E2F5

E2F transcription factor 5, p130-binding, also known as E2F5, is a human gene.cite web | title = Entrez Gene: E2F5 E2F transcription factor 5, p130-binding| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1875| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionarily conserved domains that are present in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein is differentially phosphorylated and is expressed in a wide variety of human tissues. It has higher identity to E2F4 than to other family members. Both this protein and E2F4 interact with tumor suppressor proteins p130 and p107, but not with pRB. Alternative splicing results in multiple variants encoding different isoforms.cite web | title = Entrez Gene: E2F5 E2F transcription factor 5, p130-binding| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1875| accessdate = ]

ee also

* E2F

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Hijmans EM, Voorhoeve PM, Beijersbergen RL, "et al." |title=E2F-5, a new E2F family member that interacts with p130 in vivo. |journal=Mol. Cell. Biol. |volume=15 |issue= 6 |pages= 3082–9 |year= 1995 |pmid= 7760804 |doi=
*cite journal | author=Sardet C, Vidal M, Cobrinik D, "et al." |title=E2F-4 and E2F-5, two members of the E2F family, are expressed in the early phases of the cell cycle. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=92 |issue= 6 |pages= 2403–7 |year= 1995 |pmid= 7892279 |doi=
*cite journal | author=Ginsberg D, Vairo G, Chittenden T, "et al." |title=E2F-4, a new member of the E2F transcription factor family, interacts with p107. |journal=Genes Dev. |volume=8 |issue= 22 |pages= 2665–79 |year= 1994 |pmid= 7958924 |doi=
*cite journal | author=Beijersbergen RL, Kerkhoven RM, Zhu L, "et al." |title=E2F-4, a new member of the E2F gene family, has oncogenic activity and associates with p107 in vivo. |journal=Genes Dev. |volume=8 |issue= 22 |pages= 2680–90 |year= 1994 |pmid= 7958925 |doi=
*cite journal | author=Itoh A, Levinson SF, Morita T, "et al." |title=Structural characterization and specificity of expression of E2F-5: a new member of the E2F family of transcription factors. |journal=Cell. Mol. Biol. Res. |volume=41 |issue= 3 |pages= 147–54 |year= 1996 |pmid= 8589754 |doi=
*cite journal | author=Lindeman GJ, Gaubatz S, Livingston DM, Ginsberg D |title=The subcellular localization of E2F-4 is cell-cycle dependent. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 10 |pages= 5095–100 |year= 1997 |pmid= 9144196 |doi=
*cite journal | author=Vaishnav YN, Vaishnav MY, Pant V |title=The molecular and functional characterization of E2F-5 transcription factor. |journal=Biochem. Biophys. Res. Commun. |volume=242 |issue= 3 |pages= 586–92 |year= 1998 |pmid= 9464260 |doi= 10.1006/bbrc.1997.8010
*cite journal | author=Morris L, Allen KE, La Thangue NB |title=Regulation of E2F transcription by cyclin E-Cdk2 kinase mediated through p300/CBP co-activators. |journal=Nat. Cell Biol. |volume=2 |issue= 4 |pages= 232–9 |year= 2000 |pmid= 10783242 |doi= 10.1038/35008660
*cite journal | author=Gaubatz S, Lindeman GJ, Ishida S, "et al." |title=E2F4 and E2F5 play an essential role in pocket protein-mediated G1 control. |journal=Mol. Cell |volume=6 |issue= 3 |pages= 729–35 |year= 2000 |pmid= 11030352 |doi=
*cite journal | author=D'Souza SJ, Pajak A, Balazsi K, Dagnino L |title=Ca2+ and BMP-6 signaling regulate E2F during epidermal keratinocyte differentiation. |journal=J. Biol. Chem. |volume=276 |issue= 26 |pages= 23531–8 |year= 2001 |pmid= 11319226 |doi= 10.1074/jbc.M100780200
*cite journal | author=Chestukhin A, Litovchick L, Rudich K, DeCaprio JA |title=Nucleocytoplasmic shuttling of p130/RBL2: novel regulatory mechanism. |journal=Mol. Cell. Biol. |volume=22 |issue= 2 |pages= 453–68 |year= 2002 |pmid= 11756542 |doi=
*cite journal | author=Apostolova MD, Ivanova IA, Dagnino C, "et al." |title=Active nuclear import and export pathways regulate E2F-5 subcellular localization. |journal=J. Biol. Chem. |volume=277 |issue= 37 |pages= 34471–9 |year= 2002 |pmid= 12089160 |doi= 10.1074/jbc.M205827200
*cite journal | author=Chen CR, Kang Y, Siegel PM, Massagué J |title=E2F4/5 and p107 as Smad cofactors linking the TGFbeta receptor to c-myc repression. |journal=Cell |volume=110 |issue= 1 |pages= 19–32 |year= 2002 |pmid= 12150994 |doi=
*cite journal | author=Macaluso M, Cinti C, Russo G, "et al." |title=pRb2/p130-E2F4/5-HDAC1-SUV39H1-p300 and pRb2/p130-E2F4/5-HDAC1-SUV39H1-DNMT1 multimolecular complexes mediate the transcription of estrogen receptor-alpha in breast cancer. |journal=Oncogene |volume=22 |issue= 23 |pages= 3511–7 |year= 2003 |pmid= 12789259 |doi= 10.1038/sj.onc.1206578
*cite journal | author=Ohtani N, Brennan P, Gaubatz S, "et al." |title=Epstein-Barr virus LMP1 blocks p16INK4a-RB pathway by promoting nuclear export of E2F4/5. |journal=J. Cell Biol. |volume=162 |issue= 2 |pages= 173–83 |year= 2003 |pmid= 12860972 |doi= 10.1083/jcb.200302085
*cite journal | author=Brandenberger R, Wei H, Zhang S, "et al." |title=Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. |journal=Nat. Biotechnol. |volume=22 |issue= 6 |pages= 707–16 |year= 2005 |pmid= 15146197 |doi= 10.1038/nbt971
*cite journal | author=Jiang Y, Saavedra HI, Holloway MP, "et al." |title=Aberrant regulation of survivin by the RB/E2F family of proteins. |journal=J. Biol. Chem. |volume=279 |issue= 39 |pages= 40511–20 |year= 2004 |pmid= 15271987 |doi= 10.1074/jbc.M404496200
*cite journal | author=Suzuki Y, Yamashita R, Shirota M, "et al." |title=Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. |journal=Genome Res. |volume=14 |issue= 9 |pages= 1711–8 |year= 2004 |pmid= 15342556 |doi= 10.1101/gr.2435604
*cite journal | author=Joshi B, Ordonez-Ercan D, Dasgupta P, Chellappan S |title=Induction of human metallothionein 1G promoter by VEGF and heavy metals: differential involvement of E2F and metal transcription factors. |journal=Oncogene |volume=24 |issue= 13 |pages= 2204–17 |year= 2005 |pmid= 15735762 |doi= 10.1038/sj.onc.1208206
*cite journal | author=Swetloff A, Ferretti P |title=Changes in E2F5 intracellular localization in mouse and human choroid plexus epithelium with development. |journal=Int. J. Dev. Biol. |volume=49 |issue= 7 |pages= 859–65 |year= 2006 |pmid= 16172982 |doi= 10.1387/ijdb.051996as

External links

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