HOPX

Homeodomain-only protein, also known as HOP, is a human gene.cite web | title = Entrez Gene: HOP homeodomain-only protein| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=84525| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene is a homeodomain protein that lacks certain conserved residues required for DNA binding. It was reported that choriocarcinoma cell lines and tissues failed to express this gene, which suggested the possible involvement of this gene in malignant conversion of placental trophoblasts. Studies in mice suggested that this protein may interact with serum response factor (SRF) and modulate SRF-dependent cardiac-specific gene expression and cardiac development. Multiple alternatively spliced transcript variants encoding the same protein have been observed, the full-length natures of only some have been determined.cite web | title = Entrez Gene: HOP homeodomain-only protein| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=84525| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Kook H, Epstein JA |title=Hopping to the beat. Hop regulation of cardiac gene expression. |journal=Trends Cardiovasc. Med. |volume=13 |issue= 7 |pages= 261–4 |year= 2004 |pmid= 14522464 |doi=
*cite journal | author=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination. |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788–95 |year= 2001 |pmid= 11076863 |doi=
*cite journal | author=Chen F, Kook H, Milewski R, "et al." |title=Hop is an unusual homeobox gene that modulates cardiac development. |journal=Cell |volume=110 |issue= 6 |pages= 713–23 |year= 2002 |pmid= 12297045 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Asanoma K, Matsuda T, Kondo H, "et al." |title=NECC1, a candidate choriocarcinoma suppressor gene that encodes a homeodomain consensus motif. |journal=Genomics |volume=81 |issue= 1 |pages= 15–25 |year= 2003 |pmid= 12573257 |doi=
*cite journal | author=Chen Y, Petersen S, Pacyna-Gengelbach M, "et al." |title=Identification of a novel homeobox-containing gene, LAGY, which is downregulated in lung cancer. |journal=Oncology |volume=64 |issue= 4 |pages= 450–8 |year= 2003 |pmid= 12759545 |doi= 10.1159/000070306
*cite journal | author=Kook H, Lepore JJ, Gitler AD, "et al." |title=Cardiac hypertrophy and histone deacetylase-dependent transcriptional repression mediated by the atypical homeodomain protein Hop. |journal=J. Clin. Invest. |volume=112 |issue= 6 |pages= 863–71 |year= 2003 |pmid= 12975471 |doi= 10.1172/JCI200319137
*cite journal | author=Adu J, Leong FT, Smith NR, "et al." |title=Expression of mOb1, a novel atypical 73 amino acid K50-homeodomain protein, during mouse development. |journal=Mech. Dev. |volume=119 Suppl 1 |issue= |pages= S43–7 |year= |pmid= 14516659 |doi=
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Lemaire F, Millon R, Muller D, "et al." |title=Loss of HOP tumour suppressor expression in head and neck squamous cell carcinoma. |journal=Br. J. Cancer |volume=91 |issue= 2 |pages= 258–61 |year= 2004 |pmid= 15213722 |doi= 10.1038/sj.bjc.6601952
*cite journal | author=Pauws E, Sijmons GG, Yaka C, Ris-Stalpers C |title=A novel homeobox gene overexpressed in thyroid carcinoma. |journal=Thyroid |volume=14 |issue= 7 |pages= 500–5 |year= 2005 |pmid= 15307938 |doi= 10.1089/1050725041517020
*cite journal | author=Toruner GA, Ulger C, Alkan M, "et al." |title=Association between gene expression profile and tumor invasion in oral squamous cell carcinoma. |journal=Cancer Genet. Cytogenet. |volume=154 |issue= 1 |pages= 27–35 |year= 2004 |pmid= 15381369 |doi= 10.1016/j.cancergencyto.2004.01.026
*cite journal | author=Asanoma K, Kato H, Inoue T, "et al." |title=Analysis of a candidate gene associated with growth suppression of choriocarcinoma and differentiation of trophoblasts. |journal=The Journal of reproductive medicine |volume=49 |issue= 8 |pages= 617–26 |year= 2004 |pmid= 15457851 |doi=
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Wiemann S, Arlt D, Huber W, "et al." |title=From ORFeome to biology: a functional genomics pipeline. |journal=Genome Res. |volume=14 |issue= 10B |pages= 2136–44 |year= 2004 |pmid= 15489336 |doi= 10.1101/gr.2576704
*cite journal | author=Mehrle A, Rosenfelder H, Schupp I, "et al." |title=The LIFEdb database in 2006. |journal=Nucleic Acids Res. |volume=34 |issue= Database issue |pages= D415–8 |year= 2006 |pmid= 16381901 |doi= 10.1093/nar/gkj139
*cite journal | author=Kook H, Yung WW, Simpson RJ, "et al." |title=Analysis of the structure and function of the transcriptional coregulator HOP. |journal=Biochemistry |volume=45 |issue= 35 |pages= 10584–90 |year= 2006 |pmid= 16939210 |doi= 10.1021/bi060641s
*cite journal | author=Kee HJ, Kim JR, Nam KI, "et al." |title=Enhancer of polycomb1, a novel homeodomain only protein-binding partner, induces skeletal muscle differentiation. |journal=J. Biol. Chem. |volume=282 |issue= 10 |pages= 7700–9 |year= 2007 |pmid= 17192267 |doi= 10.1074/jbc.M611198200
*cite journal | author=Americo TA, Chiarini LB, Linden R |title=Signaling induced by hop/STI-1 depends on endocytosis. |journal=Biochem. Biophys. Res. Commun. |volume=358 |issue= 2 |pages= 620–5 |year= 2007 |pmid= 17498662 |doi= 10.1016/j.bbrc.2007.04.202

External links

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