ATP2A3

ATP2A3

ATPase, Ca++ transporting, ubiquitous, also known as ATP2A3, is a human gene.cite web | title = Entrez Gene: ATP2A3 ATPase, Ca++ transporting, ubiquitous| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=489| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes one of the SERCA Ca(2+)-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of muscle cells. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen, and is involved in calcium sequestration associated with muscular excitation and contraction. Alternative splicing results in multiple transcript variants encoding different isoforms.cite web | title = Entrez Gene: ATP2A3 ATPase, Ca++ transporting, ubiquitous| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=489| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Wuytack F, Papp B, Verboomen H, "et al." |title=A sarco/endoplasmic reticulum Ca(2+)-ATPase 3-type Ca2+ pump is expressed in platelets, in lymphoid cells, and in mast cells. |journal=J. Biol. Chem. |volume=269 |issue= 2 |pages= 1410–6 |year= 1994 |pmid= 8288608 |doi=
*cite journal | author=Dode L, Wuytack F, Kools PF, "et al." |title=cDNA cloning, expression and chromosomal localization of the human sarco/endoplasmic reticulum Ca(2+)-ATPase 3 gene. |journal=Biochem. J. |volume=318 ( Pt 2) |issue= |pages= 689–99 |year= 1996 |pmid= 8809064 |doi=
*cite journal | author=Dode L, De Greef C, Mountian I, "et al." |title=Structure of the human sarco/endoplasmic reticulum Ca2+-ATPase 3 gene. Promoter analysis and alternative splicing of the SERCA3 pre-mRNA. |journal=J. Biol. Chem. |volume=273 |issue= 22 |pages= 13982–94 |year= 1998 |pmid= 9593748 |doi=
*cite journal | author=Poch E, Leach S, Snape S, "et al." |title=Functional characterization of alternatively spliced human SERCA3 transcripts. |journal=Am. J. Physiol. |volume=275 |issue= 6 Pt 1 |pages= C1449–58 |year= 1999 |pmid= 9843705 |doi=
*cite journal | author=Martin V, Bredoux R, Corvazier E, "et al." |title=Three novel sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) 3 isoforms. Expression, regulation, and function of the membranes of the SERCA3 family. |journal=J. Biol. Chem. |volume=277 |issue= 27 |pages= 24442–52 |year= 2002 |pmid= 11956212 |doi= 10.1074/jbc.M202011200
*cite journal | author=Gélébart P, Kovács T, Brouland JP, "et al." |title=Expression of endomembrane calcium pumps in colon and gastric cancer cells. Induction of SERCA3 expression during differentiation. |journal=J. Biol. Chem. |volume=277 |issue= 29 |pages= 26310–20 |year= 2002 |pmid= 11986315 |doi= 10.1074/jbc.M201747200
*cite journal | author=Dode L, Vilsen B, Van Baelen K, "et al." |title=Dissection of the functional differences between sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA) 1 and 3 isoforms by steady-state and transient kinetic analyses. |journal=J. Biol. Chem. |volume=277 |issue= 47 |pages= 45579–91 |year= 2003 |pmid= 12207029 |doi= 10.1074/jbc.M207778200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Houston R |title=Longitudinal sections of unfixed muscle. |journal=Biotechnic & histochemistry : official publication of the Biological Stain Commission |volume=77 |issue= 4 |pages= 229–30 |year= 2003 |pmid= 12503734 |doi=
*cite journal | author=Borge PD, Wolf BA |title=Insulin receptor substrate 1 regulation of sarco-endoplasmic reticulum calcium ATPase 3 in insulin-secreting beta-cells. |journal=J. Biol. Chem. |volume=278 |issue= 13 |pages= 11359–68 |year= 2003 |pmid= 12524443 |doi= 10.1074/jbc.M209521200
*cite journal | author=Chandrasekera CP, Lytton J |title=Inhibition of human SERCA3 by PL/IM430. Molecular analysis of the interaction. |journal=J. Biol. Chem. |volume=278 |issue= 14 |pages= 12482–8 |year= 2003 |pmid= 12540840 |doi= 10.1074/jbc.M212745200
*cite journal | author=Gevaert K, Goethals M, Martens L, "et al." |title=Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. |journal=Nat. Biotechnol. |volume=21 |issue= 5 |pages= 566–9 |year= 2004 |pmid= 12665801 |doi= 10.1038/nbt810
*cite journal | author=Bobe R, Bredoux R, Corvazier E, "et al." |title=Identification, expression, function, and localization of a novel (sixth) isoform of the human sarco/endoplasmic reticulum Ca2+ATPase 3 gene. |journal=J. Biol. Chem. |volume=279 |issue= 23 |pages= 24297–306 |year= 2004 |pmid= 15028735 |doi= 10.1074/jbc.M314286200
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Brouland JP, Gélébart P, Kovàcs T, "et al." |title=The loss of sarco/endoplasmic reticulum calcium transport ATPase 3 expression is an early event during the multistep process of colon carcinogenesis. |journal=Am. J. Pathol. |volume=167 |issue= 1 |pages= 233–42 |year= 2005 |pmid= 15972967 |doi=
*cite journal | author=Hadri L, Pavoine C, Lipskaia L, "et al." |title=Transcription of the sarcoplasmic/endoplasmic reticulum Ca2+-ATPase type 3 gene, ATP2A3, is regulated by the calcineurin/NFAT pathway in endothelial cells. |journal=Biochem. J. |volume=394 |issue= Pt 1 |pages= 27–33 |year= 2006 |pmid= 16250893 |doi= 10.1042/BJ20051387
*cite journal | author=Wootton LL, Michelangeli F |title=The effects of the phenylalanine 256 to valine mutation on the sensitivity of sarcoplasmic/endoplasmic reticulum Ca2+ ATPase (SERCA) Ca2+ pump isoforms 1, 2, and 3 to thapsigargin and other inhibitors. |journal=J. Biol. Chem. |volume=281 |issue= 11 |pages= 6970–6 |year= 2006 |pmid= 16410239 |doi= 10.1074/jbc.M510978200
*cite journal | author=Chaâbane C, Corvazier E, Bredoux R, "et al." |title=Sarco/endoplasmic reticulum Ca2+ATPase type 3 isoforms (SERCA3b and SERCA3f): distinct roles in cell adhesion and ER stress. |journal=Biochem. Biophys. Res. Commun. |volume=345 |issue= 4 |pages= 1377–85 |year= 2006 |pmid= 16725111 |doi= 10.1016/j.bbrc.2006.05.054
*cite journal | author=Bredoux R, Corvazier E, Dally S, "et al." |title=Human platelet Ca2+-ATPases: new markers of cell differentiation as illustrated in idiopathic scoliosis. |journal=Platelets |volume=17 |issue= 6 |pages= 421–33 |year= 2006 |pmid= 16973504 |doi= 10.1080/09537100600758719
*cite journal | author=Ewing RM, Chu P, Elisma F, "et al." |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue= |pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134

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