HR (gene)

HR (gene)

Hairless homolog (mouse), also known as HR, is a human gene.cite web | title = Entrez Gene: HR hairless homolog (mouse)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55806| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes a protein whose function has been linked to hair growth. A similar protein in rat functions as a transcriptional corepressor for thyroid hormone and interacts with histone deacetylases. Mutations in this gene have been documented in cases of autosomal recessive congenital alopecia and atrichia with papular lesions.cite web | title = Entrez Gene: HR hairless homolog (mouse)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55806| accessdate = ]

ee also

*Corepressor

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Ahmad M, Abbas H, Haque S |title=Alopecia universalis as a single abnormality in an inbred Pakistani kindred. |journal=Am. J. Med. Genet. |volume=46 |issue= 4 |pages= 369–71 |year= 1993 |pmid= 8357006 |doi= 10.1002/ajmg.1320460405
*cite journal | author=Ahmad W, Faiyaz ul Haque M, Brancolini V, "et al." |title=Alopecia universalis associated with a mutation in the human hairless gene. |journal=Science |volume=279 |issue= 5351 |pages= 720–4 |year= 1998 |pmid= 9445480 |doi=
*cite journal | author=Nöthen MM, Cichon S, Vogt IR, "et al." |title=A gene for universal congenital alopecia maps to chromosome 8p21-22. |journal=Am. J. Hum. Genet. |volume=62 |issue= 2 |pages= 386–90 |year= 1998 |pmid= 9463324 |doi=
*cite journal | author=Cichon S, Anker M, Vogt IR, "et al." |title=Cloning, genomic organization, alternative transcripts and mutational analysis of the gene responsible for autosomal recessive universal congenital alopecia. |journal=Hum. Mol. Genet. |volume=7 |issue= 11 |pages= 1671–9 |year= 1998 |pmid= 9736769 |doi=
*cite journal | author=Ahmad W, Irvine AD, Lam H, "et al." |title=A missense mutation in the zinc-finger domain of the human hairless gene underlies congenital atrichia in a family of Irish travellers. |journal=Am. J. Hum. Genet. |volume=63 |issue= 4 |pages= 984–91 |year= 1998 |pmid= 9758627 |doi=
*cite journal | author=Ahmad W, Zlotogorski A, Panteleyev AA, "et al." |title=Genomic organization of the human hairless gene (HR) and identification of a mutation underlying congenital atrichia in an Arab Palestinian family. |journal=Genomics |volume=56 |issue= 2 |pages= 141–8 |year= 1999 |pmid= 10051399 |doi= 10.1006/geno.1998.5699
*cite journal | author=Sprecher E, Bergman R, Szargel R, "et al." |title=Identification of a genetic defect in the hairless gene in atrichia with papular lesions: evidence for phenotypic heterogeneity among inherited atrichias. |journal=Am. J. Hum. Genet. |volume=64 |issue= 5 |pages= 1323–9 |year= 1999 |pmid= 10205263 |doi=
*cite journal | author=Ahmad W, Nomura K, McGrath JA, "et al." |title=A homozygous nonsense mutation in the zinc-finger domain of the human hairless gene underlies congenital atrichia. |journal=J. Invest. Dermatol. |volume=113 |issue= 2 |pages= 281–3 |year= 1999 |pmid= 10469319 |doi= 10.1046/j.1523-1747.1999.00686.x
*cite journal | author=Hillmer AM, Kruse R, Betz RC, "et al." |title=Variant 1859G-->A (Arg620Gln) of the "hairless" gene: absence of association with papular atrichia or androgenic alopecia. |journal=Am. J. Hum. Genet. |volume=69 |issue= 1 |pages= 235–7 |year= 2001 |pmid= 11410842 |doi=
*cite journal | author=Potter GB, Beaudoin GM, DeRenzo CL, "et al." |title=The hairless gene mutated in congenital hair loss disorders encodes a novel nuclear receptor corepressor. |journal=Genes Dev. |volume=15 |issue= 20 |pages= 2687–701 |year= 2001 |pmid= 11641275 |doi= 10.1101/gad.916701
*cite journal | author=Dintilhac A, Bernués J |title=HMGB1 interacts with many apparently unrelated proteins by recognizing short amino acid sequences. |journal=J. Biol. Chem. |volume=277 |issue= 9 |pages= 7021–8 |year= 2002 |pmid= 11748221 |doi= 10.1074/jbc.M108417200
*cite journal | author=Hillmer AM, Kruse R, Macciardi F, "et al." |title=The hairless gene in androgenetic alopecia: results of a systematic mutation screening and a family-based association approach. |journal=Br. J. Dermatol. |volume=146 |issue= 4 |pages= 601–8 |year= 2002 |pmid= 11966690 |doi=
*cite journal | author=Henn W, Zlotogorski A, Lam H, "et al." |title=Atrichia with papular lesions resulting from compound heterozygous mutations in the hairless gene: A lesson for differential diagnosis of alopecia universalis. |journal=J. Am. Acad. Dermatol. |volume=47 |issue= 4 |pages= 519–23 |year= 2002 |pmid= 12271294 |doi=
*cite journal | author=Klein I, Bergman R, Indelman M, Sprecher E |title=A novel missense mutation affecting the human hairless thyroid receptor interacting domain 2 causes congenital atrichia. |journal=J. Invest. Dermatol. |volume=119 |issue= 4 |pages= 920–2 |year= 2002 |pmid= 12406339 |doi= 10.1046/j.1523-1747.2002.00268.x
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Fernández A, Silió L, Noguera JL, "et al." |title=Linkage mapping of the porcine hairless gene (HR ) to chromosome 14. |journal=Anim. Genet. |volume=34 |issue= 4 |pages= 317–8 |year= 2004 |pmid= 12873232 |doi=
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Xie Z, Chang S, Oda Y, Bikle DD |title=Hairless suppresses vitamin D receptor transactivation in human keratinocytes. |journal=Endocrinology |volume=147 |issue= 1 |pages= 314–23 |year= 2006 |pmid= 16269453 |doi= 10.1210/en.2005-1111
*cite journal | author=Betz RC, Indelman M, Pforr J, "et al." |title=Identification of mutations in the human hairless gene in two new families with congenital atrichia. |journal=Arch. Dermatol. Res. |volume=299 |issue= 3 |pages= 157–61 |year= 2007 |pmid= 17372750 |doi= 10.1007/s00403-007-0747-8

External links

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