MAP3K12

MAP3K12

Mitogen-activated protein kinase kinase kinase 12, also known as MAP3K12, is a human gene.cite web | title = Entrez Gene: MAP3K12 mitogen-activated protein kinase kinase kinase 12| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7786| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene is a member of serine/threonine protein kinase family. This kinase contains a leucine-zipper domain, and is predominately expressed in neuronal cells. The phosphorylation state of this kinase in synaptic terminals was shown to be regulated by membrane depolarization via calcineurin. This kinase forms heterodimers with leucine zipper containing transcription factors, such as cAMP responsive element binding protein (CREB) and MYC, and thus may play a regulatory role in PKA or retinoic acid induced neuronal differentiation.cite web | title = Entrez Gene: MAP3K12 mitogen-activated protein kinase kinase kinase 12| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7786| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Reddy UR, Nycum L, Slavc I, Biegel JA |title=Localization of the human zipper protein kinase gene (ZPK) to chromosome 12q13 by fluorescence in situ hybridization and somatic cell hybrid analysis. |journal=Genomics |volume=25 |issue= 2 |pages= 597–8 |year= 1995 |pmid= 7790002 |doi=
*cite journal | author=Holzman LB, Merritt SE, Fan G |title=Identification, molecular cloning, and characterization of dual leucine zipper bearing kinase. A novel serine/threonine protein kinase that defines a second subfamily of mixed lineage kinases. |journal=J. Biol. Chem. |volume=269 |issue= 49 |pages= 30808–17 |year= 1995 |pmid= 7983011 |doi=
*cite journal | author=Reddy UR, Pleasure D |title=Cloning of a novel putative protein kinase having a leucine zipper domain from human brain. |journal=Biochem. Biophys. Res. Commun. |volume=202 |issue= 1 |pages= 613–20 |year= 1994 |pmid= 8037767 |doi= 10.1006/bbrc.1994.1972
*cite journal | author=Hirai S, Izawa M, Osada S, "et al." |title=Activation of the JNK pathway by distantly related protein kinases, MEKK and MUK. |journal=Oncogene |volume=12 |issue= 3 |pages= 641–50 |year= 1996 |pmid= 8637721 |doi=
*cite journal | author=Mata M, Merritt SE, Fan G, "et al." |title=Characterization of dual leucine zipper-bearing kinase, a mixed lineage kinase present in synaptic terminals whose phosphorylation state is regulated by membrane depolarization via calcineurin. |journal=J. Biol. Chem. |volume=271 |issue= 28 |pages= 16888–96 |year= 1996 |pmid= 8663324 |doi=
*cite journal | author=Sakuma H, Ikeda A, Oka S, "et al." |title=Molecular cloning and functional expression of a cDNA encoding a new member of mixed lineage protein kinase from human brain. |journal=J. Biol. Chem. |volume=272 |issue= 45 |pages= 28622–9 |year= 1997 |pmid= 9353328 |doi=
*cite journal | author=Merritt SE, Mata M, Nihalani D, "et al." |title=The mixed lineage kinase DLK utilizes MKK7 and not MKK4 as substrate. |journal=J. Biol. Chem. |volume=274 |issue= 15 |pages= 10195–202 |year= 1999 |pmid= 10187804 |doi=
*cite journal | author=Reddy UR, Basu A, Bannerman P, "et al." |title=ZPK inhibits PKA induced transcriptional activation by CREB and blocks retinoic acid induced neuronal differentiation. |journal=Oncogene |volume=18 |issue= 31 |pages= 4474–84 |year= 1999 |pmid= 10442638 |doi= 10.1038/sj.onc.1202813
*cite journal | author=Douziech M, Laberge G, Grondin G, "et al." |title=Localization of the mixed-lineage kinase DLK/MUK/ZPK to the Golgi apparatus in NIH 3T3 cells. |journal=J. Histochem. Cytochem. |volume=47 |issue= 10 |pages= 1287–96 |year= 1999 |pmid= 10490457 |doi=
*cite journal | author=Fukuyama K, Yoshida M, Yamashita A, "et al." |title=MAPK upstream kinase (MUK)-binding inhibitory protein, a negative regulator of MUK/dual leucine zipper-bearing kinase/leucine zipper protein kinase. |journal=J. Biol. Chem. |volume=275 |issue= 28 |pages= 21247–54 |year= 2000 |pmid= 10801814 |doi= 10.1074/jbc.M001488200
*cite journal | author=Hébert SS, Daviau A, Grondin G, "et al." |title=The mixed lineage kinase DLK is oligomerized by tissue transglutaminase during apoptosis. |journal=J. Biol. Chem. |volume=275 |issue= 42 |pages= 32482–90 |year= 2000 |pmid= 10922377 |doi= 10.1074/jbc.M006528200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Figueroa C, Tarras S, Taylor J, Vojtek AB |title=Akt2 negatively regulates assembly of the POSH-MLK-JNK signaling complex. |journal=J. Biol. Chem. |volume=278 |issue= 48 |pages= 47922–7 |year= 2004 |pmid= 14504284 |doi= 10.1074/jbc.M307357200
*cite journal | author=Itoh A, Wang Z, Ito Y, "et al." |title=SP3 acts as a positive regulator on the core promoter of human ZPK gene. |journal=Biochem. Biophys. Res. Commun. |volume=313 |issue= 3 |pages= 612–8 |year= 2004 |pmid= 14697235 |doi=
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Graves PR, Winkfield KM, Haystead TA |title=Regulation of zipper-interacting protein kinase activity in vitro and in vivo by multisite phosphorylation. |journal=J. Biol. Chem. |volume=280 |issue= 10 |pages= 9363–74 |year= 2005 |pmid= 15611134 |doi= 10.1074/jbc.M412538200
*cite journal | author=Robitaille H, Proulx R, Robitaille K, "et al." |title=The mitogen-activated protein kinase kinase kinase dual leucine zipper-bearing kinase (DLK) acts as a key regulator of keratinocyte terminal differentiation. |journal=J. Biol. Chem. |volume=280 |issue= 13 |pages= 12732–41 |year= 2005 |pmid= 15695824 |doi= 10.1074/jbc.M411619200
*cite journal | author=Stelzl U, Worm U, Lalowski M, "et al." |title=A human protein-protein interaction network: a resource for annotating the proteome. |journal=Cell |volume=122 |issue= 6 |pages= 957–68 |year= 2005 |pmid= 16169070 |doi= 10.1016/j.cell.2005.08.029

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