POU4F1

POU4F1

POU domain, class 4, transcription factor 1, also known as POU4F1, is a human gene.cite web | title = Entrez Gene: POU4F1 POU domain, class 4, transcription factor 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5457| accessdate = ]

PBB_Summary
section_title =
summary_text = BRN3A (POU4F1) is a class IV POU domain-containing transcription factor highly expressed in the developing sensory nervous system and in cells of the B- and T-lymphocytic lineages (Gerrero et al., 1993). [supplied by OMIM] cite web | title = Entrez Gene: POU4F1 POU domain, class 4, transcription factor 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5457| accessdate = ]

ee also

* BRN-3

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Collum RG, Fisher PE, Datta M, "et al." |title=A novel POU homeodomain gene specifically expressed in cells of the developing mammalian nervous system. |journal=Nucleic Acids Res. |volume=20 |issue= 18 |pages= 4919–25 |year= 1992 |pmid= 1357630 |doi=
*cite journal | author=Xiang M, Zhou L, Macke JP, "et al." |title=The Brn-3 family of POU-domain factors: primary structure, binding specificity, and expression in subsets of retinal ganglion cells and somatosensory neurons. |journal=J. Neurosci. |volume=15 |issue= 7 Pt 1 |pages= 4762–85 |year= 1995 |pmid= 7623109 |doi=
*cite journal | author=Bhargava AK, Li Z, Weissman SM |title=Differential expression of four members of the POU family of proteins in activated and phorbol 12-myristate 13-acetate-treated Jurkat T cells. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=90 |issue= 21 |pages= 10260–4 |year= 1993 |pmid= 8234287 |doi=
*cite journal | author=Gerrero MR, McEvilly RJ, Turner E, "et al." |title=Brn-3.0: a POU-domain protein expressed in the sensory, immune, and endocrine systems that functions on elements distinct from known octamer motifs. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=90 |issue= 22 |pages= 10841–5 |year= 1993 |pmid= 8248179 |doi=
*cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=
*cite journal | author=Still IH, Cowell J |title=The Brn-3a transcription factor gene (POU4F1) maps close to the locus for the variant late infantile form of neuronal ceroid-lipofuscinosis. |journal=Cytogenet. Cell Genet. |volume=74 |issue= 3 |pages= 225–6 |year= 1996 |pmid= 8941380 |doi=
*cite journal | author=Smith MD, Dawson SJ, Latchman DS |title=Inhibition of neuronal process outgrowth and neuronal specific gene activation by the Brn-3b transcription factor. |journal=J. Biol. Chem. |volume=272 |issue= 2 |pages= 1382–8 |year= 1997 |pmid= 8995448 |doi=
*cite journal | author=Budhram-Mahadeo V, Parker M, Latchman DS |title=POU transcription factors Brn-3a and Brn-3b interact with the estrogen receptor and differentially regulate transcriptional activity via an estrogen response element. |journal=Mol. Cell. Biol. |volume=18 |issue= 2 |pages= 1029–41 |year= 1998 |pmid= 9448000 |doi=
*cite journal | author=Frass B, Vassen L, Möröy T |title=Gene expression of the POU factor Brn-3a is regulated by two different promoters. |journal=Biochim. Biophys. Acta |volume=1579 |issue= 2-3 |pages= 207–13 |year= 2003 |pmid= 12427558 |doi=
*cite journal | author=Thomas GR, Latchman DS |title=The pro-oncoprotein EWS (Ewing's Sarcoma protein) interacts with the Brn-3a POU transcription factor and inhibits its ability to activate transcription. |journal=Cancer Biol. Ther. |volume=1 |issue= 4 |pages= 428–32 |year= 2003 |pmid= 12432261 |doi=
*cite journal | author=Trieu M, Ma A, Eng SR, "et al." |title=Direct autoregulation and gene dosage compensation by POU-domain transcription factor Brn3a. |journal=Development |volume=130 |issue= 1 |pages= 111–21 |year= 2003 |pmid= 12441296 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Ma L, Lei L, Eng SR, "et al." |title=Brn3a regulation of TrkA/NGF receptor expression in developing sensory neurons. |journal=Development |volume=130 |issue= 15 |pages= 3525–34 |year= 2003 |pmid= 12810599 |doi=
*cite journal | author=Sindos M, Ndisang D, Pisal N, "et al." |title=Measurement of Brn-3a levels in Pap smears provides a novel diagnostic marker for the detection of cervical neoplasia. |journal=Gynecol. Oncol. |volume=90 |issue= 2 |pages= 366–71 |year= 2003 |pmid= 12893201 |doi=
*cite journal | author=Sindos M, Ndisang D, Pisal N, "et al." |title=Detection of cervical neoplasia using measurement of Brn-3a in cervical smears with persistent minor abnormality. |journal=Int. J. Gynecol. Cancer |volume=13 |issue= 4 |pages= 515–7 |year= 2004 |pmid= 12911730 |doi=
*cite journal | author=Calissano M, Latchman DS |title=Functional interaction between the small GTP-binding protein Rin and the N-terminal of Brn-3a transcription factor. |journal=Oncogene |volume=22 |issue= 35 |pages= 5408–14 |year= 2003 |pmid= 12934100 |doi= 10.1038/sj.onc.1206635
*cite journal | author=Gascoyne DM, Thomas GR, Latchman DS |title=The effects of Brn-3a on neuronal differentiation and apoptosis are differentially modulated by EWS and its oncogenic derivative EWS/Fli-1. |journal=Oncogene |volume=23 |issue= 21 |pages= 3830–40 |year= 2004 |pmid= 15021903 |doi= 10.1038/sj.onc.1207497
*cite journal | author=Farooqui-Kabir SR, Budhram-Mahadeo V, Lewis H, "et al." |title=Regulation of Hsp27 expression and cell survival by the POU transcription factor Brn3a. |journal=Cell Death Differ. |volume=11 |issue= 11 |pages= 1242–4 |year= 2005 |pmid= 15272315 |doi= 10.1038/sj.cdd.4401478
*cite journal | author=Ndisang D, Faulkes DJ, Gascoyne D, "et al." |title=Differential regulation of different human papilloma virus variants by the POU family transcription factor Brn-3a. |journal=Oncogene |volume=25 |issue= 1 |pages= 51–60 |year= 2006 |pmid= 16247485 |doi= 10.1038/sj.onc.1209006
*cite journal | author=Diss JK, Faulkes DJ, Walker MM, "et al." |title=Brn-3a neuronal transcription factor functional expression in human prostate cancer. |journal=Prostate Cancer Prostatic Dis. |volume=9 |issue= 1 |pages= 83–91 |year= 2006 |pmid= 16276351 |doi= 10.1038/sj.pcan.4500837

External links

*

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  • BRN-3 — protein Name = POU class 4 homeobox 1 caption = width = HGNCid = 9218 Symbol = POU4F1 AltSymbols = BRN3A EntrezGene = 5457 OMIM = 601632 RefSeq = NM 006237 UniProt = Q01851 PDB = ECnumber = Chromosome = 13 Arm = q Band = 31.1… …   Wikipedia

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  • POU-Familie — Die POU Familie ist eine Gruppe von Transkriptionsfaktoren mit einer hochkonservierten Homöodomäne. Im menschlichen Genom wurden 15 POU Gene gefunden. Das Genom der Modellorganismen Drosophila und Caenorhabditis elegans weist dagegen nur fünf… …   Deutsch Wikipedia

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