LATS1

LATS1

LATS, large tumor suppressor, homolog 1 (Drosophila), also known as LATS1, is a human gene.cite web | title = Entrez Gene: LATS1 LATS, large tumor suppressor, homolog 1 (Drosophila)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9113| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. Biochemical and genetic data suggest a role as a tumor suppressor. This is supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments.cite web | title = Entrez Gene: LATS1 LATS, large tumor suppressor, homolog 1 (Drosophila)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9113| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Xu T, Wang W, Zhang S, "et al." |title=Identifying tumor suppressors in genetic mosaics: the Drosophila lats gene encodes a putative protein kinase. |journal=Development |volume=121 |issue= 4 |pages= 1053–63 |year= 1995 |pmid= 7743921 |doi=
*cite journal | author=Tao W, Zhang S, Turenchalk GS, "et al." |title=Human homologue of the Drosophila melanogaster lats tumour suppressor modulates CDC2 activity. |journal=Nat. Genet. |volume=21 |issue= 2 |pages= 177–81 |year= 1999 |pmid= 9988268 |doi= 10.1038/5960
*cite journal | author=St John MA, Tao W, Fei X, "et al." |title=Mice deficient of Lats1 develop soft-tissue sarcomas, ovarian tumours and pituitary dysfunction. |journal=Nat. Genet. |volume=21 |issue= 2 |pages= 182–6 |year= 1999 |pmid= 9988269 |doi= 10.1038/5965
*cite journal | author=Nishiyama Y, Hirota T, Morisaki T, "et al." |title=A human homolog of Drosophila warts tumor suppressor, h-warts, localized to mitotic apparatus and specifically phosphorylated during mitosis. |journal=FEBS Lett. |volume=459 |issue= 2 |pages= 159–65 |year= 1999 |pmid= 10518011 |doi=
*cite journal | author=Hirota T, Morisaki T, Nishiyama Y, "et al." |title=Zyxin, a regulator of actin filament assembly, targets the mitotic apparatus by interacting with h-warts/LATS1 tumor suppressor. |journal=J. Cell Biol. |volume=149 |issue= 5 |pages= 1073–86 |year= 2000 |pmid= 10831611 |doi=
*cite journal | author=Morisaki T, Hirota T, Iida S, "et al." |title=WARTS tumor suppressor is phosphorylated by Cdc2/cyclin B at spindle poles during mitosis. |journal=FEBS Lett. |volume=529 |issue= 2-3 |pages= 319–24 |year= 2002 |pmid= 12372621 |doi=
*cite journal | author=Hisaoka M, Tanaka A, Hashimoto H |title=Molecular alterations of h-warts/LATS1 tumor suppressor in human soft tissue sarcoma. |journal=Lab. Invest. |volume=82 |issue= 10 |pages= 1427–35 |year= 2002 |pmid= 12379777 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Kamikubo Y, Takaori-Kondo A, Uchiyama T, Hori T |title=Inhibition of cell growth by conditional expression of kpm, a human homologue of Drosophila warts/lats tumor suppressor. |journal=J. Biol. Chem. |volume=278 |issue= 20 |pages= 17609–14 |year= 2003 |pmid= 12624101 |doi= 10.1074/jbc.M211974200
*cite journal | author=Iida S, Hirota T, Morisaki T, "et al." |title=Tumor suppressor WARTS ensures genomic integrity by regulating both mitotic progression and G1 tetraploidy checkpoint function. |journal=Oncogene |volume=23 |issue= 31 |pages= 5266–74 |year= 2004 |pmid= 15122335 |doi= 10.1038/sj.onc.1207623
*cite journal | author=Brill LM, Salomon AR, Ficarro SB, "et al." |title=Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. |journal=Anal. Chem. |volume=76 |issue= 10 |pages= 2763–72 |year= 2004 |pmid= 15144186 |doi= 10.1021/ac035352d
*cite journal | author=Yang X, Yu K, Hao Y, "et al." |title=LATS1 tumour suppressor affects cytokinesis by inhibiting LIMK1. |journal=Nat. Cell Biol. |volume=6 |issue= 7 |pages= 609–17 |year= 2004 |pmid= 15220930 |doi= 10.1038/ncb1140
*cite journal | author=Beausoleil SA, Jedrychowski M, Schwartz D, "et al." |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130–5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Chan EH, Nousiainen M, Chalamalasetty RB, "et al." |title=The Ste20-like kinase Mst2 activates the human large tumor suppressor kinase Lats1. |journal=Oncogene |volume=24 |issue= 12 |pages= 2076–86 |year= 2005 |pmid= 15688006 |doi= 10.1038/sj.onc.1208445
*cite journal | author=Takahashi Y, Miyoshi Y, Takahata C, "et al." |title=Down-regulation of LATS1 and LATS2 mRNA expression by promoter hypermethylation and its association with biologically aggressive phenotype in human breast cancers. |journal=Clin. Cancer Res. |volume=11 |issue= 4 |pages= 1380–5 |year= 2005 |pmid= 15746036 |doi= 10.1158/1078-0432.CCR-04-1773
*cite journal | author=Kuninaka S, Nomura M, Hirota T, "et al." |title=The tumor suppressor WARTS activates the Omi / HtrA2-dependent pathway of cell death. |journal=Oncogene |volume=24 |issue= 34 |pages= 5287–98 |year= 2005 |pmid= 16007220 |doi= 10.1038/sj.onc.1208682
*cite journal | author=Bothos J, Tuttle RL, Ottey M, "et al." |title=Human LATS1 is a mitotic exit network kinase. |journal=Cancer Res. |volume=65 |issue= 15 |pages= 6568–75 |year= 2005 |pmid= 16061636 |doi= 10.1158/0008-5472.CAN-05-0862
*cite journal | author=Jiang Z, Li X, Hu J, "et al." |title=Promoter hypermethylation-mediated down-regulation of LATS1 and LATS2 in human astrocytoma. |journal=Neurosci. Res. |volume=56 |issue= 4 |pages= 450–8 |year= 2007 |pmid= 17049657 |doi= 10.1016/j.neures.2006.09.006

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