HOXD9

Homeobox D9, also known as HOXD9, is a human gene.cite web | title = Entrez Gene: HOXD9 homeobox D9| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3235| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located at 2q31-2q37 chromosome regions. Deletions that removed the entire HOXD gene cluster or 5' end of this cluster have been associated with severe limb and genital abnormalities. The exact role of this gene has not been determined.cite web | title = Entrez Gene: HOXD9 homeobox D9| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3235| accessdate = ]

ee also

* Homeobox

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Scott MP |title=Vertebrate homeobox gene nomenclature. |journal=Cell |volume=71 |issue= 4 |pages= 551–3 |year= 1992 |pmid= 1358459 |doi=
*cite journal | author=Zappavigna V, Renucci A, Izpisúa-Belmonte JC, "et al." |title=HOX4 genes encode transcription factors with potential auto- and cross-regulatory capacities. |journal=EMBO J. |volume=10 |issue= 13 |pages= 4177–87 |year= 1992 |pmid= 1756725 |doi=
*cite journal | author=McAlpine PJ, Shows TB |title=Nomenclature for human homeobox genes. |journal=Genomics |volume=7 |issue= 3 |pages= 460 |year= 1990 |pmid= 1973146 |doi=
*cite journal | author=Oliver G, Sidell N, Fiske W, "et al." |title=Complementary homeo protein gradients in developing limb buds. |journal=Genes Dev. |volume=3 |issue= 5 |pages= 641–50 |year= 1989 |pmid= 2568311 |doi=
*cite journal | author=Acampora D, D'Esposito M, Faiella A, "et al." |title=The human HOX gene family. |journal=Nucleic Acids Res. |volume=17 |issue= 24 |pages= 10385–402 |year= 1990 |pmid= 2574852 |doi=
*cite journal | author=Kanzler B, Viallet JP, Le Mouellic H, "et al." |title=Differential expression of two different homeobox gene families during mouse tegument morphogenesis. |journal=Int. J. Dev. Biol. |volume=38 |issue= 4 |pages= 633–40 |year= 1995 |pmid= 7779685 |doi=
*cite journal | author=Zappavigna V, Sartori D, Mavilio F |title=Specificity of HOX protein function depends on DNA-protein and protein-protein interactions, both mediated by the homeo domain. |journal=Genes Dev. |volume=8 |issue= 6 |pages= 732–44 |year= 1994 |pmid= 7926763 |doi=
*cite journal | author=Zappavigna V, Falciola L, Helmer-Citterich M, "et al." |title=HMG1 interacts with HOX proteins and enhances their DNA binding and transcriptional activation. |journal=EMBO J. |volume=15 |issue= 18 |pages= 4981–91 |year= 1996 |pmid= 8890171 |doi=
*cite journal | author=Phelan ML, Featherstone MS |title=Distinct HOX N-terminal arm residues are responsible for specificity of DNA recognition by HOX monomers and HOX.PBX heterodimers. |journal=J. Biol. Chem. |volume=272 |issue= 13 |pages= 8635–43 |year= 1997 |pmid= 9079695 |doi=
*cite journal | author=Del Campo M, Jones MC, Veraksa AN, "et al." |title=Monodactylous limbs and abnormal genitalia are associated with hemizygosity for the human 2q31 region that includes the HOXD cluster. |journal=Am. J. Hum. Genet. |volume=65 |issue= 1 |pages= 104–10 |year= 1999 |pmid= 10364522 |doi=
*cite journal | author=de la Cruz CC, Der-Avakian A, Spyropoulos DD, "et al." |title=Targeted disruption of Hoxd9 and Hoxd10 alters locomotor behavior, vertebral identity, and peripheral nervous system development. |journal=Dev. Biol. |volume=216 |issue= 2 |pages= 595–610 |year= 2000 |pmid= 10642795 |doi= 10.1006/dbio.1999.9528
*cite journal | author=Limongi MZ, Pelliccia F, Gaddini L, Rocchi A |title=Clustering of two fragile sites and seven homeobox genes in human chromosome region 2q31-->q32.1. |journal=Cytogenet. Cell Genet. |volume=90 |issue= 1-2 |pages= 151–3 |year= 2000 |pmid= 11060466 |doi=
*cite journal | author=Goodman FR, Majewski F, Collins AL, Scambler PJ |title=A 117-kb microdeletion removing HOXD9-HOXD13 and EVX2 causes synpolydactyly. |journal=Am. J. Hum. Genet. |volume=70 |issue= 2 |pages= 547–55 |year= 2002 |pmid= 11778160 |doi=
*cite journal | author=Kosaki K, Kosaki R, Suzuki T, "et al." |title=Complete mutation analysis panel of the 39 human HOX genes. |journal=Teratology |volume=65 |issue= 2 |pages= 50–62 |year= 2002 |pmid= 11857506 |doi= 10.1002/tera.10009
*cite journal | author=Nguyen NC, Hirose T, Nakazawa M, "et al." |title=Expression of HOXD9 in fibroblast-like synoviocytes from rheumatoid arthritis patients. |journal=Int. J. Mol. Med. |volume=10 |issue= 1 |pages= 41–8 |year= 2002 |pmid= 12060849 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Méchine-Neuville A, Lefebvre O, Bellocq JP, "et al." |title= [Increased expression of HOXA9 gene in Hirschsprung disease] |journal=Gastroenterol. Clin. Biol. |volume=26 |issue= 12 |pages= 1110–7 |year= 2003 |pmid= 12520199 |doi=
*cite journal | author=Liu DB, Gu ZD, Cao XZ, "et al." |title=Immunocytochemical detection of HoxD9 and Pbx1 homeodomain protein expression in Chinese esophageal squamous cell carcinomas. |journal=World J. Gastroenterol. |volume=11 |issue= 10 |pages= 1562–6 |year= 2005 |pmid= 15770739 |doi=
*cite journal | author=Zhao X, Sun M, Zhao J, "et al." |title=Mutations in HOXD13 underlie syndactyly type V and a novel brachydactyly-syndactyly syndrome. |journal=Am. J. Hum. Genet. |volume=80 |issue= 2 |pages= 361–71 |year= 2007 |pmid= 17236141 |doi= 10.1086/511387

External links

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