KCNK2

KCNK2

Potassium channel, subfamily K, member 2, also known as KCNK2, is a human gene.cite web | title = Entrez Gene: KCNK2 potassium channel, subfamily K, member 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3776| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes one of the members of the two-pore-domain background potassium channel protein family. This type of potassium channel is formed by two homodimers that create a channel that leaks potassium out of the cell to control resting membrane potential. The channel can be opened, however, by certain anesthetics, membrane stretching, intracellular acidosis, and heat. Three transcript variants encoding different isoforms have been found for this gene.cite web | title = Entrez Gene: KCNK2 potassium channel, subfamily K, member 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3776| accessdate = ]

ee also

* Tandem pore domain potassium channel

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Goldstein SA, Bockenhauer D, O'Kelly I, Zilberberg N |title=Potassium leak channels and the KCNK family of two-P-domain subunits. |journal=Nat. Rev. Neurosci. |volume=2 |issue= 3 |pages= 175–84 |year= 2001 |pmid= 11256078 |doi=
*cite journal | author=Goldstein SA, Bayliss DA, Kim D, "et al." |title=International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels. |journal=Pharmacol. Rev. |volume=57 |issue= 4 |pages= 527–40 |year= 2006 |pmid= 16382106 |doi= 10.1124/pr.57.4.12
*cite journal | author=Honoré E |title=The neuronal background K2P channels: focus on TREK1. |journal=Nat. Rev. Neurosci. |volume=8 |issue= 4 |pages= 251–61 |year= 2007 |pmid= 17375039 |doi= 10.1038/nrn2117
*cite journal | author=Fink M, Duprat F, Lesage F, "et al." |title=Cloning, functional expression and brain localization of a novel unconventional outward rectifier K+ channel. |journal=EMBO J. |volume=15 |issue= 24 |pages= 6854–62 |year= 1997 |pmid= 9003761 |doi=
*cite journal | author=Lesage F, Lazdunski M |title=Mapping of human potassium channel genes TREK-1 (KCNK2) and TASK (KCNK3) to chromosomes 1q41 and 2p23. |journal=Genomics |volume=51 |issue= 3 |pages= 478–9 |year= 1998 |pmid= 9721223 |doi= 10.1006/geno.1998.5397
*cite journal | author=Patel AJ, Honoré E, Lesage F, "et al." |title=Inhalational anesthetics activate two-pore-domain background K+ channels. |journal=Nat. Neurosci. |volume=2 |issue= 5 |pages= 422–6 |year= 1999 |pmid= 10321245 |doi= 10.1038/8084
*cite journal | author=Meadows HJ, Benham CD, Cairns W, "et al." |title=Cloning, localisation and functional expression of the human orthologue of the TREK-1 potassium channel. |journal=Pflugers Arch. |volume=439 |issue= 6 |pages= 714–22 |year= 2000 |pmid= 10784345 |doi=
*cite journal | author=Maylie J, Adelman JP |title=Beam me up, Scottie! TREK channels swing both ways. |journal=Nat. Neurosci. |volume=4 |issue= 5 |pages= 457–8 |year= 2001 |pmid= 11319549 |doi= 10.1038/87402
*cite journal | author=Bockenhauer D, Zilberberg N, Goldstein SA |title=KCNK2: reversible conversion of a hippocampal potassium leak into a voltage-dependent channel. |journal=Nat. Neurosci. |volume=4 |issue= 5 |pages= 486–91 |year= 2001 |pmid= 11319556 |doi= 10.1038/87434
*cite journal | author=Enyeart JJ, Xu L, Danthi S, Enyeart JA |title=An ACTH- and ATP-regulated background K+ channel in adrenocortical cells is TREK-1. |journal=J. Biol. Chem. |volume=277 |issue= 51 |pages= 49186–99 |year= 2003 |pmid= 12368289 |doi= 10.1074/jbc.M207233200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Imabayashi H, Mori T, Gojo S, "et al." |title=Redifferentiation of dedifferentiated chondrocytes and chondrogenesis of human bone marrow stromal cells via chondrosphere formation with expression profiling by large-scale cDNA analysis. |journal=Exp. Cell Res. |volume=288 |issue= 1 |pages= 35–50 |year= 2003 |pmid= 12878157 |doi=
*cite journal | author=Miller P, Peers C, Kemp PJ |title=Polymodal regulation of hTREK1 by pH, arachidonic acid, and hypoxia: physiological impact in acidosis and alkalosis. |journal=Am. J. Physiol., Cell Physiol. |volume=286 |issue= 2 |pages= C272–82 |year= 2004 |pmid= 14522822 |doi= 10.1152/ajpcell.00334.2003
*cite journal | author=Fu GK, Wang JT, Yang J, "et al." |title=Circular rapid amplification of cDNA ends for high-throughput extension cloning of partial genes. |journal=Genomics |volume=84 |issue= 1 |pages= 205–10 |year= 2005 |pmid= 15203218 |doi= 10.1016/j.ygeno.2004.01.011
*cite journal | author=Kennard LE, Chumbley JR, Ranatunga KM, "et al." |title=Inhibition of the human two-pore domain potassium channel, TREK-1, by fluoxetine and its metabolite norfluoxetine. |journal=Br. J. Pharmacol. |volume=144 |issue= 6 |pages= 821–9 |year= 2005 |pmid= 15685212 |doi= 10.1038/sj.bjp.0706068
*cite journal | author=Miller P, Kemp PJ, Peers C |title=Structural requirements for O2 sensing by the human tandem-P domain channel, hTREK1. |journal=Biochem. Biophys. Res. Commun. |volume=331 |issue= 4 |pages= 1253–6 |year= 2005 |pmid= 15883010 |doi= 10.1016/j.bbrc.2005.04.042
*cite journal | author=Murbartián J, Lei Q, Sando JJ, Bayliss DA |title=Sequential phosphorylation mediates receptor- and kinase-induced inhibition of TREK-1 background potassium channels. |journal=J. Biol. Chem. |volume=280 |issue= 34 |pages= 30175–84 |year= 2005 |pmid= 16006563 |doi= 10.1074/jbc.M503862200
*cite journal | author=Hughes S, Magnay J, Foreman M, "et al." |title=Expression of the mechanosensitive 2PK+ channel TREK-1 in human osteoblasts. |journal=J. Cell. Physiol. |volume=206 |issue= 3 |pages= 738–48 |year= 2006 |pmid= 16250016 |doi= 10.1002/jcp.20536
*cite journal | author=Kimura K, Wakamatsu A, Suzuki Y, "et al." |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406

External links

*

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