ADH4

Alcohol dehydrogenase 4 (class II), pi polypeptide, also known as ADH4, is a human gene.cite web | title = Entrez Gene: ADH4 alcohol dehydrogenase 4 (class II), pi polypeptide| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=127| accessdate = ]

PBB_Summary
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summary_text = This gene encodes class II alcohol dehydrogenase 4 pi subunit, which is a member of the alcohol dehydrogenase family. Members of this enzyme family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. Class II alcohol dehydrogenase is a homodimer composed of 2 pi subunits. It exhibits a high activity for oxidation of long-chain aliphatic alcohols and aromatic alcohols and is less sensitive to pyrazole. This gene is localized to chromosome 4 in the cluster of alcohol dehydrogenase genes.cite web | title = Entrez Gene: ADH4 alcohol dehydrogenase 4 (class II), pi polypeptide| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=127| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Jörnvall H |title=The alcohol dehydrogenase system. |journal=EXS |volume=71 |issue= |pages= 221–9 |year= 1994 |pmid= 8032153 |doi=
*cite journal | author=Edman K, Maret W |title=Alcohol dehydrogenase genes: restriction fragment length polymorphisms for ADH4 (pi-ADH) and ADH5 (chi-ADH) and construction of haplotypes among different ADH classes. |journal=Hum. Genet. |volume=90 |issue= 4 |pages= 395–401 |year= 1993 |pmid= 1362387 |doi=
*cite journal | author=von Bahr-Lindström H, Jörnvall H, Höög JO |title=Cloning and characterization of the human ADH4 gene. |journal=Gene |volume=103 |issue= 2 |pages= 269–74 |year= 1991 |pmid= 1889753 |doi=
*cite journal | author=Höög JO, von Bahr-Lindström H, Hedén LO, "et al." |title=Structure of the class II enzyme of human liver alcohol dehydrogenase: combined cDNA and protein sequence determination of the pi subunit. |journal=Biochemistry |volume=26 |issue= 7 |pages= 1926–32 |year= 1987 |pmid= 3036213 |doi=
*cite journal | author=Mårdh G, Dingley AL, Auld DS, Vallee BL |title=Human class II (pi) alcohol dehydrogenase has a redox-specific function in norepinephrine metabolism. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=83 |issue= 23 |pages= 8908–12 |year= 1987 |pmid= 3466164 |doi=
*cite journal | author=Li M, Edenberg HJ |title=Function of cis-acting elements in human alcohol dehydrogenase 4 (ADH4) promoter and role of C/EBP proteins in gene expression. |journal=DNA Cell Biol. |volume=17 |issue= 4 |pages= 387–97 |year= 1998 |pmid= 9570155 |doi=
*cite journal | author=Tryggvason K, Romert A, Eriksson U |title=Biosynthesis of 9-cis-retinoic acid in vivo. The roles of different retinol dehydrogenases and a structure-activity analysis of microsomal retinol dehydrogenases. |journal=J. Biol. Chem. |volume=276 |issue= 22 |pages= 19253–8 |year= 2001 |pmid= 11279029 |doi= 10.1074/jbc.M100215200
*cite journal | author=Xu XR, Huang J, Xu ZG, "et al." |title=Insight into hepatocellular carcinogenesis at transcriptome level by comparing gene expression profiles of hepatocellular carcinoma with those of corresponding noncancerous liver. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 26 |pages= 15089–94 |year= 2002 |pmid= 11752456 |doi= 10.1073/pnas.241522398
*cite journal | author=Iida A, Saito S, Sekine A, "et al." |title=Thirteen single-nucleotide polymorphisms (SNPs) in the alcohol dehydrogenase 4 (ADH4) gene locus. |journal=J. Hum. Genet. |volume=47 |issue= 2 |pages= 74–6 |year= 2002 |pmid= 11916005 |doi=
*cite journal | author=Strömberg P, Svensson S, Hedberg JJ, "et al." |title=Identification and characterisation of two allelic forms of human alcohol dehydrogenase 2. |journal=Cell. Mol. Life Sci. |volume=59 |issue= 3 |pages= 552–9 |year= 2002 |pmid= 11964133 |doi=
*cite journal | author=Chou CF, Lai CL, Chang YC, "et al." |title=Kinetic mechanism of human class IV alcohol dehydrogenase functioning as retinol dehydrogenase. |journal=J. Biol. Chem. |volume=277 |issue= 28 |pages= 25209–16 |year= 2002 |pmid= 11997393 |doi= 10.1074/jbc.M201947200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Galter D, Carmine A, Buervenich S, "et al." |title=Distribution of class I, III and IV alcohol dehydrogenase mRNAs in the adult rat, mouse and human brain. |journal=Eur. J. Biochem. |volume=270 |issue= 6 |pages= 1316–26 |year= 2003 |pmid= 12631290 |doi=
*cite journal | author=Neumark YD, Friedlander Y, Durst R, "et al." |title=Alcohol dehydrogenase polymorphisms influence alcohol-elimination rates in a male Jewish population. |journal=Alcohol. Clin. Exp. Res. |volume=28 |issue= 1 |pages= 10–4 |year= 2004 |pmid= 14745297 |doi= 10.1097/01.ALC.0000108667.79219.4D
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Luo X, Kranzler HR, Zuo L, "et al." |title=ADH4 gene variation is associated with alcohol and drug dependence: results from family controlled and population-structured association studies. |journal=Pharmacogenet. Genomics |volume=15 |issue= 11 |pages= 755–68 |year= 2006 |pmid= 16220108 |doi=
*cite journal | author=Luo X, Kranzler HR, Zuo L, "et al." |title=ADH4 gene variation is associated with alcohol dependence and drug dependence in European Americans: results from HWD tests and case-control association studies. |journal=Neuropsychopharmacology |volume=31 |issue= 5 |pages= 1085–95 |year= 2006 |pmid= 16237392 |doi= 10.1038/sj.npp.1300925
*cite journal | author=Luo X, Kranzler HR, Zuo L, "et al." |title=Personality traits of agreeableness and extraversion are associated with ADH4 variation. |journal=Biol. Psychiatry |volume=61 |issue= 5 |pages= 599–608 |year= 2007 |pmid= 17069770 |doi= 10.1016/j.biopsych.2006.05.017

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