CCNT2

Cyclin T2, also known as CCNT2, is a human gene.cite web | title = Entrez Gene: CCNT2 cyclin T2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=905| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin and its kinase partner CDK9 were found to be subunits of the transcription elongation factor p-TEFb. The p-TEFb complex containing this cyclin was reported to interact with, and act as a negative regulator of human immunodeficiency virus type 1 (HIV-1) Tat protein. Two alternatively spliced transcript variants, which encode distinct isoforms, have been described.cite web | title = Entrez Gene: CCNT2 cyclin T2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=905| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Wolff A |title= [Problem of occupational disability hazards] |journal=Lebensversicherungs Medizin |volume=28 |issue= 3 |pages= 76–7 |year= 1976 |pmid= 9544 |doi=
*cite journal | author=Peng J, Zhu Y, Milton JT, Price DH |title=Identification of multiple cyclin subunits of human P-TEFb. |journal=Genes Dev. |volume=12 |issue= 5 |pages= 755–62 |year= 1998 |pmid= 9499409 |doi=
*cite journal | author=Wimmer J, Fujinaga K, Taube R, "et al." |title=Interactions between Tat and TAR and human immunodeficiency virus replication are facilitated by human cyclin T1 but not cyclins T2a or T2b. |journal=Virology |volume=255 |issue= 1 |pages= 182–9 |year= 1999 |pmid= 10049833 |doi= 10.1006/viro.1998.9589
*cite journal | author=Kwak YT, Ivanov D, Guo J, "et al." |title=Role of the human and murine cyclin T proteins in regulating HIV-1 tat-activation. |journal=J. Mol. Biol. |volume=288 |issue= 1 |pages= 57–69 |year= 1999 |pmid= 10329126 |doi= 10.1006/jmbi.1999.2664
*cite journal | author=Bieniasz PD, Grdina TA, Bogerd HP, Cullen BR |title=Analysis of the effect of natural sequence variation in Tat and in cyclin T on the formation and RNA binding properties of Tat-cyclin T complexes. |journal=J. Virol. |volume=73 |issue= 7 |pages= 5777–86 |year= 1999 |pmid= 10364329 |doi=
*cite journal | author=Napolitano G, Licciardo P, Gallo P, "et al." |title=The CDK9-associated cyclins T1 and T2 exert opposite effects on HIV-1 Tat activity. |journal=AIDS |volume=13 |issue= 12 |pages= 1453–9 |year= 1999 |pmid= 10465067 |doi=
*cite journal | author=Herrmann CH, Mancini MA |title=The Cdk9 and cyclin T subunits of TAK/P-TEFb localize to splicing factor-rich nuclear speckle regions. |journal=J. Cell. Sci. |volume=114 |issue= Pt 8 |pages= 1491–503 |year= 2001 |pmid= 11282025 |doi=
*cite journal | author=Nguyen VT, Kiss T, Michels AA, Bensaude O |title=7SK small nuclear RNA binds to and inhibits the activity of CDK9/cyclin T complexes. |journal=Nature |volume=414 |issue= 6861 |pages= 322–5 |year= 2001 |pmid= 11713533 |doi= 10.1038/35104581
*cite journal | author=Tolstonog GV, Mothes E, Shoeman RL, Traub P |title=Isolation of SDS-stable complexes of the intermediate filament protein vimentin with repetitive, mobile, nuclear matrix attachment region, and mitochondrial DNA sequence elements from cultured mouse and human fibroblasts. |journal=DNA Cell Biol. |volume=20 |issue= 9 |pages= 531–54 |year= 2002 |pmid= 11747605 |doi= 10.1089/104454901317094954
*cite journal | author=Simone C, Bagella L, Bellan C, Giordano A |title=Physical interaction between pRb and cdk9/cyclinT2 complex. |journal=Oncogene |volume=21 |issue= 26 |pages= 4158–65 |year= 2002 |pmid= 12037672 |doi= 10.1038/sj.onc.1205511
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Michels AA, Nguyen VT, Fraldi A, "et al." |title=MAQ1 and 7SK RNA interact with CDK9/cyclin T complexes in a transcription-dependent manner. |journal=Mol. Cell. Biol. |volume=23 |issue= 14 |pages= 4859–69 |year= 2003 |pmid= 12832472 |doi=
*cite journal | author=Beausoleil SA, Jedrychowski M, Schwartz D, "et al." |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130–5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101
*cite journal | author=Kurosu T, Zhang F, Peterlin BM |title=Transcriptional activity and substrate recognition of cyclin T2 from P-TEFb. |journal=Gene |volume=343 |issue= 1 |pages= 173–9 |year= 2005 |pmid= 15563843 |doi= 10.1016/j.gene.2004.08.027
*cite journal | author=Hillier LW, Graves TA, Fulton RS, "et al." |title=Generation and annotation of the DNA sequences of human chromosomes 2 and 4. |journal=Nature |volume=434 |issue= 7034 |pages= 724–31 |year= 2005 |pmid= 15815621 |doi= 10.1038/nature03466
*cite journal | author=Jang MK, Mochizuki K, Zhou M, "et al." |title=The bromodomain protein Brd4 is a positive regulatory component of P-TEFb and stimulates RNA polymerase II-dependent transcription. |journal=Mol. Cell |volume=19 |issue= 4 |pages= 523–34 |year= 2005 |pmid= 16109376 |doi= 10.1016/j.molcel.2005.06.027
*cite journal | author=Cottone G, Baldi A, Palescandolo E, "et al." |title=Pkn is a novel partner of cyclin T2a in muscle differentiation. |journal=J. Cell. Physiol. |volume=207 |issue= 1 |pages= 232–7 |year= 2006 |pmid= 16331689 |doi= 10.1002/jcp.20566
*cite journal | author=Simone C, Giordano A |title=Abrogation of signal-dependent activation of the cdk9/cyclin T2a complex in human RD rhabdomyosarcoma cells. |journal=Cell Death Differ. |volume=14 |issue= 1 |pages= 192–5 |year= 2007 |pmid= 16841087 |doi= 10.1038/sj.cdd.4402008
*cite journal | author=Fu J, Yoon HG, Qin J, Wong J |title=Regulation of P-TEFb elongation complex activity by CDK9 acetylation. |journal=Mol. Cell. Biol. |volume=27 |issue= 13 |pages= 4641–51 |year= 2007 |pmid= 17452463 |doi= 10.1128/MCB.00857-06

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