DCP2

DCP2
DCP2 decapping enzyme homolog (S. cerevisiae)
Identifiers
Symbols DCP2; FLJ33245; NUDT20
External IDs OMIM609844 MGI1917890 HomoloGene13968 GeneCards: DCP2 Gene
Orthologs
Species Human Mouse
Entrez 167227 70640
Ensembl ENSG00000172795 ENSMUSG00000024472
UniProt Q8IU60 Q3TLD9
RefSeq (mRNA) NM_001242377.1 NM_027490.1
RefSeq (protein) NP_001229306.1 NP_081766.1
Location (UCSC) Chr 5:
112.31 – 112.36 Mb
Chr 18:
44.54 – 44.58 Mb
PubMed search [1] [2]

mRNA-decapping enzyme 2 is a protein that in humans is encoded by the DCP2 gene.[1][2][3]

DCP2 is a key component of an mRNA-decapping complex required for removal of the 5-prime cap from mRNA prior to its degradation from the 5-prime end (Fenger-Gron et al., 2005).[supplied by OMIM][3]

Interactions

DCP2 has been shown to interact with DCP1A[2] and UPF1.[4][2]

References

  1. ^ Wang Z, Jiao X, Carr-Schmid A, Kiledjian M (Oct 2002). "The hDcp2 protein is a mammalian mRNA decapping enzyme pro-caratine". Proc Natl Acad Sci U S A 99 (20): 12663–8. doi:10.1073/pnas.192445599. PMC 130517. PMID 12218187. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=130517. 
  2. ^ a b c Lykke-Andersen J (Nov 2002). "Identification of a human decapping complex associated with hUpf proteins in nonsense-mediated decay". Mol Cell Biol 22 (23): 8114–21. doi:10.1128/MCB.22.23.8114-8121.2002. PMC 134073. PMID 12417715. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=134073. 
  3. ^ a b "Entrez Gene: DCP2 DCP2 decapping enzyme homolog (S. cerevisiae)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=167227. 
  4. ^ Lejeune, Fabrice; Li Xiaojie, Maquat Lynne E (Sep. 2003). "Nonsense-mediated mRNA decay in mammalian cells involves decapping, deadenylating, and exonucleolytic activities". Mol. Cell (United States) 12 (3): 675–87. doi:10.1016/S1097-2765(03)00349-6. ISSN 1097-2765. PMID 14527413. 

Further reading



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