UBE2D3

Ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast), also known as UBE2D3, is a human gene.cite web | title = Entrez Gene: UBE2D3 ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7323| accessdate = ]

PBB_Summary
section_title =
summary_text = The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme functions in the ubiquitination of the tumor-suppressor protein p53, which is induced by an E3 ubiquitin-protein ligase. Multiple spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been determined.cite web | title = Entrez Gene: UBE2D3 ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7323| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Scheffner M, Huibregtse JM, Howley PM |title=Identification of a human ubiquitin-conjugating enzyme that mediates the E6-AP-dependent ubiquitination of p53. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=91 |issue= 19 |pages= 8797–801 |year= 1994 |pmid= 8090726 |doi=
*cite journal | author=Jensen JP, Bates PW, Yang M, "et al." |title=Identification of a family of closely related human ubiquitin conjugating enzymes. |journal=J. Biol. Chem. |volume=270 |issue= 51 |pages= 30408–14 |year= 1996 |pmid= 8530467 |doi=
*cite journal | author=Rogakou EP, Pilch DR, Orr AH, "et al." |title=DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139. |journal=J. Biol. Chem. |volume=273 |issue= 10 |pages= 5858–68 |year= 1998 |pmid= 9488723 |doi=
*cite journal | author=Anan T, Nagata Y, Koga H, "et al." |title=Human ubiquitin-protein ligase Nedd4: expression, subcellular localization and selective interaction with ubiquitin-conjugating enzymes. |journal=Genes Cells |volume=3 |issue= 11 |pages= 751–63 |year= 1999 |pmid= 9990509 |doi=
*cite journal | author=Gonen H, Bercovich B, Orian A, "et al." |title=Identification of the ubiquitin carrier proteins, E2s, involved in signal-induced conjugation and subsequent degradation of IkappaBalpha. |journal=J. Biol. Chem. |volume=274 |issue= 21 |pages= 14823–30 |year= 1999 |pmid= 10329681 |doi=
*cite journal | author=Orian A, Gonen H, Bercovich B, "et al." |title=SCF(beta)(-TrCP) ubiquitin ligase-mediated processing of NF-kappaB p105 requires phosphorylation of its C-terminus by IkappaB kinase. |journal=EMBO J. |volume=19 |issue= 11 |pages= 2580–91 |year= 2000 |pmid= 10835356 |doi= 10.1093/emboj/19.11.2580
*cite journal | author=Coleman CS, Pegg AE |title=Polyamine analogues inhibit the ubiquitination of spermidine/spermine N1-acetyltransferase and prevent its targeting to the proteasome for degradation. |journal=Biochem. J. |volume=358 |issue= Pt 1 |pages= 137–45 |year= 2001 |pmid= 11485561 |doi=
*cite journal | author=Chen A, Kleiman FE, Manley JL, "et al." |title=Autoubiquitination of the BRCA1*BARD1 RING ubiquitin ligase. |journal=J. Biol. Chem. |volume=277 |issue= 24 |pages= 22085–92 |year= 2002 |pmid= 11927591 |doi= 10.1074/jbc.M201252200
*cite journal | author=Obin M, Lee BY, Meinke G, "et al." |title=Ubiquitylation of the transducin betagamma subunit complex. Regulation by phosducin. |journal=J. Biol. Chem. |volume=277 |issue= 46 |pages= 44566–75 |year= 2003 |pmid= 12215439 |doi= 10.1074/jbc.M205308200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Takeyama K, Aguiar RC, Gu L, "et al." |title=The BAL-binding protein BBAP and related Deltex family members exhibit ubiquitin-protein isopeptide ligase activity. |journal=J. Biol. Chem. |volume=278 |issue= 24 |pages= 21930–7 |year= 2003 |pmid= 12670957 |doi= 10.1074/jbc.M301157200
*cite journal | author=Brzovic PS, Keeffe JR, Nishikawa H, "et al." |title=Binding and recognition in the assembly of an active BRCA1/BARD1 ubiquitin-ligase complex. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 10 |pages= 5646–51 |year= 2003 |pmid= 12732733 |doi= 10.1073/pnas.0836054100
*cite journal | author=Tang ED, Wang CY, Xiong Y, Guan KL |title=A role for NF-kappaB essential modifier/IkappaB kinase-gamma (NEMO/IKKgamma) ubiquitination in the activation of the IkappaB kinase complex by tumor necrosis factor-alpha. |journal=J. Biol. Chem. |volume=278 |issue= 39 |pages= 37297–305 |year= 2003 |pmid= 12867425 |doi= 10.1074/jbc.M303389200
*cite journal | author=Subramaniam V, Li H, Wong M, "et al." |title=The RING-H2 protein RNF11 is overexpressed in breast cancer and is a target of Smurf2 E3 ligase. |journal=Br. J. Cancer |volume=89 |issue= 8 |pages= 1538–44 |year= 2003 |pmid= 14562029 |doi= 10.1038/sj.bjc.6601301
*cite journal | author=Lehner B, Semple JI, Brown SE, "et al." |title=Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region. |journal=Genomics |volume=83 |issue= 1 |pages= 153–67 |year= 2004 |pmid= 14667819 |doi=
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Saville MK, Sparks A, Xirodimas DP, "et al." |title=Regulation of p53 by the ubiquitin-conjugating enzymes UbcH5B/C in vivo. |journal=J. Biol. Chem. |volume=279 |issue= 40 |pages= 42169–81 |year= 2004 |pmid= 15280377 |doi= 10.1074/jbc.M403362200
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Rual JF, Venkatesan K, Hao T, "et al." |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209
*cite journal | author=Kimura K, Wakamatsu A, Suzuki Y, "et al." |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406

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