HNRPAB

Heterogeneous nuclear ribonucleoprotein A/B, also known as HNRPAB, is a human gene.cite web | title = Entrez Gene: HNRPAB heterogeneous nuclear ribonucleoprotein A/B| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3182| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are produced by RNA polymerase II and are components of the heterogeneous nuclear RNA (hnRNA) complexes. They are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene, which binds to one of the components of the multiprotein editosome complex, has two repeats of quasi-RRM (RNA recognition motif) domains that bind to RNAs. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene.cite web | title = Entrez Gene: HNRPAB heterogeneous nuclear ribonucleoprotein A/B| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3182| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Khan FA, Jaiswal AK, Szer W |title=Cloning and sequence analysis of a human type A/B hnRNP protein. |journal=FEBS Lett. |volume=290 |issue= 1-2 |pages= 159–61 |year= 1991 |pmid= 1717314 |doi=
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=Gress TM, Müller-Pillasch F, Geng M, "et al." |title=A pancreatic cancer-specific expression profile. |journal=Oncogene |volume=13 |issue= 8 |pages= 1819–30 |year= 1996 |pmid= 8895530 |doi=
*cite journal | author=Lau PP, Zhu HJ, Nakamuta M, Chan L |title=Cloning of an Apobec-1-binding protein that also interacts with apolipoprotein B mRNA and evidence for its involvement in RNA editing. |journal=J. Biol. Chem. |volume=272 |issue= 3 |pages= 1452–5 |year= 1997 |pmid= 8999813 |doi=
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=
*cite journal | author=Hay DC, Kemp GD, Dargemont C, Hay RT |title=Interaction between hnRNPA1 and IkappaBalpha is required for maximal activation of NF-kappaB-dependent transcription. |journal=Mol. Cell. Biol. |volume=21 |issue= 10 |pages= 3482–90 |year= 2001 |pmid= 11313474 |doi= 10.1128/MCB.21.10.3482-3490.2001
*cite journal | author=Lau PP, Chang BH, Chan L |title=Two-hybrid cloning identifies an RNA-binding protein, GRY-RBP, as a component of apobec-1 editosome. |journal=Biochem. Biophys. Res. Commun. |volume=282 |issue= 4 |pages= 977–83 |year= 2001 |pmid= 11352648 |doi= 10.1006/bbrc.2001.4679
*cite journal | author=Gallouzi IE, Brennan CM, Steitz JA |title=Protein ligands mediate the CRM1-dependent export of HuR in response to heat shock. |journal=RNA |volume=7 |issue= 9 |pages= 1348–61 |year= 2001 |pmid= 11565755 |doi=
*cite journal | author=Andersen JS, Lyon CE, Fox AH, "et al." |title=Directed proteomic analysis of the human nucleolus. |journal=Curr. Biol. |volume=12 |issue= 1 |pages= 1–11 |year= 2002 |pmid= 11790298 |doi=
*cite journal | author=Percipalle P, Jonsson A, Nashchekin D, "et al." |title=Nuclear actin is associated with a specific subset of hnRNP A/B-type proteins. |journal=Nucleic Acids Res. |volume=30 |issue= 8 |pages= 1725–34 |year= 2002 |pmid= 11937625 |doi=
*cite journal | author=Angenstein F, Evans AM, Settlage RE, "et al." |title=A receptor for activated C kinase is part of messenger ribonucleoprotein complexes associated with polyA-mRNAs in neurons. |journal=J. Neurosci. |volume=22 |issue= 20 |pages= 8827–37 |year= 2002 |pmid= 12388589 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Fomenkov A, Huang YP, Topaloglu O, "et al." |title=P63 alpha mutations lead to aberrant splicing of keratinocyte growth factor receptor in the Hay-Wells syndrome. |journal=J. Biol. Chem. |volume=278 |issue= 26 |pages= 23906–14 |year= 2003 |pmid= 12692135 |doi= 10.1074/jbc.M300746200
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Zhang S, Schlott B, Görlach M, Grosse F |title=DNA-dependent protein kinase (DNA-PK) phosphorylates nuclear DNA helicase II/RNA helicase A and hnRNP proteins in an RNA-dependent manner. |journal=Nucleic Acids Res. |volume=32 |issue= 1 |pages= 1–10 |year= 2004 |pmid= 14704337 |doi= 10.1093/nar/gkg933
*cite journal | author=Gao C, Guo H, Wei J, "et al." |title=S-nitrosylation of heterogeneous nuclear ribonucleoprotein A/B regulates osteopontin transcription in endotoxin-stimulated murine macrophages. |journal=J. Biol. Chem. |volume=279 |issue= 12 |pages= 11236–43 |year= 2004 |pmid= 14722087 |doi= 10.1074/jbc.M313385200
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Ong SE, Mittler G, Mann M |title=Identifying and quantifying in vivo methylation sites by heavy methyl SILAC. |journal=Nat. Methods |volume=1 |issue= 2 |pages= 119–26 |year= 2005 |pmid= 15782174 |doi= 10.1038/nmeth715
*cite journal | author=Beausoleil SA, Villén J, Gerber SA, "et al." |title=A probability-based approach for high-throughput protein phosphorylation analysis and site localization. |journal=Nat. Biotechnol. |volume=24 |issue= 10 |pages= 1285–92 |year= 2006 |pmid= 16964243 |doi= 10.1038/nbt1240
*cite journal | author=Ewing RM, Chu P, Elisma F, "et al." |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue= |pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134

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