NDN (gene)

Necdin homolog (mouse)
Identifiers
Symbols	NDN; HsT16328; PWCR
External IDs	OMIM: 602117 MGI: 97290 HomoloGene: 20559 GeneCards: NDN Gene
Gene Ontology Molecular function • DNA binding • protein binding • gamma-tubulin binding Cellular component • nucleus • cytoplasm • centrosome • cytosol • cell projection • perikaryon Biological process • neuron migration • respiratory system process • regulation of transcription, DNA-dependent • nervous system development • axonal fasciculation • central nervous system development • negative regulation of cell proliferation • glial cell migration • post-embryonic development • sensory perception of pain • regulation of growth • nerve growth factor receptor signaling pathway • neuron development • axon extension involved in development • multicellular organismal homeostasis • genetic imprinting Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4692	17984
Ensembl	ENSG00000182636	ENSMUSG00000033585
UniProt	Q99608	Q8C5K8
RefSeq (mRNA)	NM_002487	NM_010882.3
RefSeq (protein)	NP_002478	NP_035012.2
Location (UCSC)	Chr 15: 23.93 – 23.93 Mb	Chr 7: 69.49 – 69.49 Mb
PubMed search	[1]	[2]

Necdin is a protein that in humans is encoded by the NDN gene.^[1][2]

This intronless gene is located in the Prader-Willi syndrome (PWS) deletion region. It is an imprinted gene and is expressed exclusively from the paternal allele. Studies in mice suggest that the protein encoded by this gene may suppress growth in postmitotic neurons.^[2]

Interactions

NDN (gene) has been shown to interact with NUCB2,^[3] E2F1,^[4][5] IL1A,^[6] Low affinity nerve growth factor receptor,^[5][7][8] P53^[9] and HNRNPU.^[10]

References

1. ^ MacDonald HR, Wevrick R (Jan 1998). "The necdin gene is deleted in Prader-Willi syndrome and is imprinted in human and mouse". Hum Mol Genet 6 (11): 1873–8. doi:10.1093/hmg/6.11.1873. PMID 9302265. 
2. ^ ^{a b} "Entrez Gene: NDN necdin homolog (mouse)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4692. 
3. ^ Taniguchi, N; Taniura H, Niinobe M, Takayama C, Tominaga-Yoshino K, Ogura A, Yoshikawa K (Oct. 2000). "The postmitotic growth suppressor necdin interacts with a calcium-binding protein (NEFA) in neuronal cytoplasm". J. Biol. Chem. (UNITED STATES) 275 (41): 31674–81. doi:10.1074/jbc.M005103200. ISSN 0021-9258. PMID 10915798. 
4. ^ Taniura, H; Taniguchi N, Hara M, Yoshikawa K (Jan. 1998). "Necdin, a postmitotic neuron-specific growth suppressor, interacts with viral transforming proteins and cellular transcription factor E2F1". J. Biol. Chem. (UNITED STATES) 273 (2): 720–8. doi:10.1074/jbc.273.2.720. ISSN 0021-9258. PMID 9422723. 
5. ^ ^{a b} Kuwako, Ken-ichiro; Taniura Hideo, Yoshikawa Kazuaki (Jan. 2004). "Necdin-related MAGE proteins differentially interact with the E2F1 transcription factor and the p75 neurotrophin receptor". J. Biol. Chem. (United States) 279 (3): 1703–12. doi:10.1074/jbc.M308454200. ISSN 0021-9258. PMID 14593116. 
6. ^ Hu, Bo; Wang Shuhui, Zhang Yingze, Feghali Carol A, Dingman Jeffrey R, Wright Timothy M (Aug. 2003). "A nuclear target for interleukin-1alpha: interaction with the growth suppressor necdin modulates proliferation and collagen expression". Proc. Natl. Acad. Sci. U.S.A. (United States) 100 (17): 10008–13. doi:10.1073/pnas.1737765100. ISSN 0027-8424. PMC 187743. PMID 12913118. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=187743. 
7. ^ Bronfman, Francisca C; Tcherpakov Marianna, Jovin Thomas M, Fainzilber Mike (Apr. 2003). "Ligand-induced internalization of the p75 neurotrophin receptor: a slow route to the signaling endosome". J. Neurosci. (United States) 23 (8): 3209–20. PMID 12716928. 
8. ^ Tcherpakov, Marianna; Bronfman Francisca C, Conticello Silvestro G, Vaskovsky Anna, Levy Zehava, Niinobe Michio, Yoshikawa Kazuaki, Arenas Ernest, Fainzilber Mike (Dec. 2002). "The p75 neurotrophin receptor interacts with multiple MAGE proteins". J. Biol. Chem. (United States) 277 (51): 49101–4. doi:10.1074/jbc.C200533200. ISSN 0021-9258. PMID 12414813. 
9. ^ Taniura, H; Matsumoto K, Yoshikawa K (Jun. 1999). "Physical and functional interactions of neuronal growth suppressor necdin with p53". J. Biol. Chem. (UNITED STATES) 274 (23): 16242–8. doi:10.1074/jbc.274.23.16242. ISSN 0021-9258. PMID 10347180. 
10. ^ Taniura, Hideo; Yoshikawa Kazuaki (2002). "Necdin interacts with the ribonucleoprotein hnRNP U in the nuclear matrix". J. Cell. Biochem. (United States) 84 (3): 545–55. doi:10.1002/jcb.10047. ISSN 0730-2312. PMID 11813259. 

Further reading

• Aizawa T, Maruyama K, Kondo H, Yoshikawa K (1992). "Expression of necdin, an embryonal carcinoma-derived nuclear protein, in developing mouse brain.". Brain Res. Dev. Brain Res. 68 (2): 265–74. doi:10.1016/0165-3806(92)90069-9. PMID 1394972. 
• Jay P, Rougeulle C, Massacrier A, et al. (1997). "The human necdin gene, NDN, is maternally imprinted and located in the Prader-Willi syndrome chromosomal region.". Nat. Genet. 17 (3): 357–61. doi:10.1038/ng1197-357. PMID 9354807. 
• Taniura H, Taniguchi N, Hara M, Yoshikawa K (1998). "Necdin, a postmitotic neuron-specific growth suppressor, interacts with viral transforming proteins and cellular transcription factor E2F1.". J. Biol. Chem. 273 (2): 720–8. doi:10.1074/jbc.273.2.720. PMID 9422723. 
• Nakada Y, Taniura H, Uetsuki T, et al. (1998). "The human chromosomal gene for necdin, a neuronal growth suppressor, in the Prader-Willi syndrome deletion region.". Gene 213 (1–2): 65–72. doi:10.1016/S0378-1119(98)00206-6. PMID 9630521. 
• Taniura H, Matsumoto K, Yoshikawa K (1999). "Physical and functional interactions of neuronal growth suppressor necdin with p53". J. Biol. Chem. 274 (23): 16242–8. doi:10.1074/jbc.274.23.16242. PMID 10347180. 
• Taniguchi N, Taniura H, Niinobe M, et al. (2000). "The postmitotic growth suppressor necdin interacts with a calcium-binding protein (NEFA) in neuronal cytoplasm". J. Biol. Chem. 275 (41): 31674–81. doi:10.1074/jbc.M005103200. PMID 10915798. 
• Niinobe M, Koyama K, Yoshikawa K (2000). "Cellular and subcellular localization of necdin in fetal and adult mouse brain". Dev. Neurosci. 22 (4): 310–9. doi:10.1159/000017455. PMID 10965153. 
• Taniura H, Yoshikawa K (2002). "Necdin interacts with the ribonucleoprotein hnRNP U in the nuclear matrix". J. Cell. Biochem. 84 (3): 545–55. doi:10.1002/jcb.10047. PMID 11813259. 
• Sasaki A, Masuda Y, Iwai K, et al. (2002). "A RING finger protein Praja1 regulates Dlx5-dependent transcription through its ubiquitin ligase activity for the Dlx/Msx-interacting MAGE/Necdin family protein, Dlxin-1". J. Biol. Chem. 277 (25): 22541–6. doi:10.1074/jbc.M109728200. PMID 11959851. 
• Kobayashi M, Taniura H, Yoshikawa K (2003). "Ectopic expression of necdin induces differentiation of mouse neuroblastoma cells". J. Biol. Chem. 277 (44): 42128–35. doi:10.1074/jbc.M205024200. PMID 12198120. 
• Tcherpakov M, Bronfman FC, Conticello SG, et al. (2003). "The p75 neurotrophin receptor interacts with multiple MAGE proteins". J. Biol. Chem. 277 (51): 49101–4. doi:10.1074/jbc.C200533200. PMID 12414813. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Bronfman FC, Tcherpakov M, Jovin TM, Fainzilber M (2003). "Ligand-induced internalization of the p75 neurotrophin receptor: a slow route to the signaling endosome". J. Neurosci. 23 (8): 3209–20. PMID 12716928. 
• Hu B, Wang S, Zhang Y, et al. (2003). "A nuclear target for interleukin-1alpha: interaction with the growth suppressor necdin modulates proliferation and collagen expression". Proc. Natl. Acad. Sci. U.S.A. 100 (17): 10008–13. doi:10.1073/pnas.1737765100. PMC 187743. PMID 12913118. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=187743. 
• Kuwako K, Taniura H, Yoshikawa K (2004). "Necdin-related MAGE proteins differentially interact with the E2F1 transcription factor and the p75 neurotrophin receptor". J. Biol. Chem. 279 (3): 1703–12. doi:10.1074/jbc.M308454200. PMID 14593116. 
• Lau JC, Hanel ML, Wevrick R (2004). "Tissue-specific and imprinted epigenetic modifications of the human NDN gene". Nucleic Acids Res. 32 (11): 3376–82. doi:10.1093/nar/gkh671. PMC 443546. PMID 15247330. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=443546. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Moon HE, Ahn MY, Park JA, et al. (2005). "Negative regulation of hypoxia inducible factor-1alpha by necdin". FEBS Lett. 579 (17): 3797–801. doi:10.1016/j.febslet.2005.05.072. PMID 15978586. 
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1847948.