphic adenoma of the salivary glands, is a positive regulator of IGF-II. |journal=Cancer Res. |volume=60 |issue= 1 |pages= 106–13 |year= 2000 |pmid= 10646861 |doi=
*cite journal | author=Braem CV, Kas K, Meyen E, "et al." |title=Identification of a karyopherin alpha 2 recognition site in PLAG1, which functions as a nuclear localization signal. |journal=J. Biol. Chem. |volume=277 |issue= 22 |pages= 19673–8 |year= 2002 |pmid= 11882654 |doi= 10.1074/jbc.M112112200
*cite journal | author=Hensen K, Van Valckenborgh IC, Kas K, "et al." |title=The tumorigenic diversity of the three PLAG family members is associated with different DNA binding capacities. |journal=Cancer Res. |volume=62 |issue= 5 |pages= 1510–7 |year= 2002 |pmid= 11888928 |doi=
*cite journal | author=Enlund F, Nordkvist A, Sahlin P, "et al." |title=Expression of PLAG1 and HMGIC proteins and fusion transcripts in radiation-associated pleomorphic adenomas. |journal=Int. J. Oncol. |volume=20 |issue= 4 |pages= 713–6 |year= 2002 |pmid= 11894114 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Zatkova A, Rouillard JM, Hartmann W, "et al." |title=Amplification and overexpression of the IGF2 regulator PLAG1 in hepatoblastoma. |journal=Genes Chromosomes Cancer |volume=39 |issue= 2 |pages= 126–37 |year= 2004 |pmid= 14695992 |doi= 10.1002/gcc.10307
*cite journal | author=Van Dyck F, Delvaux EL, Van de Ven WJ, Chavez MV |title=Repression of the Transactivating Capacity of the Oncoprotein PLAG1 by SUMOylation. |journal=J. Biol. Chem. |volume=279 |issue= 34 |pages= 36121–31 |year= 2005 |pmid= 15208321 |doi= 10.1074/jbc.M401753200
*cite journal | author=Colland F, Jacq X, Trouplin V, "et al." |title=Functional proteomics mapping of a human signaling pathway. |journal=Genome Res. |volume=14 |issue= 7 |pages= 1324–32 |year= 2004 |pmid= 15231748 |doi= 10.1101/gr.2334104
*cite journal | author=Tsang YT, Chang YM, Lu X, "et al." |title=Amplification of MGC2177, PLAG1, PSMC6P, and LYN in a malignant mixed tumor of salivary gland detected by cDNA microarray with tyramide signal amplification. |journal=Cancer Genet. Cytogenet. |volume=152 |issue= 2 |pages= 124–8 |year= 2004 |pmid= 15262430 |doi= 10.1016/j.cancergencyto.2003.12.001
*cite journal | author=Landrette SF, Kuo YH, Hensen K, "et al." |title=Plag1 and Plagl2 are oncogenes that induce acute myeloid leukemia in cooperation with Cbfb-MYH11. |journal=Blood |volume=105 |issue= 7 |pages= 2900–7 |year= 2005 |pmid= 15585652 |doi= 10.1182/blood-2004-09-3630
*cite journal | author=Morerio C, Rapella A, Rosanda C, "et al." |title=PLAG1-HAS2 fusion in lipoblastoma with masked 8q intrachromosomal rearrangement. |journal=Cancer Genet. Cytogenet. |volume=156 |issue= 2 |pages= 183–4 |year= 2005 |pmid= 15642402 |doi= 10.1016/j.cancergencyto.2004.04.017
*cite journal | author=Martins C, Fonseca I, Roque L, "et al." |title=PLAG1 gene alterations in salivary gland pleomorphic adenoma and carcinoma ex-pleomorphic adenoma: a combined study using chromosome banding, in situ hybridization and immunocytochemistry. |journal=Mod. Pathol. |volume=18 |issue= 8 |pages= 1048–55 |year= 2005 |pmid= 15920557 |doi= 10.1038/modpathol.3800386
*cite journal | author=Declercq J, Van Dyck F, Braem CV, "et al." |title=Salivary gland tumors in transgenic mice with targeted PLAG1 proto-oncogene overexpression. |journal=Cancer Res. |volume=65 |issue= 11 |pages= 4544–53 |year= 2005 |pmid= 15930271 |doi= 10.1158/0008-5472.CAN-04-4041
*cite journal | author=Zhao X, Ren W, Yang W, "et al." |title=Wnt pathway is involved in pleomorphic adenomas induced by overexpression of PLAG1 in transgenic mice. |journal=Int. J. Cancer |volume=118 |issue= 3 |pages= 643–8 |year= 2006 |pmid= 16108035 |doi= 10.1002/ijc.21400

External links

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